OBJECTIVE: We sought to understand whether obesity imparts detriment in outcome beyond risk of developing surgical site infection (SSI). SUMMARY BACKGROUND DATA: Obesity is a risk factor for SSI following renal transplantation, and has been implicated in inferior patient and graft survival postoperatively. METHODS: We conducted a retrospective review of all adult kidney-only transplants performed at the University of Michigan between September 2003 and April 2008. The primary exposure variable was recipient body mass index (BMI). Cox multivariable regression and Kaplan-Meier analysis were used to identify factors associated with SSI, graft loss, and patient death. RESULTS: In total, 869 recipients were studied, including 351 with BMI >30. Multivariate analysis revealed recipient age, delayed graft function, and BMI >30 to be independent risk factors for SSI. SSI was a significant risk factor for graft loss (HR: 2.194, 95% CI: 1.357-3.546) and approached significance as a risk factor for patient death (HR: 1.689, 95% CI: 0.941-3.028). Obesity had no independent effect on graft or patient outcome. CONCLUSIONS: SSI is associated with detriment to patient and graft survival following renal transplantation. The prevalence of SSI is higher among obese recipients, but those who avoid SSI have comparable outcomes to nonobese recipients. These findings redemonstrate the importance of SSI prevention following renal transplantation.
OBJECTIVE: We sought to understand whether obesity imparts detriment in outcome beyond risk of developing surgical site infection (SSI). SUMMARY BACKGROUND DATA: Obesity is a risk factor for SSI following renal transplantation, and has been implicated in inferior patient and graft survival postoperatively. METHODS: We conducted a retrospective review of all adult kidney-only transplants performed at the University of Michigan between September 2003 and April 2008. The primary exposure variable was recipient body mass index (BMI). Cox multivariable regression and Kaplan-Meier analysis were used to identify factors associated with SSI, graft loss, and patient death. RESULTS: In total, 869 recipients were studied, including 351 with BMI >30. Multivariate analysis revealed recipient age, delayed graft function, and BMI >30 to be independent risk factors for SSI. SSI was a significant risk factor for graft loss (HR: 2.194, 95% CI: 1.357-3.546) and approached significance as a risk factor for patient death (HR: 1.689, 95% CI: 0.941-3.028). Obesity had no independent effect on graft or patient outcome. CONCLUSIONS: SSI is associated with detriment to patient and graft survival following renal transplantation. The prevalence of SSI is higher among obese recipients, but those who avoid SSI have comparable outcomes to nonobese recipients. These findings redemonstrate the importance of SSI prevention following renal transplantation.
Authors: Ernesto P Molmenti; Asha Alex; Lisa Rosen; Mohini Alexander; Jeffrey Nicastro; Jingyan Yang; Eric Siskind; Leesha Alex; Emil Sameyah; Madhu Bhaskaran; Nicole Ali; Amit Basu; Mala Sachdeva; Stergiani Agorastos; Prejith Rajendran; Prathik Krishnan; Poornima Ramadas; Leo Amodu; Joaquin Cagliani; Sameer Rehman; Adam Kressel; Christine B Sethna; Georgios C Sotiropoulos; Arnold Radtke; George Sgourakis; Richard Schwarz; Steven Fishbane; Alessandro Bellucci; Gene Coppa; Horacio Rilo; Christine L Molmenti Journal: Int J Angiol Date: 2015-09-15
Authors: J Oberholzer; P Giulianotti; K K Danielson; M Spaggiari; L Bejarano-Pineda; F Bianco; I Tzvetanov; S Ayloo; H Jeon; R Garcia-Roca; J Thielke; I Tang; S Akkina; B Becker; K Kinzer; A Patel; E Benedetti Journal: Am J Transplant Date: 2013-03 Impact factor: 8.086
Authors: Jordana B Cohen; Mary Ann Lim; Colleen M Tewksbury; Samuel Torres-Landa; Jennifer Trofe-Clark; Peter L Abt; Noel N Williams; Kristoffel R Dumon; Simin Goral Journal: Surg Obes Relat Dis Date: 2019-06 Impact factor: 4.734