AIM: Presenting features, treatment and outcome of 134 newborns with neuroblastoma diagnosed over a 27-year period are described. METHODS: Analyses were performed on the entire cohort and on patients distributed over three periods of diagnosis. RESULTS: Twenty-seven tumours (20.1%) were detected prenatally. Localised disease prevailed (65.7%) with an increase of stage 1 patients over time from 18.8% to 46.5%. Disseminated disease accounted for 34.3% of tumours with only one stage 4 and 45 stage 4S. Five-year overall survival (OS) of the entire cohort was 88.3%. Five/88 patients with localised disease died, including three who died of complications (OS, 95.3%). The only stage 4 patient survived. Eleven/45 stage 4S patients died, including 7/18 symptomatic and 4/27 asymptomatic (OS, 74.1%). CONCLUSION: The outcome of neuroblastoma in newborns is excellent. In localised tumours, surgery-related deaths outnumbered deaths due to disease. Symptomatic stage 4S patients were at greater risk of dying.
AIM: Presenting features, treatment and outcome of 134 newborns with neuroblastoma diagnosed over a 27-year period are described. METHODS: Analyses were performed on the entire cohort and on patients distributed over three periods of diagnosis. RESULTS: Twenty-seven tumours (20.1%) were detected prenatally. Localised disease prevailed (65.7%) with an increase of stage 1 patients over time from 18.8% to 46.5%. Disseminated disease accounted for 34.3% of tumours with only one stage 4 and 45 stage 4S. Five-year overall survival (OS) of the entire cohort was 88.3%. Five/88 patients with localised disease died, including three who died of complications (OS, 95.3%). The only stage 4 patient survived. Eleven/45 stage 4S patients died, including 7/18 symptomatic and 4/27 asymptomatic (OS, 74.1%). CONCLUSION: The outcome of neuroblastoma in newborns is excellent. In localised tumours, surgery-related deaths outnumbered deaths due to disease. Symptomatic stage 4S patients were at greater risk of dying.
Authors: Jed G Nuchtern; Wendy B London; Carol E Barnewolt; Arlene Naranjo; Patrick W McGrady; James D Geiger; Lisa Diller; Mary Lou Schmidt; John M Maris; Susan L Cohn; Robert C Shamberger Journal: Ann Surg Date: 2012-10 Impact factor: 12.969
Authors: A Di Cataldo; A Agodi; J Balaguer; A Garaventa; M Barchitta; V Segura; M Bianchi; V Castel; A Castellano; S Cesaro; J M Couselo; O Cruz; P D'Angelo; B De Bernardi; J Donat; N G de Andoin; M I Hernandez; M La Spina; M Lillo; R Lopez-Almaraz; R Luksch; S Mastrangelo; E Mateos; J Molina; C Moscheo; R Mura; F Porta; G Russo; A Tondo; M Torrent; S Vetrella; J A Villegas; E Viscardi; G A Zanazzo; A Cañete Journal: Clin Transl Oncol Date: 2016-04-04 Impact factor: 3.405