Literature DB >> 19857162

T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors.

Ahmad R Sedaghat1, Darius A Rastegar, Karen A O'Connell, Jason B Dinoso, Claus O Wilke, Joel N Blankson.   

Abstract

Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.

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Year:  2009        PMID： 19857162      PMCID： PMC2783537          DOI： 10.1086/648081

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  14 in total

Review 1.  Simultaneous inference in general parametric models.

Authors:  Torsten Hothorn; Frank Bretz; Peter Westfall
Journal:  Biom J       Date:  2008-06       Impact factor: 2.207

2.  Declining CD4 T-cell counts in a person infected with nef-deleted HIV-1.

Authors:  T C Greenough; J L Sullivan; R C Desrosiers
Journal:  N Engl J Med       Date:  1999-01-21       Impact factor: 91.245

3.  Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.

Authors:  Joel N Blankson; Justin R Bailey; Seema Thayil; Hung-Chih Yang; Kara Lassen; Jun Lai; Shiv K Gandhi; Janet D Siliciano; Thomas M Williams; Robert F Siliciano
Journal:  J Virol       Date:  2006-12-06       Impact factor: 5.103

4.  Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.

Authors:  J V Giorgi; L E Hultin; J A McKeating; T D Johnson; B Owens; L P Jacobson; R Shih; J Lewis; D J Wiley; J P Phair; S M Wolinsky; R Detels
Journal:  J Infect Dis       Date:  1999-04       Impact factor: 5.226

5.  Chronic CD4+ T-cell activation and depletion in human immunodeficiency virus type 1 infection: type I interferon-mediated disruption of T-cell dynamics.

Authors:  Ahmad R Sedaghat; Jennifer German; Tanya M Teslovich; Joseph Cofrancesco; Chunfa C Jie; C Conover Talbot; Robert F Siliciano
Journal:  J Virol       Date:  2007-12-12       Impact factor: 5.103

6.  CD4+ T cell depletion in an untreated HIV type 1-infected human leukocyte antigen-B*5801-positive patient with an undetectable viral load.

Authors:  Adriana Andrade; Justin R Bailey; Jie Xu; Frances H Philp; Thomas C Quinn; Thomas M Williams; Stuart C Ray; David L Thomas; Joel N Blankson
Journal:  Clin Infect Dis       Date:  2008-04-15       Impact factor: 9.079

7.  Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy.

Authors:  Peter W Hunt; Jason Brenchley; Elizabeth Sinclair; Joseph M McCune; Michelle Roland; Kimberly Page-Shafer; Priscilla Hsue; Brinda Emu; Melissa Krone; Harry Lampiris; Daniel Douek; Jeffrey N Martin; Steven G Deeks
Journal:  J Infect Dis       Date:  2008-01-01       Impact factor: 5.226

8.  A comparison of viral loads between HIV-1-infected elite suppressors and individuals who receive suppressive highly active antiretroviral therapy.

Authors:  Jason B Dinoso; Scott Y Kim; Robert F Siliciano; Joel N Blankson
Journal:  Clin Infect Dis       Date:  2008-07-01       Impact factor: 9.079

9.  Spontaneous control of viral load and CD4 cell count progression among HIV-1 seroconverters.

Authors:  Yoann Madec; Faroudy Boufassa; Kholoud Porter; Laurence Meyer
Journal:  AIDS       Date:  2005-11-18       Impact factor: 4.177

10.  Transient nature of long-term nonprogression and broad virus-specific proliferative T-cell responses with sustained thymic output in HIV-1 controllers.

