Literature DB >> 19853459

Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity.

Anastasia Detsi1, Maya Majdalani, Christos A Kontogiorgis, Dimitra Hadjipavlou-Litina, Panagiotis Kefalas.   

Abstract

A series of 2'-hydroxy-chalcones and their oxidative cyclization products, aurones, have been synthesized and tested for their antioxidant and lipoxygenase inhibitory activity. The natural product aureusidin (31) was synthesized in high yield by a new approach. An extensive structure-relationship study was performed and revealed that several chalcones and aurones possess an appealing pharmacological profile combining high antioxidant and lipid peroxidation activity with potent soybean LOX inhibition.

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Year:  2009        PMID： 19853459     DOI： 10.1016/j.bmc.2009.10.002

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  20 in total

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Authors:  Khushboo D Malbari; Anand S Chintakrindi; Lata R Ganji; Devanshi J Gohil; Sweta T Kothari; Mamata V Joshi; Meena A Kanyalkar
Journal:  Mol Divers       Date:  2019-02-01       Impact factor: 2.943

2.  15-Lipoxygenase inhibition of Commelina benghalensis, Tradescantia fluminensis, Tradescantia zebrina.

Authors:  Cean Socorro M Alaba; Christine L Chichioco-Hernandez
Journal:  Asian Pac J Trop Biomed       Date:  2014-03

3.  Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers.

Authors:  Tze Han Sum; Tze Jing Sum; Warren R J D Galloway; Súil Collins; David G Twigg; Florian Hollfelder; David R Spring
Journal:  Molecules       Date:  2016-09-16       Impact factor: 4.411

4.  Cardioprotective activity of chalcones in ischemia/reperfusion-induced myocardial infarction in albino rats.

Authors:  Akula Annapurna; Manjunatha P Mudagal; Asif Ansari; Srinivasa Rao A
Journal:  Exp Clin Cardiol       Date:  2012-09

5.  Novel quinolinone-pyrazoline hybrids: synthesis and evaluation of antioxidant and lipoxygenase inhibitory activity.

Authors:  Ioanna Kostopoulou; Antonia Diassakou; Eleni Kavetsou; Eftichia Kritsi; Panagiotis Zoumpoulakis; Eleni Pontiki; Dimitra Hadjipavlou-Litina; Anastasia Detsi
Journal:  Mol Divers       Date:  2020-02-17       Impact factor: 2.943

6.  Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers.

Authors:  Emily Hofmann; Jonathan Webster; Thuy Do; Reid Kline; Lindsey Snider; Quintin Hauser; Grace Higginbottom; Austin Campbell; Lili Ma; Stefan Paula
Journal:  Bioorg Med Chem       Date:  2015-12-17       Impact factor: 3.641

7.  (E)-3-(9-Anthr-yl)-1-(4-fluoro-phen-yl)-2-(4-nitro-1H-imidazol-1-yl)prop-2-en-1-one.

Authors:  Xiao-Ling Wang; Guang-Zhou Wang; Rong-Xia Geng; Cheng-He Zhou
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-01-09

8.  Structural and spectral investigations of the recently synthesized chalcone (E)-3-mesityl-1-(naphthalen-2-yl) prop-2-en-1-one, a potential chemotherapeutic agent.

Authors:  Assem Barakat; Abdullah Mohammed Al-Majid; Saied M Soliman; Yahia Nasser Mabkhot; M Ali; Hazem A Ghabbour; Hoong-Kun Fun; Abdul Wadood
Journal:  Chem Cent J       Date:  2015-06-13       Impact factor: 4.215

9.  Aurones: a promising heterocyclic scaffold for the development of potent antileishmanial agents.

Authors:  Marina Roussaki; Sofia Costa Lima; Anna-Maria Kypreou; Panagiotis Kefalas; Anabela Cordeiro da Silva; Anastasia Detsi
Journal:  Int J Med Chem       Date:  2012-09-25

Review 10.  Pain Perception and Management: Where do We Stand?

Authors:  Bilal Afridi; Haroon Khan; Esra K Akkol; Michael Aschner
Journal:  Curr Mol Pharmacol       Date:  2021       Impact factor: 3.339
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