Literature DB >> 18494606

A comparison of viral loads between HIV-1-infected elite suppressors and individuals who receive suppressive highly active antiretroviral therapy.

Jason B Dinoso1, Scott Y Kim, Robert F Siliciano, Joel N Blankson.   

Abstract

Elite suppressors are untreated individuals with human immunodeficiency virus type 1 (HIV-1) infection who maintain viral loads <50 copies/mL. Using a single-copy assay, we show that there is no statistically significant difference between the proportions of elite suppressors and patients receiving suppressive highly active antiretroviral therapy who have viral loads of <1 copy/mL.

Entities:  

Mesh：

Year:  2008        PMID： 18494606      PMCID： PMC2564994          DOI： 10.1086/588791

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  11 in total

1.  HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors.

Authors:  Stephen A Migueles; Alisha C Laborico; W Lesley Shupert; M Shirin Sabbaghian; Ronald Rabin; Claire W Hallahan; Debbie Van Baarle; Stefan Kostense; Frank Miedema; Mary McLaughlin; Linda Ehler; Julia Metcalf; Shuying Liu; Mark Connors
Journal:  Nat Immunol       Date:  2002-10-07       Impact factor: 25.606

2.  Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy.

Authors:  Justin R Bailey; Kara G Lassen; Hung-Chih Yang; Thomas C Quinn; Stuart C Ray; Joel N Blankson; Robert F Siliciano
Journal:  J Virol       Date:  2006-05       Impact factor: 5.103

3.  Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells.

Authors:  Justin R Bailey; Ahmad R Sedaghat; Tara Kieffer; Timothy Brennan; Patricia K Lee; Megan Wind-Rotolo; Christine M Haggerty; Ashrit R Kamireddi; Yi Liu; Jessica Lee; Deborah Persaud; Joel E Gallant; Joseph Cofrancesco; Thomas C Quinn; Claus O Wilke; Stuart C Ray; Janet D Siliciano; Richard E Nettles; Robert F Siliciano
Journal:  J Virol       Date:  2006-07       Impact factor: 5.103

4.  Decay characteristics of HIV-1-infected compartments during combination therapy.

Authors:  A S Perelson; P Essunger; Y Cao; M Vesanen; A Hurley; K Saksela; M Markowitz; D D Ho
Journal:  Nature       Date:  1997-05-08       Impact factor: 49.962

5.  Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.

Authors:  Joel N Blankson; Justin R Bailey; Seema Thayil; Hung-Chih Yang; Kara Lassen; Jun Lai; Shiv K Gandhi; Janet D Siliciano; Thomas M Williams; Robert F Siliciano
Journal:  J Virol       Date:  2006-12-06       Impact factor: 5.103

6.  HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors.

Authors:  S A Migueles; M S Sabbaghian; W L Shupert; M P Bettinotti; F M Marincola; L Martino; C W Hallahan; S M Selig; D Schwartz; J Sullivan; M Connors
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

7.  Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.

Authors:  Daniel E Kaufmann; Daniel G Kavanagh; Florencia Pereyra; John J Zaunders; Elizabeth W Mackey; Toshiyuki Miura; Sarah Palmer; Mark Brockman; Almas Rathod; Alicja Piechocka-Trocha; Brett Baker; Baogong Zhu; Sylvie Le Gall; Michael T Waring; Ryan Ahern; Kristin Moss; Anthony D Kelleher; John M Coffin; Gordon J Freeman; Eric S Rosenberg; Bruce D Walker
Journal:  Nat Immunol       Date:  2007-09-30       Impact factor: 25.606

8.  New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma.

Authors:  Sarah Palmer; Ann P Wiegand; Frank Maldarelli; Holly Bazmi; JoAnn M Mican; Michael Polis; Robin L Dewar; Angeline Planta; Shuying Liu; Julia A Metcalf; John W Mellors; John M Coffin
Journal:  J Clin Microbiol       Date:  2003-10       Impact factor: 5.948

9.  Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations.

Authors:  Justin R Bailey; Thomas M Williams; Robert F Siliciano; Joel N Blankson
Journal:  J Exp Med       Date:  2006-05-08       Impact factor: 14.307

10.  ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia.

