Literature DB >> 19797663

Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae.

Stephanie A Blandin1, Rui Wang-Sattler, Marina Lamacchia, Julien Gagneur, Gareth Lycett, Ye Ning, Elena A Levashina, Lars M Steinmetz.   

Abstract

The ability of Anopheles gambiae mosquitoes to transmit Plasmodium parasites is highly variable between individuals. However, the genetic basis of this variability has remained unknown. We combined genome-wide mapping and reciprocal allele-specific RNA interference (rasRNAi) to identify the genomic locus that confers resistance to malaria parasites and demonstrated that polymorphisms in a single gene encoding the antiparasitic thioester-containing protein 1 (TEP1) explain a substantial part of the variability in parasite killing. The link between TEP1 alleles and resistance to malaria may offer new tools for controlling malaria transmission. The successful application of rasRNAi in Anopheles suggests that it could also be applied to other organisms where RNAi is feasible to dissect complex phenotypes to the level of individual quantitative trait alleles.

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Year:  2009        PMID： 19797663      PMCID： PMC2959166          DOI： 10.1126/science.1175241

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  21 in total

1.  Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae.

Authors:  E A Levashina; L F Moita; S Blandin; G Vriend; M Lagueux; F C Kafatos
Journal:  Cell       Date:  2001-03-09       Impact factor: 41.582

2.  A genetic study of a melanization response to Sephadex beads in Plasmodium-refractory and -susceptible strains of Anopheles gambiae.

Authors:  M J Gorman; S M Paskewitz
Journal:  Am J Trop Med Hyg       Date:  1997-04       Impact factor: 2.345

3.  Quantitative trait loci for refractoriness of Anopheles gambiae to Plasmodium cynomolgi B.

Authors:  L Zheng; A J Cornel; R Wang; H Erfle; H Voss; W Ansorge; F C Kafatos; F H Collins
Journal:  Science       Date:  1997-04-18       Impact factor: 47.728

4.  Plasmodium gallinaceum: a refractory mechanism of ookinete killing in the mosquito, Anopheles gambiae.

Authors:  K D Vernick; H Fujioka; D C Seeley; B Tandler; M Aikawa; L H Miller
Journal:  Exp Parasitol       Date:  1995-06       Impact factor: 2.011

5.  Genetic selection of a Plasmodium-refractory strain of the malaria vector Anopheles gambiae.

Authors:  F H Collins; R K Sakai; K D Vernick; S Paskewitz; D C Seeley; L H Miller; W E Collins; C C Campbell; R W Gwadz
Journal:  Science       Date:  1986-10-31       Impact factor: 47.728

6.  A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle.

Authors:  Blandine Franke-Fayard; Holly Trueman; Jai Ramesar; Jacqui Mendoza; Maarten van der Keur; Reinier van der Linden; Robert E Sinden; Andrew P Waters; Chris J Janse
Journal:  Mol Biochem Parasitol       Date:  2004-09       Impact factor: 1.759

7.  Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae.

Authors:  Stephanie Blandin; Shin-Hong Shiao; Luis F Moita; Chris J Janse; Andrew P Waters; Fotis C Kafatos; Elena A Levashina
Journal:  Cell       Date:  2004-03-05       Impact factor: 41.582

8.  Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population.

Authors:  Oumou Niaré; Kyriacos Markianos; Jennifer Volz; Frederick Oduol; Abdoulaye Touré; Magaran Bagayoko; Djibril Sangaré; Sekou F Traoré; Rui Wang; Claudia Blass; Guimogo Dolo; Madama Bouaré; Fotis C Kafatos; Leonid Kruglyak; Yeya T Touré; Kenneth D Vernick
Journal:  Science       Date:  2002-10-04       Impact factor: 47.728

9.  Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites.

Authors:  Michael Povelones; Robert M Waterhouse; Fotis C Kafatos; George K Christophides
Journal:  Science       Date:  2009-03-05       Impact factor: 47.728

10.  Quantitative trait loci in Anopheles gambiae controlling the encapsulation response against Plasmodium cynomolgi Ceylon.

