Literature DB >> 19818705

Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence.

Peter D Adams1.   

Abstract

Cellular senescence is a proliferation arrest that is typically irreversible and caused by various cellular stresses, including excess rounds of cell division and cancer-causing genetic alterations. Senescence actively contributes to a tissue-level response to tissue wounding and incipient cancer, healing the tissue and suppressing tumor formation. However, in the long term, the same senescence program may hurt the tissue, thereby contributing to tissue aging. Tumor suppression, wound healing, and aging are each associated with inflammation, and here it is proposed that cellular senescence contributes to a "nonimmune cell" component of the tissue inflammatory response.

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Year:  2009        PMID： 19818705     DOI： 10.1016/j.molcel.2009.09.021

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  153 in total

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7.  Human regulatory T cells induce T-lymphocyte senescence.

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Journal:  Blood       Date:  2012-06-21       Impact factor: 22.113

8.  Bisphosphonates induce senescence in normal human oral keratinocytes.

Authors:  R H Kim; R S Lee; D Williams; S Bae; J Woo; M Lieberman; J-E Oh; Q Dong; K-H Shin; M K Kang; N-H Park
Journal:  J Dent Res       Date:  2011-03-22       Impact factor: 6.116

9.  Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

Authors:  Ok Hee Jeon; Chaekyu Kim; Remi-Martin Laberge; Marco Demaria; Sona Rathod; Alain P Vasserot; Jae Wook Chung; Do Hun Kim; Yan Poon; Nathaniel David; Darren J Baker; Jan M van Deursen; Judith Campisi; Jennifer H Elisseeff
Journal:  Nat Med       Date:  2017-04-24       Impact factor: 53.440

10.  Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia.

Authors:  Anastasia Tsaalbi-Shtylik; Johan W A Verspuy; Jacob G Jansen; Heggert Rebel; Leone M Carlée; Martin A van der Valk; Jos Jonkers; Frank R de Gruijl; Niels de Wind
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-10       Impact factor: 11.205
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