Literature DB >> 19789690

A genome wide association analysis in the GENDER study.

M L Sampietro1, D Pons, P de Knijff, P E Slagboom, A Zwinderman, J W Jukema.   

Abstract

Percutaneous coronary intervention (PCI) has become an effective therapy to treat coronary artery diseases. However, one of the major drawbacks of PCI is the occurrence of restenosis in 8 to 40% of all treated patients. The GENetic Determinants of Restenosis (GENDER) project was designed to study the association between genetic polymorphisims and clinical restenosis. The discovery of genetic variants associated to the occurrence of restenosis after PCI may provide a more tailored therapy and may serve as rationale for new antirestenotic therapies. So far, several candidate gene approaches had already been performed in the GENDER samples but a Genome Wide Association Scan (GWAS) was still lacking. Here, we present preliminary results from the GWAS we are currently carrying out in the GENDER population. (Neth Heart J 2009;17:262-4.).

Entities:  

Year:  2009        PMID： 19789690      PMCID： PMC2711253          DOI： 10.1007/BF03086261

Source DB:  PubMed          Journal:  Neth Heart J        ISSN： 1568-5888            Impact factor:   2.380


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2.  A genome wide association analysis in the GENDER study.

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