| Literature DB >> 19837132 |
Geoffroy Laumet1, Vincent Petitprez, Adeline Sillaire, Anne-Marie Ayral, Franck Hansmannel, Julien Chapuis, Didier Hannequin, Florence Pasquier, Elio Scarpini, Daniela Galimberti, Corinne Lendon, Dominique Campion, Philippe Amouyel, Jean-Charles Lambert.
Abstract
Several observations suggest that neurotoxicity in Alzheimer's disease (AD) can be partly attributed to beta-amyloid (Abeta) and senile plaques. Recent work has suggested that the FISH (five SH3 domains) adapter protein and ADAM12 (a disintegrin and metalloprotease) may mediate the neurotoxic effect of Abeta. Both genes are located on chromosome 10, within a region linked to AD (for SH3PXD2A) or nearby (for ADAM12). A recent study reported a statistically significant interaction between 2 variants of these genes (rs3740473 for SH3PXD2A and rs11244787 for ADAM12) with respect to the risk of developing AD. With a view to replicating this observation, we genotyped the two SNPs in four European case-control cohorts of Caucasian origin (1913 cases and 1468 controls) but were unable to confirm the initial results.Entities:
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Year: 2009 PMID： 19837132 DOI： 10.1016/j.neulet.2009.10.040
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046