Literature DB >> 1978671

Glutamine-synthesizing activity in lungs of fed, starved, acidotic, diabetic, injured and septic rats.

M S Ardawi1.   

Abstract

The maximal catalytic activity of glutamine synthetase was measured in lung homogenates of the rat (being 5.46 +/- 0.29 mumol/min per g wet wt. or 31.70 +/- 2.62 nmol/min per mg of protein at 37 degrees C, in fed animals). The activity is similar to that of liver, but 16-fold higher than that in quadriceps muscles. Chronic (NH4Cl-induced) or acute (HCl-induced) metabolic acidosis had no effects on enzyme activity, but there was a marked increase in the activity of glutamine synthetase in starved (30-40%), streptozotocin-diabetic (17%), dexamethasone-treated (18-22%), laparotomized (25-27%) and septic rats (24-45%).

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Year:  1990        PMID： 1978671      PMCID： PMC1131809          DOI： 10.1042/bj2700829

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  15 in total

1.  Metabolic control of hepatic gluconeogenesis in response to sepsis.

Authors:  M S Ardawi; A A Ashy; Y S Jamal; S M Khoja
Journal:  J Lab Clin Med       Date:  1989-11

2.  The influence of abdominal surgical trauma on the exchange of blood-borne amino acids in the human leg.

Authors:  H Stjernström; J Lund; L Wiklund; U Bergholm; E Vinnars; B Hamberger; L Jorfeldt
Journal:  Clin Nutr       Date:  1986-05       Impact factor: 7.324

3.  Skeletal muscle glutamine production in thermally injured rats.

Authors:  M S Ardawi
Journal:  Clin Sci (Lond)       Date:  1988-02       Impact factor: 6.124

4.  Interrelationships between level of amino acids in plasma and tissues during starvation.

Authors:  S A Adibi
Journal:  Am J Physiol       Date:  1971-09

Review 5.  Metabolism in lymphocytes and its importance in the immune response.

Authors:  M S Ardawi; E A Newsholme
Journal:  Essays Biochem       Date:  1985       Impact factor: 8.000

6.  Glutamine synthetase induction by glucocorticoids in the glucocorticoid-sensitive human leukemic cell line CEM-C7.

Authors:  J M Harmon; E B Thompson
Journal:  J Cell Physiol       Date:  1982-02       Impact factor: 6.384

7.  A radiochemical assay for glutamine synthetase, and activity of the enzyme in rat tissues.

Authors:  P Lund
Journal:  Biochem J       Date:  1970-06       Impact factor: 3.857

8.  Effect of glucocorticoid treatment on glucose and glutamine metabolism by the small intestine of the rat.

Authors:  M Salleh; M Ardawi; M F Majzoub; E A Newsholme
Journal:  Clin Sci (Lond)       Date:  1988-07       Impact factor: 6.124

9.  Glutamine metabolism in skeletal muscle of glucocorticoid-treated rats.

Authors:  M S Ardawi; Y S Jamal
Journal:  Clin Sci (Lond)       Date:  1990-08       Impact factor: 6.124

10.  Accelerated lung amino acid release in hyperdynamic septic surgical patients.

Authors:  D A Plumley; W W Souba; R D Hautamaki; T D Martin; T C Flynn; W R Rout; E M Copeland
Journal:  Arch Surg       Date:  1990-01
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  3 in total

Review 1.  The emerging role of glutamine as an indicator of exercise stress and overtraining.

Authors:  D G Rowbottom; D Keast; A R Morton
Journal:  Sports Med       Date:  1996-02       Impact factor: 11.136

2.  Effects of postprandial starvation on mRNA expression of endocrine-, amino acid and peptide transporter-, and metabolic enzyme-related genes in zebrafish (Danio rerio).

Authors:  Juan Tian; Gen He; Kangsen Mai; Chengdong Liu
Journal:  Fish Physiol Biochem       Date:  2015-03-25       Impact factor: 2.794

Review 3.  Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism.

Authors:  Krzysztof Piotr Michalak; Agnieszka Maćkowska-Kędziora; Bogusław Sobolewski; Piotr Woźniak
Journal:  Oxid Med Cell Longev       Date:  2015-10-25       Impact factor: 6.543
  3 in total

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