BACKGROUND/ OBJECTIVES: While type II diabetes (DM) is a major cause of morbidity in the United States, limited data are available on the association between nut intake and incident DM. We sought to examine the association between nut consumption and the risk of DM. SUBJECTS/ METHODS: Prospective cohort of 20 224 male participants of the Physicians' Health Study I. Nut consumption was estimated using a 19-item brief food frequency questionnaire, and incident DM was ascertained through yearly follow-up questionnaires. Cox regression was used to estimate relative risks of DM. RESULTS: The average age of the study participants was 54.4+/-9.4 years (range: 40.7-87.1). During a mean follow-up of 19.2 years, 1828 cases of DM occurred. The crude incidence rates of DM were 4.82, 4.85, 4.92, 4.16, 4.29 and 3.32 cases per 1000 person-years for individuals reporting nut consumption of rarely/never, <1, 1, 2-4, 5-6 and 7+ servings per week, respectively. While nut consumption was associated with a lower risk of DM in a model adjusted for age (P for tend 0.017), such relation was attenuated on additional control for other confounders (multivariable adjusted hazard ratios (95% confidence interval) for DM were 1.0 (reference), 1.06 (0.93-1.20), 1.10 (0.95-1.26), 0.97 (0.82-1.14), 0.99 (0.76-1.30) and 0.87 (0.61-1.24) from the lowest to the highest category of nut consumption, respectively (P for trend 0.99). No statistically significant association between nut consumption and DM was found in either lean or overweight/obese participants. CONCLUSIONS: Our data do not show an association between nut consumption and incident DM in US male physicians.
RCT Entities:
BACKGROUND/ OBJECTIVES: While type II diabetes (DM) is a major cause of morbidity in the United States, limited data are available on the association between nut intake and incident DM. We sought to examine the association between nut consumption and the risk of DM. SUBJECTS/ METHODS: Prospective cohort of 20 224 male participants of the Physicians' Health Study I. Nut consumption was estimated using a 19-item brief food frequency questionnaire, and incident DM was ascertained through yearly follow-up questionnaires. Cox regression was used to estimate relative risks of DM. RESULTS: The average age of the study participants was 54.4+/-9.4 years (range: 40.7-87.1). During a mean follow-up of 19.2 years, 1828 cases of DM occurred. The crude incidence rates of DM were 4.82, 4.85, 4.92, 4.16, 4.29 and 3.32 cases per 1000 person-years for individuals reporting nut consumption of rarely/never, <1, 1, 2-4, 5-6 and 7+ servings per week, respectively. While nut consumption was associated with a lower risk of DM in a model adjusted for age (P for tend 0.017), such relation was attenuated on additional control for other confounders (multivariable adjusted hazard ratios (95% confidence interval) for DM were 1.0 (reference), 1.06 (0.93-1.20), 1.10 (0.95-1.26), 0.97 (0.82-1.14), 0.99 (0.76-1.30) and 0.87 (0.61-1.24) from the lowest to the highest category of nut consumption, respectively (P for trend 0.99). No statistically significant association between nut consumption and DM was found in either lean or overweight/obeseparticipants. CONCLUSIONS: Our data do not show an association between nut consumption and incident DM in US male physicians.
Authors: Linda C Tapsell; Lynda J Gillen; Craig S Patch; Marijka Batterham; Alice Owen; Marian Baré; Meredith Kennedy Journal: Diabetes Care Date: 2004-12 Impact factor: 19.112
Authors: W C Willett; L Sampson; M J Stampfer; B Rosner; C Bain; J Witschi; C H Hennekens; F E Speizer Journal: Am J Epidemiol Date: 1985-07 Impact factor: 4.897
Authors: S Salvini; D J Hunter; L Sampson; M J Stampfer; G A Colditz; B Rosner; W C Willett Journal: Int J Epidemiol Date: 1989-12 Impact factor: 7.196
Authors: Chisa Matsumoto; Andrew B Petrone; Howard D Sesso; J Michael Gaziano; Luc Djoussé Journal: Am J Clin Nutr Date: 2014-11-26 Impact factor: 7.045
Authors: Effie Viguiliouk; Cyril W C Kendall; Sonia Blanco Mejia; Adrian I Cozma; Vanessa Ha; Arash Mirrahimi; Viranda H Jayalath; Livia S A Augustin; Laura Chiavaroli; Lawrence A Leiter; Russell J de Souza; David J A Jenkins; John L Sievenpiper Journal: PLoS One Date: 2014-07-30 Impact factor: 3.240