| Literature DB >> 19785441 |
Dominik Koszelewski1, Desiree Pressnitz, Dorina Clay, Wolfgang Kroutil.
Abstract
(S)- as well as (R)-mexiletine [1-(2,6-dimethylphenoxy)-2-propanamine], a chiral orally effective antiarrhythmic agent, was prepared by deracemization starting from the commercially available racemic amine using omega-transaminases in up to >99% ee and conversion with 97% isolated yield by a one-pot two-step procedure. The absolute configuration could be easily switched to the other enantiomer, just by switching the order of the applied transaminases. The cosubstrate pyruvate needed in the first oxidative step was recycled by using an amino acid oxidase.Entities:
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Year: 2009 PMID： 19785441 DOI： 10.1021/ol901834x
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005