Literature DB >> 9103203

Quantitative trait loci for refractoriness of Anopheles gambiae to Plasmodium cynomolgi B.

L Zheng1, A J Cornel, R Wang, H Erfle, H Voss, W Ansorge, F C Kafatos, F H Collins.   

Abstract

The severity of the malaria pandemic in the tropics is aggravated by the ongoing spread of parasite resistance to antimalarial drugs and mosquito resistance to insecticides. A strain of Anopheles gambiae, normally a major vector for human malaria in Africa, can encapsulate and kill the malaria parasites within a melanin-rich capsule in the mosquito midgut. Genetic mapping revealed one major and two minor quantitative trait loci (QTLs) for this encapsulation reaction. Understanding such antiparasite mechanisms in mosquitoes may lead to new strategies for malaria control.

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Year:  1997        PMID： 9103203     DOI： 10.1126/science.276.5311.425

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  48 in total

Review 1.  Genetics of mosquito vector competence.

Authors:  B T Beerntsen; A A James; B M Christensen
Journal:  Microbiol Mol Biol Rev       Date:  2000-03       Impact factor: 11.056

2.  Anopheles gambiae pilot gene discovery project: identification of mosquito innate immunity genes from expressed sequence tags generated from immune-competent cell lines.

Authors:  G Dimopoulos; T L Casavant; S Chang; T Scheetz; C Roberts; M Donohue; J Schultz; V Benes; P Bork; W Ansorge; M B Soares; F C Kafatos
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

3.  Comparative genomic analysis in the region of a major Plasmodium-refractoriness locus of Anopheles gambiae.

Authors:  Dana Thomasova; Lucas Q Ton; Richard R Copley; Evgeny M Zdobnov; Xuelan Wang; Young S Hong; Cheolho Sim; Peer Bork; Fotis C Kafatos; Frank H Collins
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-11       Impact factor: 11.205

4.  Identification of quantitative trait loci controlling acute virulence in Toxoplasma gondii.

Authors:  Chunlei Su; Daniel K Howe; J P Dubey; James W Ajioka; L David Sibley
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-29       Impact factor: 11.205

5.  A cell surface mucin specifically expressed in the midgut of the malaria mosquito Anopheles gambiae.

Authors:  Z Shen; G Dimopoulos; F C Kafatos; M Jacobs-Lorena
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205

6.  Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes.

Authors:  A M Richman; G Dimopoulos; D Seeley; F C Kafatos
Journal:  EMBO J       Date:  1997-10-15       Impact factor: 11.598

7.  Mapping quantitative trait loci in noninbred mosquito crosses.

Authors:  Shuang Wang; Song Huang; Liangbiao Zheng; Hongyu Zhao
Journal:  Genetics       Date:  2006-01-16       Impact factor: 4.562

8.  An important step forward in the genetic manipulation of mosquito vectors of human disease.

Authors:  M G Kidwell; A R Wattam
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-31       Impact factor: 11.205

9.  Anopheles immune genes and amino acid sites evolving under the effect of positive selection.

Authors:  Aristeidis Parmakelis; Marina Moustaka; Nikolaos Poulakakis; Christos Louis; Michel A Slotman; Jonathon C Marshall; Parfait H Awono-Ambene; Christophe Antonio-Nkondjio; Frederic Simard; Adalgisa Caccone; Jeffrey R Powell
Journal:  PLoS One       Date:  2010-01-26       Impact factor: 3.240

10.  Molecular evolution of immune genes in the malaria mosquito Anopheles gambiae.

Authors:  Tovi Lehmann; Jen C C Hume; Monica Licht; Christopher S Burns; Kurt Wollenberg; Fred Simard; Jose' M C Ribeiro
Journal:  PLoS One       Date:  2009-02-23       Impact factor: 3.240
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