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Literature DB >> 1346336

The Oct-1 POU domain mediates interactions between Oct-1 and other POU proteins.

C P Verrijzer¹, J A van Oosterhout, P C van der Vliet.

Abstract

The POU domain is the conserved DNA binding domain of a family of gene regulatory proteins. It consists of a POU-specific domain and a POU homeodomain, connected by a variable linker region. Oct-1 is a ubiquitously expressed POU domain transcription factor. It binds to the canonical octamer sequence (ATGCAAAT) as a monomer. Here we show by chemical cross-linking and protein affinity chromatography that the Oct-1 POU domain monomers can interact in solution. This association requires both the POU homeodomain and the POU-specific domain. The interaction is transient in solution and can be stabilized by binding to the heptamer-octamer sequence in the immunoglobulin heavy-chain promoter. This correlates with cooperative DNA binding to this site. POU proteins from different subclasses, including Oct-1, Oct-2A, Oct-6, and a chimeric Oct-1 protein containing the Pit-1 POU domain, can bind cooperatively to a double binding site and form a heteromeric complex.

Entities: Gene

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Year: 1992 PMID： 1346336 PMCID： PMC364225 DOI： 10.1128/mcb.12.2.542-551.1992

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

67 in total

1. Transcription factors NFI and NFIII/oct-1 function independently, employing different mechanisms to enhance adenovirus DNA replication.

Authors: Y M Mul; C P Verrijzer; P C van der Vliet
Journal: J Virol Date: 1990-11 Impact factor: 5.103

Review 2. Herpes simplex virus Vmw65-octamer binding protein interaction: a paradigm for combinatorial control of transcription.

Authors: C R Goding; P O'Hare
Journal: Virology Date: 1989-12 Impact factor: 3.616

3. Purified octamer binding transcription factors stimulate RNA polymerase III--mediated transcription of the 7SK RNA gene.

Authors: S Murphy; A Pierani; C Scheidereit; M Melli; R G Roeder
Journal: Cell Date: 1989-12-22 Impact factor: 41.582

4. The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16.

Authors: S Stern; M Tanaka; W Herr
Journal: Nature Date: 1989-10-19 Impact factor: 49.962

5. Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements.

Authors: S Y Tsai; M J Tsai; B W O'Malley
Journal: Cell Date: 1989-05-05 Impact factor: 41.582

6. Synergistic activation by the glutamine-rich domains of human transcription factor Sp1.

Authors: A J Courey; D A Holtzman; S P Jackson; R Tjian
Journal: Cell Date: 1989-12-01 Impact factor: 41.582

7. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype.

Authors: H A Ingraham; R P Chen; H J Mangalam; H P Elsholtz; S E Flynn; C R Lin; D M Simmons; L Swanson; M G Rosenfeld
Journal: Cell Date: 1988-11-04 Impact factor: 41.582

8. Bending of DNA by gene-regulatory proteins: construction and use of a DNA bending vector.

Authors: J Kim; C Zwieb; C Wu; S Adhya
Journal: Gene Date: 1989-12-21 Impact factor: 3.688

9. Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells.

Authors: M M Müller-Immerglück; W Schaffner; P Matthias
Journal: EMBO J Date: 1990-05 Impact factor: 11.598

10. Octamer transcription factors bind to two different sequence motifs of the immunoglobulin heavy chain promoter.

Authors: I Kemler; E Schreiber; M M Müller; P Matthias; W Schaffner
Journal: EMBO J Date: 1989-07 Impact factor: 11.598

39 in total

1. Combination of a zinc finger and homeodomain required for protein-interaction.

Authors: Gregory E Smith; Douglas S Darling
Journal: Mol Biol Rep Date: 2003-12 Impact factor: 2.316

2. A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells.

Authors: K A Lillycrop; V S Budrahan; N D Lakin; G Terrenghi; J N Wood; J M Polak; D S Latchman
Journal: Nucleic Acids Res Date: 1992-10-11 Impact factor: 16.971

3. POU domain transcription factors from different subclasses stimulate adenovirus DNA replication.

Authors: C P Verrijzer; M Strating; Y M Mul; P C van der Vliet
Journal: Nucleic Acids Res Date: 1992-12-11 Impact factor: 16.971

Review 4. The Oct1 transcription factor and epithelial malignancies: Old protein learns new tricks.

Authors: Karina Vázquez-Arreguín; Dean Tantin
Journal: Biochim Biophys Acta Date: 2016-02-10

5. Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites.

Authors: D C Ambrosetti; C Basilico; L Dailey
Journal: Mol Cell Biol Date: 1997-11 Impact factor: 4.272

6. Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus.

Authors: C P Chang; L Brocchieri; W F Shen; C Largman; M L Cleary
Journal: Mol Cell Biol Date: 1996-04 Impact factor: 4.272

7. Shared promoter elements between a viral superantigen and the major histocompatibility complex class II-associated invariant chain.

Authors: J Arroyo; E Winchester; B S McLellan; B T Huber
Journal: J Virol Date: 1997-02 Impact factor: 5.103