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Literature DB >> 1979677

The octamer binding factor Oct6: cDNA cloning and expression in early embryonic cells.

D Meijer¹, A Graus, R Kraay, A Langeveld, M P Mulder, G Grosveld.

Abstract

We have cloned a cDNA encoding a novel octamer binding factor Oct6 that is expressed in undifferentiated ES cells. Expression of the Oct6 gene is downregulated upon differentiation of these cells by aggregate formation. Furthermore the gene is transiently up regulated during retinoic acid induced differentiation of P19 EC cells, reaching maximum levels of expression one day after RA addition. Sequence analysis of the cDNA encoding the Oct6 protein indicated that the Oct6 gene is a member of the POU-HOMEO domain gene family. The gene expresses a 3 kb mRNA encoding a 449 amino acid protein with an apparent molecular weight of 45 kD. The sequence of the Oct6 POU domain is identical to that of the rat SCIP (Tst-1) gene. The Oct6 expression pattern suggests a role for this DNA binding protein in neurogenesis as well as early embryogenesis.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1990 PMID： 1979677 PMCID： PMC332873 DOI： 10.1093/nar/18.24.7357

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

45 in total

Review 1. An inquiry into the mechanisms of herpes simplex virus latency.

Authors: B Roizman; A E Sears
Journal: Annu Rev Microbiol Date: 1987 Impact factor: 15.500

2. Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter.

Authors: A Barberis; G Superti-Furga; M Busslinger
Journal: Cell Date: 1987-07-31 Impact factor: 41.582

3. The interplay of DNA-binding proteins on the promoter of the mouse albumin gene.

Authors: S Lichtsteiner; J Wuarin; U Schibler
Journal: Cell Date: 1987-12-24 Impact factor: 41.582

4. Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation.

Authors: P O'Hare; C R Goding
Journal: Cell Date: 1988-02-12 Impact factor: 41.582

5. Differentiation and maturation of embryonal carcinoma-derived neurons in cell culture.

Authors: M W McBurney; K R Reuhl; A I Ally; S Nasipuri; J C Bell; J Craig
Journal: J Neurosci Date: 1988-03 Impact factor: 6.167

6. SCIP: a glial POU domain gene regulated by cyclic AMP.

Authors: E S Monuki; G Weinmaster; R Kuhn; G Lemke
Journal: Neuron Date: 1989-12 Impact factor: 17.173

7. Four murine c-abl mRNAs arise by usage of two transcriptional promoters and alternative splicing.

Authors: A Bernards; M Paskind; D Baltimore
Journal: Oncogene Date: 1988-04 Impact factor: 9.867

8. Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element.

Authors: F LaBella; H L Sive; R G Roeder; N Heintz
Journal: Genes Dev Date: 1988-01 Impact factor: 11.361

9. Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer.

Authors: T Gerster; P Matthias; M Thali; J Jiricny; W Schaffner
Journal: EMBO J Date: 1987-05 Impact factor: 11.598

10. Molecular characterization of the testis specific c-abl mRNA in mouse.

Authors: D Meijer; A Hermans; M von Lindern; T van Agthoven; A de Klein; P Mackenbach; A Grootegoed; D Talarico; G Della Valle; G Grosveld
Journal: EMBO J Date: 1987-12-20 Impact factor: 11.598

51 in total

1. A distal Schwann cell-specific enhancer mediates axonal regulation of the Oct-6 transcription factor during peripheral nerve development and regeneration.

Authors: W Mandemakers; R Zwart; M Jaegle; E Walbeehm; P Visser; F Grosveld; D Meijer
Journal: EMBO J Date: 2000-06-15 Impact factor: 11.598

2. A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration.

Authors: Merhnaz Ghazvini; Wim Mandemakers; Martine Jaegle; Marko Piirsoo; Siska Driegen; Manousos Koutsourakis; Xsander Smit; Frank Grosveld; Dies Meijer
Journal: EMBO J Date: 2002-09-02 Impact factor: 11.598

The octamer binding factor Oct6: cDNA cloning and expression in early embryonic cells.

Review 1. An inquiry into the mechanisms of herpes simplex virus latency.

2. Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter.

3. The interplay of DNA-binding proteins on the promoter of the mouse albumin gene.

4. Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation.

5. Differentiation and maturation of embryonal carcinoma-derived neurons in cell culture.

6. SCIP: a glial POU domain gene regulated by cyclic AMP.

7. Four murine c-abl mRNAs arise by usage of two transcriptional promoters and alternative splicing.

8. Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element.

9. Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer.

10. Molecular characterization of the testis specific c-abl mRNA in mouse.

1. A distal Schwann cell-specific enhancer mediates axonal regulation of the Oct-6 transcription factor during peripheral nerve development and regeneration.

2. A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration.

3. The gene for the POU domain transcription factor Oct-6 maps to the distal end of mouse chromosome 4.

4. The Oct-1 POU domain mediates interactions between Oct-1 and other POU proteins.

5. POU domain transcription factors from different subclasses stimulate adenovirus DNA replication.

6. The downstream regulatory sequence of the adenovirus type 2 major late promoter is functionally redundant.

7. New nucleotide sequence data on the EMBL File Server.

8. Structure and evolution of four POU domain genes expressed in mouse brain.

9. Nucleotide sequence of XLPOU3 cDNA, a member of the POU domain gene family expressed in Xenopus laevis embryos.

10. Mapping the transactivation domain of the Oct-6 POU transcription factor.