OBJECTIVE: To determine outcome of neuroblastoma (NBL) in children under 18 mo of age who had been treated with national protocols. METHODS: The characteristics and treatment outcomes of 27 children were evaluated retrospectively. RESULTS: The event-free survival (EFS) at 60 and 108 mo were 84.7 % ± 7.7 and 72.6 % ± 7.7, respectively. The overall survival (OS) was 91.7 % ± 8 at 108 mo. The only significant risk factor for OS in children with neuroblastoma was the treatment response at the end of therapy (p = 0.001). "Wait and see" policy was applied to two infants with low risk NBL and one infant with stage 4S neuroblastoma and all 3 of these infants have been in remission at last followup. Four of the five patients with MYCN-amplified neuroblastoma were alive at a median follow-up time of 54 mo (range: 5-108 mo). CONCLUSIONS: The EFS and OS of the present group were similar to that of the previous series which included children under 18 mo of age with neuroblastoma. Well known prognostic factors did not affect EFS and OS significantly; this may be related to the retrospective design of the present study and the small number of patients reviewed. High survival rate in infants with MYCN-amplified tumors suggests the difference in the biology of infant neuroblastoma.
OBJECTIVE: To determine outcome of neuroblastoma (NBL) in children under 18 mo of age who had been treated with national protocols. METHODS: The characteristics and treatment outcomes of 27 children were evaluated retrospectively. RESULTS: The event-free survival (EFS) at 60 and 108 mo were 84.7 % ± 7.7 and 72.6 % ± 7.7, respectively. The overall survival (OS) was 91.7 % ± 8 at 108 mo. The only significant risk factor for OS in children with neuroblastoma was the treatment response at the end of therapy (p = 0.001). "Wait and see" policy was applied to two infants with low risk NBL and one infant with stage 4S neuroblastoma and all 3 of these infants have been in remission at last followup. Four of the five patients with MYCN-amplified neuroblastoma were alive at a median follow-up time of 54 mo (range: 5-108 mo). CONCLUSIONS: The EFS and OS of the present group were similar to that of the previous series which included children under 18 mo of age with neuroblastoma. Well known prognostic factors did not affect EFS and OS significantly; this may be related to the retrospective design of the present study and the small number of patients reviewed. High survival rate in infants with MYCN-amplified tumors suggests the difference in the biology of infantneuroblastoma.
Authors: Rani E George; Wendy B London; Susan L Cohn; John M Maris; Cynthia Kretschmar; Lisa Diller; Garrett M Brodeur; Robert P Castleberry; A Thomas Look Journal: J Clin Oncol Date: 2005-08-22 Impact factor: 44.544
Authors: Mary Lou Schmidt; Ashutosh Lal; Robert C Seeger; John M Maris; Hiroyuki Shimada; Maura O'Leary; Robert B Gerbing; Katherine K Matthay Journal: J Clin Oncol Date: 2005-08-22 Impact factor: 44.544
Authors: H Rubie; O Hartmann; J Michon; D Frappaz; C Coze; P Chastagner; M C Baranzelli; D Plantaz; H Avet-Loiseau; J Bénard; O Delattre; M Favrot; M C Peyroulet; A Thyss; Y Perel; C Bergeron; B Courbon-Collet; J P Vannier; J Lemerle; D Sommelet Journal: J Clin Oncol Date: 1997-03 Impact factor: 44.544
Authors: G P Tonini; L Boni; A Pession; D Rogers; A Iolascon; G Basso; L Cordero di Montezemolo; F Casale; A Pession; P Perri; K Mazzocco; P Scaruffi; C Lo Cunsolo; N Marchese; C Milanaccio; M Conte; P Bruzzi; B De Bernardi Journal: J Clin Oncol Date: 1997-01 Impact factor: 44.544
Authors: Rochelle Bagatell; Maja Beck-Popovic; Wendy B London; Yang Zhang; Andrew D J Pearson; Katherine K Matthay; Tom Monclair; Peter F Ambros; Susan L Cohn Journal: J Clin Oncol Date: 2008-12-01 Impact factor: 44.544
Authors: Anna Rita Gigliotti; Andrea Di Cataldo; Stefania Sorrentino; Stefano Parodi; Antonino Rizzo; Piero Buffa; Claudio Granata; Angela Rita Sementa; Anna Maria Fagnani; Massimo Provenzi; Arcangelo Prete; Carmelita D'Ippolito; Anna Clerico; Aurora Castellano; Gian Paolo Tonini; Massimo Conte; Alberto Garaventa; Bruno De Bernardi Journal: Eur J Cancer Date: 2009-09-18 Impact factor: 9.162