| Literature DB >> 12364806 |
Oumou Niaré1, Kyriacos Markianos, Jennifer Volz, Frederick Oduol, Abdoulaye Touré, Magaran Bagayoko, Djibril Sangaré, Sekou F Traoré, Rui Wang, Claudia Blass, Guimogo Dolo, Madama Bouaré, Fotis C Kafatos, Leonid Kruglyak, Yeya T Touré, Kenneth D Vernick.
Abstract
Successful propagation of the malaria parasite Plasmodium falciparum within a susceptible mosquito vector is a prerequisite for the transmission of malaria. A field-based genetic analysis of the major human malaria vector, Anopheles gambiae, has revealed natural factors that reduce the transmission of P. falciparum. Differences in P. falciparum oocyst numbers between mosquito isofemale families fed on the same infected blood indicated a large genetic component affecting resistance to the parasite, and genome-wide scanning in pedigrees of wild mosquitoes detected segregating resistance alleles. The apparently high natural frequency of resistance alleles suggests that malaria parasites (or a similar pathogen) exert a significant selective pressure on vector populations.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12364806 DOI： 10.1126/science.1073420
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728