Authors:  Samantha J Westrop; Nadeem A Qazi; Jeffrey Pido-Lopez; Mark R Nelson; Brian Gazzard; Frances M Gotch; Nesrina Imami
Journal:  PLoS One       Date:  2009-05-12       Impact factor: 3.240
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  29 in total

1.  CD4 T-cell regeneration in HIV-1 elite controllers.

Authors:  Yue Yang; Maha Al-Mozaini; Maria J Buzon; Jill Beamon; Sara Ferrando-Martinez; Ezequiel Ruiz-Mateos; Eric S Rosenberg; Florencia Pereyra; Xu G Yu; Mathias Lichterfeld
Journal:  AIDS       Date:  2012-03-27       Impact factor: 4.177

2.  HIV controllers with different viral load cutoff levels have distinct virologic and immunologic profiles.

Authors:  Fernanda H Côrtes; Caroline Pb Passaes; Gonzalo Bello; Sylvia Lm Teixeira; Carla Vorsatz; Dunja Babic; Mark Sharkey; Beatriz Grinsztejn; Valdilea Veloso; Mario Stevenson; Mariza G Morgado
Journal:  J Acquir Immune Defic Syndr       Date:  2015-04-01       Impact factor: 3.731

3.  T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers.

Authors:  Philomena Kamya; Christos M Tsoukas; Salix Boulet; Jean-Pierre Routy; Réjean Thomas; Pierre Côté; Mohamed-Rachid Boulassel; Bernard Lessard; Rupert Kaul; Mario Ostrowski; Colin Kovacs; Cecile L Tremblay; Nicole F Bernard
Journal:  AIDS Res Ther       Date:  2011-06-16       Impact factor: 2.250

4.  Long-term control of viral replication in a Group O, human immunodeficiency virus type 1-infected individual.

Authors:  Robert W Buckheit; Stephen B Sexauer; Ahmad R Sedaghat; Claus O Wilke; Oliver Laeyendecker; Christie R Basseth; Joel N Blankson
Journal:  AIDS Res Hum Retroviruses       Date:  2014-06       Impact factor: 2.205

Review 5.  HIV controllers: a multifactorial phenotype of spontaneous viral suppression.

Authors:  Jacques Thèze; Lisa A Chakrabarti; Benoît Vingert; Filippos Porichis; Daniel E Kaufmann
Journal:  Clin Immunol       Date:  2011-08-04       Impact factor: 3.969

6.  Chronic immune activation and decreased CD4 cell counts associated with hepatitis C infection in HIV-1 natural viral suppressors.

Authors:  Mohammad M Sajadi; Roopa Pulijala; Robert R Redfield; Rohit Talwani
Journal:  AIDS       Date:  2012-09-24       Impact factor: 4.177

7.  Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers.

Authors:  Francois Vigneault; Matthew Woods; Maria J Buzon; Chun Li; Florencia Pereyra; Seth D Crosby; Jennifer Rychert; George Church; Javier Martinez-Picado; Eric S Rosenberg; Amalio Telenti; Xu G Yu; Mathias Lichterfeld
Journal:  J Virol       Date:  2010-12-22       Impact factor: 5.103

Review 8.  The implications of viral reservoirs on the elite control of HIV-1 infection.

Authors:  Robert W Buckheit; Maria Salgado; Karen O Martins; Joel N Blankson
Journal:  Cell Mol Life Sci       Date:  2012-08-04       Impact factor: 9.261

9.  Normal T-cell activation in elite controllers with preserved CD4+ T-cell counts.

Authors:  Anju Bansal; Sarah Sterrett; Nathan Erdmann; Andrew O Westfall; Jodie Dionne-Odom; Edgar T Overton; Paul A Goepfert
Journal:  AIDS       Date:  2015-11       Impact factor: 4.177

10.  Effect of antiretroviral therapy on HIV reservoirs in elite controllers.

Authors:  Tae-Wook Chun; J Shawn Justement; Danielle Murray; Connie J Kim; Jana Blazkova; Claire W Hallahan; Erika Benko; Cecilia T Costiniuk; Gabor Kandel; Mario Ostrowski; Rupert Kaul; Susan Moir; Joseph P Casazza; Richard A Koup; Colin Kovacs; Anthony S Fauci
Journal:  J Infect Dis       Date:  2013-07-11       Impact factor: 5.226
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