Authors:  Liangbiao Zheng; Shuang Wang; Patricia Romans; Hongyu Zhao; Coralia Luna; Mark Q Benedict
Journal:  BMC Genet       Date:  2003-10-24       Impact factor: 2.797
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  60 in total

1.  The role of hemocytes in Anopheles gambiae antiplasmodial immunity.

Authors:  Jose Luis Ramirez; Lindsey S Garver; Fábio André Brayner; Luiz Carlos Alves; Janneth Rodrigues; Alvaro Molina-Cruz; Carolina Barillas-Mury
Journal:  J Innate Immun       Date:  2013-07-24       Impact factor: 7.349

Review 2.  RNAi screening: new approaches, understandings, and organisms.

Authors:  Stephanie E Mohr; Norbert Perrimon
Journal:  Wiley Interdiscip Rev RNA       Date:  2011-09-22       Impact factor: 9.957

3.  Some strains of Plasmodium falciparum, a human malaria parasite, evade the complement-like system of Anopheles gambiae mosquitoes.

Authors:  Alvaro Molina-Cruz; Randall J DeJong; Corrie Ortega; Ashley Haile; Ekua Abban; Janneth Rodrigues; Giovanna Jaramillo-Gutierrez; Carolina Barillas-Mury
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-23       Impact factor: 11.205

4.  Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae.

Authors:  Chris M Cirimotich; Yuemei Dong; April M Clayton; Simone L Sandiford; Jayme A Souza-Neto; Musapa Mulenga; George Dimopoulos
Journal:  Science       Date:  2011-05-13       Impact factor: 47.728

5.  Transfection and mutagenesis of target genes in mosquito cells by locked nucleic acid-modified oligonucleotides.

Authors:  Nazzy Pakpour; Kong Wai Cheung; Lattha Souvannaseng; Jean-Paul Concordet; Shirley Luckhart
Journal:  J Vis Exp       Date:  2010-12-26       Impact factor: 1.355

6.  Chromosomal inversions and ecotypic differentiation in Anopheles gambiae: the perspective from whole-genome sequencing.

Authors:  R Rebecca Love; Aaron M Steele; Mamadou B Coulibaly; Sékou F Traore; Scott J Emrich; Michael C Fontaine; Nora J Besansky
Journal:  Mol Ecol       Date:  2016-11-09       Impact factor: 6.185

Review 7.  Towards the elements of successful insect RNAi.

Authors:  Jeffrey G Scott; Kristin Michel; Lyric C Bartholomay; Blair D Siegfried; Wayne B Hunter; Guy Smagghe; Kun Yan Zhu; Angela E Douglas
Journal:  J Insect Physiol       Date:  2013-09-13       Impact factor: 2.354

8.  A large repertoire of parasite epitopes matched by a large repertoire of host immune receptors in an invertebrate host/parasite model.

Authors:  Yves Moné; Benjamin Gourbal; David Duval; Louis Du Pasquier; Sylvie Kieffer-Jaquinod; Guillaume Mitta
Journal:  PLoS Negl Trop Dis       Date:  2010-09-07

9.  Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae.

Authors:  Zakaria Kambris; Andrew M Blagborough; Sofia B Pinto; Marcus S C Blagrove; H Charles J Godfray; Robert E Sinden; Steven P Sinkins
Journal:  PLoS Pathog       Date:  2010-10-07       Impact factor: 6.823

10.  Polymorphisms in Anopheles gambiae immune genes associated with natural resistance to Plasmodium falciparum.

Authors:  Caroline Harris; Louis Lambrechts; François Rousset; Luc Abate; Sandrine E Nsango; Didier Fontenille; Isabelle Morlais; Anna Cohuet
Journal:  PLoS Pathog       Date:  2010-09-16       Impact factor: 6.823
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