Literature DB >> 18444844

CD4+ T cell depletion in an untreated HIV type 1-infected human leukocyte antigen-B*5801-positive patient with an undetectable viral load.

Adriana Andrade1, Justin R Bailey, Jie Xu, Frances H Philp, Thomas C Quinn, Thomas M Williams, Stuart C Ray, David L Thomas, Joel N Blankson.   

Abstract

We report a case of a patient infected with human immunodeficiency virus type 1 (HIV-1) for 20 years who has experienced CD4(+) T cell depletion in spite of maintaining undetectable viral loads. Our data suggest that immune activation can cause CD4(+) T cell depletion even when HIV-1 replication appears to be controlled by host factors.

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Year:  2008        PMID： 18444844      PMCID： PMC2664682          DOI： 10.1086/529387

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  15 in total

1.  Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease.

Authors:  Shailesh K Choudhary; Nienke Vrisekoop; Christine A Jansen; Sigrid A Otto; Hanneke Schuitemaker; Frank Miedema; David Camerini
Journal:  J Virol       Date:  2007-05-30       Impact factor: 5.103

2.  Declining CD4 T-cell counts in a person infected with nef-deleted HIV-1.

Authors:  T C Greenough; J L Sullivan; R C Desrosiers
Journal:  N Engl J Med       Date:  1999-01-21       Impact factor: 91.245

3.  Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapy.

Authors:  J P Casazza; M R Betts; L J Picker; R A Koup
Journal:  J Virol       Date:  2001-07       Impact factor: 5.103

4.  Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort.

Authors:  J C Learmont; A F Geczy; J Mills; L J Ashton; C H Raynes-Greenow; R J Garsia; W B Dyer; L McIntyre; R B Oelrichs; D I Rhodes; N J Deacon; J S Sullivan
Journal:  N Engl J Med       Date:  1999-06-03       Impact factor: 91.245

5.  HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors.

Authors:  S A Migueles; M S Sabbaghian; W L Shupert; M P Bettinotti; F M Marincola; L Martino; C W Hallahan; S M Selig; D Schwartz; J Sullivan; M Connors
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

6.  Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.

Authors:  J V Giorgi; L E Hultin; J A McKeating; T D Johnson; B Owens; L P Jacobson; R Shih; J Lewis; D J Wiley; J P Phair; S M Wolinsky; R Detels
Journal:  J Infect Dis       Date:  1999-04       Impact factor: 5.226

7.  Idiopathic CD4+ T-lymphocytopenia--immunodeficiency without evidence of HIV infection.

Authors:  D D Ho; Y Cao; T Zhu; C Farthing; N Wang; G Gu; R T Schooley; E S Daar
Journal:  N Engl J Med       Date:  1993-02-11       Impact factor: 91.245

8.  CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load.

Authors:  Ana E Sousa; Jorge Carneiro; Martin Meier-Schellersheim; Zvi Grossman; Rui M M Victorino
Journal:  J Immunol       Date:  2002-09-15       Impact factor: 5.422

9.  Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.

Authors:  M M Addo; X G Yu; A Rathod; D Cohen; R L Eldridge; D Strick; M N Johnston; C Corcoran; A G Wurcel; C A Fitzpatrick; M E Feeney; W R Rodriguez; N Basgoz; R Draenert; David R Stone; C Brander; P J R Goulder; E S Rosenberg; M Altfeld; B D Walker
Journal:  J Virol       Date:  2003-02       Impact factor: 5.103

10.  Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion.

Authors:  J W Mellors; L A Kingsley; C R Rinaldo; J A Todd; B S Hoo; R P Kokka; P Gupta
Journal:  Ann Intern Med       Date:  1995-04-15       Impact factor: 25.391
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  18 in total

1.  Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus.

Authors:  Karen A O'Connell; Timothy P Brennan; Justin R Bailey; Stuart C Ray; Robert F Siliciano; Joel N Blankson
Journal:  J Virol       Date:  2010-05-05       Impact factor: 5.103

2.  Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters.

Authors:  Florencia Pereyra; Sarah Palmer; Toshiyuki Miura; Brian L Block; Ann Wiegand; Alissa C Rothchild; Brett Baker; Rachel Rosenberg; Emily Cutrell; Michael S Seaman; John M Coffin; Bruce D Walker
Journal:  J Infect Dis       Date:  2009-09-15       Impact factor: 5.226

3.  HIV controllers with different viral load cutoff levels have distinct virologic and immunologic profiles.

Authors:  Fernanda H Côrtes; Caroline Pb Passaes; Gonzalo Bello; Sylvia Lm Teixeira; Carla Vorsatz; Dunja Babic; Mark Sharkey; Beatriz Grinsztejn; Valdilea Veloso; Mario Stevenson; Mariza G Morgado
Journal:  J Acquir Immune Defic Syndr       Date:  2015-04-01       Impact factor: 3.731

4.  T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers.

Authors:  Philomena Kamya; Christos M Tsoukas; Salix Boulet; Jean-Pierre Routy; Réjean Thomas; Pierre Côté; Mohamed-Rachid Boulassel; Bernard Lessard; Rupert Kaul; Mario Ostrowski; Colin Kovacs; Cecile L Tremblay; Nicole F Bernard
Journal:  AIDS Res Ther       Date:  2011-06-16       Impact factor: 2.250

5.  Evidence of dysregulation of dendritic cells in primary HIV infection.

Authors:  Rachel Lubong Sabado; Meagan O'Brien; Abhignya Subedi; Li Qin; Nan Hu; Elizabeth Taylor; Oliver Dibben; Andrea Stacey; Jacques Fellay; Kevin V Shianna; Frederick Siegal; Michael Shodell; Kokila Shah; Marie Larsson; Jeffrey Lifson; Arthur Nadas; Michael Marmor; Richard Hutt; David Margolis; Donald Garmon; Martin Markowitz; Fred Valentine; Persephone Borrow; Nina Bhardwaj
Journal:  Blood       Date:  2010-08-06       Impact factor: 22.113

6.  Epidemiologic characteristics and natural history of HIV-1 natural viral suppressors.

Authors:  Mohammad M Sajadi; Neil T Constantine; Dean L Mann; Manhattan Charurat; Elham Dadzan; Peter Kadlecik; Robert R Redfield
Journal:  J Acquir Immune Defic Syndr       Date:  2009-04-01       Impact factor: 3.731

7.  Quantifying T lymphocyte turnover.

Authors:  Rob J De Boer; Alan S Perelson
Journal:  J Theor Biol       Date:  2013-01-09       Impact factor: 2.691

8.  T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors.

Authors:  Ahmad R Sedaghat; Darius A Rastegar; Karen A O'Connell; Jason B Dinoso; Claus O Wilke; Joel N Blankson
Journal:  Clin Infect Dis       Date:  2009-12-01       Impact factor: 9.079

Review 9.  Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses?

Authors:  Joel N Blankson
Journal:  Antiviral Res       Date:  2009-09-04       Impact factor: 5.970

Review 10.  The implications of viral reservoirs on the elite control of HIV-1 infection.

Authors:  Robert W Buckheit; Maria Salgado; Karen O Martins; Joel N Blankson
Journal:  Cell Mol Life Sci       Date:  2012-08-04       Impact factor: 9.261
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