Shivashankar Damodaran1,2, Brenna Bullock3,4, Obi Ekwenna5,4, Mehdi Nayebpour6,4, Naoru Koizumi6,4, Puneet Sindhwani5,4, Jorge Ortiz5,4. 1. Department of Urology and Renal Transplant, University of Toledo, 3000, Arlington Ave, MS1091, Toledo, OH, 43614, USA. Shivashankar.damodaran@utoledo.edu. 2. Department of Surgery and Kidney Transplant, University of Toledo, 3000, Arlington Ave, MS1095, Toledo, OH, 43614, USA. Shivashankar.damodaran@utoledo.edu. 3. College of Medicine and Life Sciences, University of Toledo, 3000, Arlington Ave, Toledo, OH, 43614, USA. 4. Department of Surgery and Kidney Transplant, University of Toledo, 3000, Arlington Ave, MS1095, Toledo, OH, 43614, USA. 5. Department of Urology and Renal Transplant, University of Toledo, 3000, Arlington Ave, MS1091, Toledo, OH, 43614, USA. 6. Schar School of Policy and Government, George Mason University, Arlington Campus, Van Metre Hall 520, 3351 N. Fairfax Dr. MS#3B1, Arlington, VA, 22201, USA.
Abstract
BACKGROUND: Delayed graft function (DGF) is a manifestation of acute kidney injury uniquely framed within the transplant process and a predictor of poor long-term graft function1. It is less common in the setting of living donor (LD) kidney transplantation. However, the detrimental impact of DGF on graft survival is more pronounced in LD2. PURPOSE: To study the effects of DGF in the setting of LD kidney transplantation. METHODS: We performed a retrospective analysis of LD kidney transplantations performed between 2010 and 2018 in the UNOS/OPTN database for DGF and its effect on graft survival. RESULTS: A total of 42,736 LD recipients were identified, of whom 1115 (2.6%) developed DGF. Recipient dialysis status, male gender, diabetes, end-stage renal disease, donor age, right donor nephrectomy, panel reactive antibodies, HLA mismatch, and cold ischemia time were independent predictors of DGF. Three-year graft survival in patients with and without DGF was 89% and 95%, respectively. DGF was the greatest predictor of graft failure at three years (hazard ratio = 1.766, 95% CI: 1.514-2.059, P = 0.001) and was associated with higher rates of rejection (9% vs. 6.28%, P = 0.0003). Among patients with DGF, the graft survival rates with and without rejection were not different. CONCLUSION: DGF is a major determinant of poor graft functional outcomes, independent of rejection.
BACKGROUND: Delayed graft function (DGF) is a manifestation of acute kidney injury uniquely framed within the transplant process and a predictor of poor long-term graft function1. It is less common in the setting of living donor (LD) kidney transplantation. However, the detrimental impact of DGF on graft survival is more pronounced in LD2. PURPOSE: To study the effects of DGF in the setting of LD kidney transplantation. METHODS: We performed a retrospective analysis of LD kidney transplantations performed between 2010 and 2018 in the UNOS/OPTN database for DGF and its effect on graft survival. RESULTS: A total of 42,736 LD recipients were identified, of whom 1115 (2.6%) developed DGF. Recipient dialysis status, male gender, diabetes, end-stage renal disease, donor age, right donor nephrectomy, panel reactive antibodies, HLA mismatch, and cold ischemia time were independent predictors of DGF. Three-year graft survival in patients with and without DGF was 89% and 95%, respectively. DGF was the greatest predictor of graft failure at three years (hazard ratio = 1.766, 95% CI: 1.514-2.059, P = 0.001) and was associated with higher rates of rejection (9% vs. 6.28%, P = 0.0003). Among patients with DGF, the graft survival rates with and without rejection were not different. CONCLUSION: DGF is a major determinant of poor graft functional outcomes, independent of rejection.
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