AIMS: Left ventricular (LV) shape and LV dyssynchrony are two cofactors associated with functional mitral regurgitation (MR) in patients with heart failure. Both can be accurately examined by real-time three-dimensional echocardiography (3DE). We examined the relationship between dynamic MR and exercise-induced changes in LV shape and synchronicity using 3DE. METHODS AND RESULTS: Fifty patients with systolic LV dysfunction underwent 2D and 3D quantitative assessment of LV function, shape, and synchronicity at rest and during symptom-limited exercise test. According to the magnitude of change in MR, patients were divided into EMR group (15 patients, 30%), if the degree of MR increased during test, and NEMR group. During exercise, the changes in LV volumes and ejection fraction were similar in both groups, whereas changes in mitral valvular deformation parameters, in LV sphericity index, and in the extent of LV dyssynchrony were more pronounced in the EMR group. At rest, only the 3D sphericity index could distinguish the two groups. By stepwise multiple regression model, dynamic changes in the systolic dyssynchrony index, sphericity index, and coaptation distance were associated with dynamic MR (r(2) = 0.45, P = 0.012). CONCLUSION: Dynamic MR during exercise is related to the 3D changes in LV shape and in LV synchronicity.
AIMS: Left ventricular (LV) shape and LV dyssynchrony are two cofactors associated with functional mitral regurgitation (MR) in patients with heart failure. Both can be accurately examined by real-time three-dimensional echocardiography (3DE). We examined the relationship between dynamic MR and exercise-induced changes in LV shape and synchronicity using 3DE. METHODS AND RESULTS: Fifty patients with systolic LV dysfunction underwent 2D and 3D quantitative assessment of LV function, shape, and synchronicity at rest and during symptom-limited exercise test. According to the magnitude of change in MR, patients were divided into EMR group (15 patients, 30%), if the degree of MR increased during test, and NEMR group. During exercise, the changes in LV volumes and ejection fraction were similar in both groups, whereas changes in mitral valvular deformation parameters, in LV sphericity index, and in the extent of LV dyssynchrony were more pronounced in the EMR group. At rest, only the 3D sphericity index could distinguish the two groups. By stepwise multiple regression model, dynamic changes in the systolic dyssynchrony index, sphericity index, and coaptation distance were associated with dynamic MR (r(2) = 0.45, P = 0.012). CONCLUSION: Dynamic MR during exercise is related to the 3D changes in LV shape and in LV synchronicity.
Authors: Xingyu Zhang; Pau Medrano-Gracia; Bharath Ambale-Venkatesh; David A Bluemke; Brett R Cowan; J Paul Finn; Alan H Kadish; Daniel C Lee; Joao A C Lima; Alistair A Young; Avan Suinesiaputra Journal: Gigascience Date: 2017-03-01 Impact factor: 6.524
Authors: Peter M Maloca; Richard F Spaide; Emanuel Ramos de Carvalho; Harald P Studer; Pascal W Hasler; Hendrik P N Scholl; Tjebo F C Heeren; Julia Schottenhamml; Konstantinos Balaskas; Adnan Tufail; Catherine Egan Journal: Graefes Arch Clin Exp Ophthalmol Date: 2020-01-06 Impact factor: 3.117
Authors: Yiu-fai Cheung; Wei Yu; Shu-na Li; Wendy W M Lam; Yuen-chi Ho; Sophia J Wong; Godfrey C F Chan; Shau-yin Ha Journal: PLoS One Date: 2012-09-18 Impact factor: 3.240