BACKGROUND: To compare the accuracy of combined 64-slice computed tomography angiography (CTA) and stress nuclear myocardial perfusion imaging (MPI) in the noninvasive detection of coronary artery disease (CAD) with that of 64-slice CTA alone. METHODS AND RESULTS: One hundred thirty symptomatic patients with suspected CAD underwent both 64-slice CTA and stress thallium-201 MPI before invasive coronary angiography (ICA). Coronary lesions with >or=50% luminal narrowing were considered as significant stenoses on CTA and ICA. Of 390 arteries in 130 patients, 54 (14%) were nonevaluable by CTA due to severe calcifications, motion artifacts, and/or poor opacification. All nonevaluable arteries were considered positive. The sensitivity, specificity, PPV and NPV were 95%, 80%, 69%, and 97%, respectively, for CTA alone and 94%, 92%, 85%, and 97%, respectively, for CTA with stress nuclear MPI for all nonevaluable arteries on CTA. Per-patient analysis showed significant increase in specificity and PPV. The majority (75%, 9/12) of nonevaluable severely calcified vessels in the left anterior descending artery were positive on stress nuclear MPI, whereas the majority (89%, 8/9) of nonevaluable vessels with motion artifacts in the right coronary artery were negative. CONCLUSIONS: Combined CTA and stress nuclear MPI provide improved diagnostic accuracy for the noninvasive detection of CAD.
BACKGROUND: To compare the accuracy of combined 64-slice computed tomography angiography (CTA) and stress nuclear myocardial perfusion imaging (MPI) in the noninvasive detection of coronary artery disease (CAD) with that of 64-slice CTA alone. METHODS AND RESULTS: One hundred thirty symptomatic patients with suspected CAD underwent both 64-slice CTA and stress thallium-201 MPI before invasive coronary angiography (ICA). Coronary lesions with >or=50% luminal narrowing were considered as significant stenoses on CTA and ICA. Of 390 arteries in 130 patients, 54 (14%) were nonevaluable by CTA due to severe calcifications, motion artifacts, and/or poor opacification. All nonevaluable arteries were considered positive. The sensitivity, specificity, PPV and NPV were 95%, 80%, 69%, and 97%, respectively, for CTA alone and 94%, 92%, 85%, and 97%, respectively, for CTA with stress nuclear MPI for all nonevaluable arteries on CTA. Per-patient analysis showed significant increase in specificity and PPV. The majority (75%, 9/12) of nonevaluable severely calcified vessels in the left anterior descending artery were positive on stress nuclear MPI, whereas the majority (89%, 8/9) of nonevaluable vessels with motion artifacts in the right coronary artery were negative. CONCLUSIONS: Combined CTA and stress nuclear MPI provide improved diagnostic accuracy for the noninvasive detection of CAD.
Authors: Manuel D Cerqueira; Neil J Weissman; Vasken Dilsizian; Alice K Jacobs; Sanjiv Kaul; Warren K Laskey; Dudley J Pennell; John A Rumberger; Thomas Ryan; Mario S Verani Journal: Circulation Date: 2002-01-29 Impact factor: 29.690
Authors: Joanne D Schuijf; William Wijns; J Wouter Jukema; Douwe E Atsma; Albert de Roos; Hildo J Lamb; Marcel P M Stokkel; Petra Dibbets-Schneider; Isabel Decramer; Pieter De Bondt; Ernst E van der Wall; Piet K Vanhoenacker; Jeroen J Bax Journal: J Am Coll Cardiol Date: 2006-11-28 Impact factor: 24.094
Authors: Nico R Mollet; Filippo Cademartiri; Carlos A G van Mieghem; Giuseppe Runza; Eugène P McFadden; Timo Baks; Patrick W Serruys; Gabriel P Krestin; Pim J de Feyter Journal: Circulation Date: 2005-10-03 Impact factor: 29.690
Authors: Marcus Hacker; Tobias Jakobs; Florian Matthiesen; Christian Vollmar; Konstantin Nikolaou; Christoph Becker; Andreas Knez; Thomas Pfluger; Maximilian Reiser; Klaus Hahn; Reinhold Tiling Journal: J Nucl Med Date: 2005-08 Impact factor: 10.057
Authors: R Hachamovitch; D S Berman; L J Shaw; H Kiat; I Cohen; J A Cabico; J Friedman; G A Diamond Journal: Circulation Date: 1998-02-17 Impact factor: 29.690
Authors: Dieter Ropers; Johannes Rixe; Katharina Anders; Axel Küttner; Ulrich Baum; Werner Bautz; Werner G Daniel; Stephan Achenbach Journal: Am J Cardiol Date: 2005-12-01 Impact factor: 2.778
Authors: Julie M Miller; Carlos E Rochitte; Marc Dewey; Armin Arbab-Zadeh; Hiroyuki Niinuma; Ilan Gottlieb; Narinder Paul; Melvin E Clouse; Edward P Shapiro; John Hoe; Albert C Lardo; David E Bush; Albert de Roos; Christopher Cox; Jeffery Brinker; João A C Lima Journal: N Engl J Med Date: 2008-11-27 Impact factor: 91.245
Authors: Elsemiek M Engbers; Jorik R Timmer; Jan Paul Ottervanger; Mohamed Mouden; Ad H J Oostdijk; Siert Knollema; Pieter L Jager Journal: J Nucl Cardiol Date: 2015-09-22 Impact factor: 5.952
Authors: Frank M Bengel; Richard T George; Karl H Schuleri; Albert C Lardo; Kai C Wollert Journal: Eur Heart J Cardiovasc Imaging Date: 2013-05-29 Impact factor: 6.875
Authors: Elsemiek M Engbers; Jorik R Timmer; Mohamed Mouden; Siert Knollema; Pieter L Jager; Jan Paul Ottervanger Journal: Eur Radiol Date: 2016-05-11 Impact factor: 5.315
Authors: Asim Rizvi; Donghee Han; Ibrahim Danad; Bríain Ó Hartaigh; Ji Hyun Lee; Heidi Gransar; Wijnand J Stuijfzand; Hadi Mirhedayati Roudsari; Mahn Won Park; Jackie Szymonifka; Hyuk-Jae Chang; Erica C Jones; Paul Knaapen; Fay Y Lin; James K Min; Jessica M Peña Journal: JACC Cardiovasc Imaging Date: 2017-08-16