BACKGROUND: There have been several studies on diet and gastric cancer, but only a few investigations have considered the role of dietary patterns. METHODS: We investigated gastric cancer risk in relation to dietary patterns in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals as cases, with acute nonneoplastic conditions. Dietary habits were investigated through a validated food frequency questionnaire including 78 foods and beverages. We identified a posteriori dietary patterns on a selected set of 28 micro- and macro-nutrients through an exploratory principal component factor analysis. We estimated the odds ratios (OR) and the corresponding 95% confidence intervals (95% CI) using conditional logistic regression models on quartiles of factor scores. RESULTS: We identified four major dietary patterns, named "animal products", "vitamins and fiber", "vegetable unsaturated fatty acids", and "starch-rich". We observed a positive association between gastric cancer risk and the "animal products" (OR, 2.13; 95% CI, 1.34-3.40, for the highest versus the lowest score quartile) and the "starch-rich" (OR, 1.67; 95% CI, 1.01-2.77) dietary patterns. The "vitamins and fiber" pattern (OR, 0.60; 95% CI, 0.37-0.99) was inversely associated with gastric cancer, whereas no significant association emerged with the "vegetable unsaturated fatty acids" pattern (OR, 0.89; 95% CI, 0.56-1.42). CONCLUSIONS: Our analysis suggests a protective effect against gastric cancer risk of dietary patterns rich in fruits and vegetables, and a positive association of dietary patterns rich in meats and animal fats and starchy foods.
BACKGROUND: There have been several studies on diet and gastric cancer, but only a few investigations have considered the role of dietary patterns. METHODS: We investigated gastric cancer risk in relation to dietary patterns in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals as cases, with acute nonneoplastic conditions. Dietary habits were investigated through a validated food frequency questionnaire including 78 foods and beverages. We identified a posteriori dietary patterns on a selected set of 28 micro- and macro-nutrients through an exploratory principal component factor analysis. We estimated the odds ratios (OR) and the corresponding 95% confidence intervals (95% CI) using conditional logistic regression models on quartiles of factor scores. RESULTS: We identified four major dietary patterns, named "animal products", "vitamins and fiber", "vegetable unsaturated fatty acids", and "starch-rich". We observed a positive association between gastric cancer risk and the "animal products" (OR, 2.13; 95% CI, 1.34-3.40, for the highest versus the lowest score quartile) and the "starch-rich" (OR, 1.67; 95% CI, 1.01-2.77) dietary patterns. The "vitamins and fiber" pattern (OR, 0.60; 95% CI, 0.37-0.99) was inversely associated with gastric cancer, whereas no significant association emerged with the "vegetable unsaturated fatty acids" pattern (OR, 0.89; 95% CI, 0.56-1.42). CONCLUSIONS: Our analysis suggests a protective effect against gastric cancer risk of dietary patterns rich in fruits and vegetables, and a positive association of dietary patterns rich in meats and animal fats and starchy foods.
Authors: Shailja C Shah; Qi Dai; Xiangzhu Zhu; Richard M Peek; Walter Smalley; Christianne Roumie; Martha J Shrubsole Journal: Int J Cancer Date: 2019-10-12 Impact factor: 7.396
Authors: Stephanie C Melkonian; Carrie R Daniel; Michelle A T Hildebrandt; Nizar M Tannir; Yuanqing Ye; Wong-Ho Chow; Christopher G Wood; Xifeng Wu Journal: Am J Epidemiol Date: 2014-07-22 Impact factor: 4.897
Authors: Pedro T Pisa; Titilola M Pedro; Kathleen Kahn; Stephen M Tollman; John M Pettifor; Shane A Norris Journal: Nutrients Date: 2015-05-12 Impact factor: 5.717
Authors: Aurelie Moskal; Pedro T Pisa; Pietro Ferrari; Graham Byrnes; Heinz Freisling; Marie-Christine Boutron-Ruault; Claire Cadeau; Laura Nailler; Andrea Wendt; Tilman Kühn; Heiner Boeing; Brian Buijsse; Anne Tjønneland; Jytte Halkjær; Christina C Dahm; Stephanie E Chiuve; Jose R Quirós; Genevieve Buckland; Esther Molina-Montes; Pilar Amiano; José M Huerta Castaño; Aurelio Barricarte Gurrea; Kay-Tee Khaw; Marleen A Lentjes; Timothy J Key; Dora Romaguera; Anne-Claire Vergnaud; Antonia Trichopoulou; Christina Bamia; Philippos Orfanos; Domenico Palli; Valeria Pala; Rosario Tumino; Carlotta Sacerdote; Maria Santucci de Magistris; H Bas Bueno-de-Mesquita; Marga C Ocké; Joline W J Beulens; Ulrika Ericson; Isabel Drake; Lena M Nilsson; Anna Winkvist; Elisabete Weiderpass; Anette Hjartåker; Elio Riboli; Nadia Slimani Journal: PLoS One Date: 2014-06-05 Impact factor: 3.240