Authors:  Frank Maldarelli; Sarah Palmer; Martin S King; Ann Wiegand; Michael A Polis; JoAnn Mican; Joseph A Kovacs; Richard T Davey; Diane Rock-Kress; Robin Dewar; Shuying Liu; Julia A Metcalf; Catherine Rehm; Scott C Brun; George J Hanna; Dale J Kempf; John M Coffin; John W Mellors
Journal:  PLoS Pathog       Date:  2007-04       Impact factor: 6.823
View more
  35 in total

1.  HIV-1 continues to replicate and evolve in patients with natural control of HIV infection.

Authors:  Helene Mens; Mary Kearney; Ann Wiegand; Wei Shao; Kristian Schønning; Jan Gerstoft; Niels Obel; Frank Maldarelli; John W Mellors; Thomas Benfield; John M Coffin
Journal:  J Virol       Date:  2010-10-06       Impact factor: 5.103

2.  Comprehensive analysis of unique cases with extraordinary control over HIV replication.

Authors:  Daniel Mendoza; Sarah A Johnson; Bennett A Peterson; Ven Natarajan; Maria Salgado; Robin L Dewar; Peter D Burbelo; Nicole A Doria-Rose; Erin H Graf; Jamieson H Greenwald; Jessica N Hodge; William L Thompson; Nancy A Cogliano; Cheryl L Chairez; Catherine A Rehm; Sara Jones; Claire W Hallahan; Joseph A Kovacs; Irini Sereti; Omar Sued; Sheila A Peel; Robert J O'Connell; Una O'Doherty; Tae-Wook Chun; Mark Connors; Stephen A Migueles
Journal:  Blood       Date:  2012-04-05       Impact factor: 22.113

3.  Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus.

Authors:  Karen A O'Connell; Timothy P Brennan; Justin R Bailey; Stuart C Ray; Robert F Siliciano; Joel N Blankson
Journal:  J Virol       Date:  2010-05-05       Impact factor: 5.103

4.  HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice.

Authors:  Maria Salgado; Michael D Swanson; Christopher W Pohlmeyer; Robert W Buckheit; Jin Wu; Nancie M Archin; Thomas M Williams; David M Margolis; Robert F Siliciano; J Victor Garcia; Joel N Blankson
Journal:  J Virol       Date:  2014-01-03       Impact factor: 5.103

5.  Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters.

Authors:  Florencia Pereyra; Sarah Palmer; Toshiyuki Miura; Brian L Block; Ann Wiegand; Alissa C Rothchild; Brett Baker; Rachel Rosenberg; Emily Cutrell; Michael S Seaman; John M Coffin; Bruce D Walker
Journal:  J Infect Dis       Date:  2009-09-15       Impact factor: 5.226

6.  In vivo HIV-1 hypermutation and viral loads among antiretroviral-naive Brazilian patients.

Authors:  Mariana Leão de Lima-Stein; Wagner Tadeu Alkmim; Maria Clara de Souza Bizinoto; Luis Fernandez Lopez; Marcelo Nascimento Burattini; Juliana Terzi Maricato; Leila Giron; Maria Cecília Araripe Sucupira; Ricardo Sobhie Diaz; Luiz Mario Janini
Journal:  AIDS Res Hum Retroviruses       Date:  2014-08-25       Impact factor: 2.205

7.  Demographics and natural history of HIV-1-infected spontaneous controllers of viremia.

Authors:  Otto O Yang; William G Cumberland; Robert Escobar; Diana Liao; Kara W Chew
Journal:  AIDS       Date:  2017-05-15       Impact factor: 4.177

8.  T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers.

Authors:  Philomena Kamya; Christos M Tsoukas; Salix Boulet; Jean-Pierre Routy; Réjean Thomas; Pierre Côté; Mohamed-Rachid Boulassel; Bernard Lessard; Rupert Kaul; Mario Ostrowski; Colin Kovacs; Cecile L Tremblay; Nicole F Bernard
Journal:  AIDS Res Ther       Date:  2011-06-16       Impact factor: 2.250

Review 9.  New tools for quantifying HIV-1 reservoirs: plasma RNA single copy assays and beyond.

Authors:  Benedict B Hilldorfer; Anthony R Cillo; Guillaume J Besson; Margaret Anne Bedison; John W Mellors
Journal:  Curr HIV/AIDS Rep       Date:  2012-03       Impact factor: 5.071

10.  HIV RNA levels in plasma and cervical-vaginal lavage fluid in elite controllers and HAART recipients.

Authors:  Alan Landay; Elizabeth T Golub; Seema Desai; Jinbing Zhang; Val Winkelman; Kathryn Anastos; Helen Durkin; Mary Young; Maria C Villacres; Ruth M Greenblatt; Philip J Norris; Michael P Busch
Journal:  AIDS       Date:  2014-03-13       Impact factor: 4.177
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.