Greggory R DeVore1, Percy Pacora Portella2,3, Edgar Hernandez Andrade2,3, Lami Yeo2,3, Roberto Romero2,3,4,5,6,7,8. 1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, California, Los Angeles, USA. 2. Perinatology Research Branch, Divisions of Obstetrics and Maternal-Fetal Medicine and Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Maryland, and Detroit, Bethesda, Michigan, USA. 3. Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA. 4. Department of Obstetrics and Gynecology, University of Michigan Health System, Ann Arbor, Michigan, USA. 5. Department of Epidemiology and Biostatistics, College of Human Medicine, East Lansing, Michigan, USA. 6. Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA. 7. Detroit Medical Center, Detroit, Michigan, USA. 8. Department of Obstetrics and Gynecology, Florida International University, Miami, Florida, USA.
Abstract
OBJECTIVES: The purpose of this study was to evaluate the end-diastolic size and shape of the 4-chamber view as well as the right ventricle (RV) and left ventricle (LV) in growth-restricted fetuses before 34 weeks' gestation with absent or reversed end-diastolic velocity of the umbilical artery and compare the results between those with perinatal deaths and those who survived the neonatal period. METHODS: Forty-nine fetuses with growth restriction and absent or reversed end-diastolic velocity of the umbilical artery were studied. The size, shape, and sphericity index of the 4-chamber view, RV, and LV were assessed. The number and percentage of fetuses with z score values of less than -1.65 and greater than 1.65 were computed. RESULTS: Of the 49 fetuses, there were 13 perinatal deaths (27%) and 36 (63%) neonatal survivors. Measurements that were unique for neonatal survivors were an increased RV apical transverse width and decreased measurements of the following: LV and RV widths, LV and RV areas, as well as RV sphericity indices. CONCLUSIONS: Fetuses with a smaller RV and LV size and area and those with a globular-shaped RV were at significantly lower risk for perinatal death.
OBJECTIVES: The purpose of this study was to evaluate the end-diastolic size and shape of the 4-chamber view as well as the right ventricle (RV) and left ventricle (LV) in growth-restricted fetuses before 34 weeks' gestation with absent or reversed end-diastolic velocity of the umbilical artery and compare the results between those with perinatal deaths and those who survived the neonatal period. METHODS: Forty-nine fetuses with growth restriction and absent or reversed end-diastolic velocity of the umbilical artery were studied. The size, shape, and sphericity index of the 4-chamber view, RV, and LV were assessed. The number and percentage of fetuses with z score values of less than -1.65 and greater than 1.65 were computed. RESULTS: Of the 49 fetuses, there were 13 perinatal deaths (27%) and 36 (63%) neonatal survivors. Measurements that were unique for neonatal survivors were an increased RV apical transverse width and decreased measurements of the following: LV and RV widths, LV and RV areas, as well as RV sphericity indices. CONCLUSIONS: Fetuses with a smaller RV and LV size and area and those with a globular-shaped RV were at significantly lower risk for perinatal death.
Authors: D Mahieu-Caputo; L J Salomon; J Le Bidois; L Fermont; A Brunhes; P Jouvet; Y Dumez; M Dommergues Journal: Prenat Diagn Date: 2003-08 Impact factor: 3.050