Literature DB >> 19817384

Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

Emeline L Maillet1, Robert F Margolskee, Bedrich Mosinger.   

Abstract

We show that phenoxyauxin herbicides and lipid-lowering fibrates inhibit human but not rodent T1R3. T1R3 as a coreceptor in taste cells responds to sweet compounds and amino acids; in endocrine cells of gut and pancreas T1R3 contributes to glucose sensing. Thus, certain effects of fibrates in treating hyperlipidemia and type II diabetes may be via actions on T1R3. Likewise, phenoxy herbicides may have adverse metabolic effects in humans that would have gone undetected in studies on rodents.

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Year:  2009        PMID： 19817384      PMCID： PMC2783803          DOI： 10.1021/jm900823s

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  30 in total

Review 1.  The PPARs: from orphan receptors to drug discovery.

Authors:  T M Willson; P J Brown; D D Sternbach; B R Henke
Journal:  J Med Chem       Date:  2000-02-24       Impact factor: 7.446

Review 2.  Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery.

Authors:  Richard A Bond; Ad P Ijzerman
Journal:  Trends Pharmacol Sci       Date:  2006-01-06       Impact factor: 14.819

3.  Evolution of the sweetness receptor in primates. II. Gustatory responses of non-human primates to nine compounds known to be sweet in man.

Authors:  C Nofre; J M Tinti; D Glaser
Journal:  Chem Senses       Date:  1996-12       Impact factor: 3.160

4.  Different functional roles of T1R subunits in the heteromeric taste receptors.

Authors:  Hong Xu; Lena Staszewski; Huixian Tang; Elliot Adler; Mark Zoller; Xiaodong Li
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-07       Impact factor: 11.205

5.  Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2.

Authors:  Oliver J Mace; Julie Affleck; Nick Patel; George L Kellett
Journal:  J Physiol       Date:  2007-05-10       Impact factor: 5.182

Review 6.  Gymnema sylvestre for diabetes mellitus: a systematic review.

Authors:  Matthew J Leach
Journal:  J Altern Complement Med       Date:  2007-11       Impact factor: 2.579

Review 7.  Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing.

Authors:  Catia Sternini; Laura Anselmi; Enrique Rozengurt
Journal:  Curr Opin Endocrinol Diabetes Obes       Date:  2008-02       Impact factor: 3.243

8.  Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor.

Authors:  Marcel Winnig; Bernd Bufe; Wolfgang Meyerhof
Journal:  BMC Neurosci       Date:  2005-04-07       Impact factor: 3.288

9.  The sweet taste quality is linked to a cluster of taste fibers in primates: lactisole diminishes preference and responses to sweet in S fibers (sweet best) chorda tympani fibers of M. fascicularis monkey.

Authors:  Yiwen Wang; Vicktoria Danilova; Tiffany Cragin; Thomas W Roberts; Alexey Koposov; Göran Hellekant
Journal:  BMC Physiol       Date:  2009-02-18

10.  Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.

Authors:  Hyeung-Jin Jang; Zaza Kokrashvili; Michael J Theodorakis; Olga D Carlson; Byung-Joon Kim; Jie Zhou; Hyeon Ho Kim; Xiangru Xu; Sic L Chan; Magdalena Juhaszova; Michel Bernier; Bedrich Mosinger; Robert F Margolskee; Josephine M Egan
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-27       Impact factor: 11.205
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  11 in total

Review 1.  Minireview: Nutrient sensing by G protein-coupled receptors.

Authors:  Eric M Wauson; Andrés Lorente-Rodríguez; Melanie H Cobb
Journal:  Mol Endocrinol       Date:  2013-07-02

2.  Lipid-Lowering Pharmaceutical Clofibrate Inhibits Human Sweet Taste.

Authors:  Matthew Kochem; Paul A S Breslin
Journal:  Chem Senses       Date:  2016-10-14       Impact factor: 3.160

3.  Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility.

Authors:  Bedrich Mosinger; Kevin M Redding; M Rockwell Parker; Valeriya Yevshayeva; Karen K Yee; Katerina Dyomina; Yan Li; Robert F Margolskee
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-01       Impact factor: 11.205

4.  The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.

Authors:  Eric M Wauson; Elma Zaganjor; A-Young Lee; Marcy L Guerra; Anwesha B Ghosh; Angie L Bookout; Chris P Chambers; Arif Jivan; Kathleen McGlynn; Michele R Hutchison; Ralph J Deberardinis; Melanie H Cobb
Journal:  Mol Cell       Date:  2012-09-06       Impact factor: 17.970

5.  Pharmacology of the Umami Taste Receptor.

Authors:  Guy Servant; Eric Frerot
Journal:  Handb Exp Pharmacol       Date:  2022

Review 6.  Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology.

Authors:  Marilena Gilca; Dorin Dragos
Journal:  Evid Based Complement Alternat Med       Date:  2017-05-31       Impact factor: 2.629

7.  Clofibrate inhibits the umami-savory taste of glutamate.

Authors:  Matthew Kochem; Paul A S Breslin
Journal:  PLoS One       Date:  2017-03-01       Impact factor: 3.240

8.  Asymmetric Synthesis of Photophore-Containing Lactisole Derivatives to Elucidate Sweet Taste Receptors.

Authors:  Tomoya Nakagita; Akiko Ishida; Zetryana Puteri Tachrim; Lei Wang; Takumi Misaka; Makoto Hashimoto
Journal:  Molecules       Date:  2020-06-17       Impact factor: 4.411

9.  Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor.

Authors:  Tomoya Nakagita; Akiko Ishida; Takumi Matsuya; Takuya Kobayashi; Masataka Narukawa; Takatsugu Hirokawa; Makoto Hashimoto; Takumi Misaka
Journal:  PLoS One       Date:  2019-03-18       Impact factor: 3.240

10.  Fenofibrate and Impaired Taste Perception in Type 2 Diabetes.

Authors:  Timothy M E Davis
Journal:  Am J Case Rep       Date:  2020-11-20
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