Literature DB >> 19753348

Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrate antigen GM3.

Qianli Wang1, Jie Xue, Zhongwu Guo.   

Abstract

An efficient synthesis of a derivative of monophosphoryl lipid A suitable for coupling to various structures for the construction of glycoconjugate vaccines and its conjugation with an N-modified form of the tumor-associated antigen GM3 is presented.

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Year:  2009        PMID： 19753348      PMCID： PMC2877631          DOI： 10.1039/b907351e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  15 in total

Review 1.  Monophosphoryl lipid A (MPL) formulations for the next generation of vaccines.

Authors:  J R Baldridge; R T Crane
Journal:  Methods       Date:  1999-09       Impact factor: 3.608

Review 2.  Structure-function relationships of bacterial endotoxins. Contribution to microbial sepsis.

Authors:  D C Morrison; R Silverstein; M Luchi; A Shnyra
Journal:  Infect Dis Clin North Am       Date:  1999-06       Impact factor: 5.982

Review 3.  Toll receptors, CD14, and macrophage activation and deactivation by LPS.

Authors:  Marina A Dobrovolskaia; Stefanie N Vogel
Journal:  Microbes Infect       Date:  2002-07       Impact factor: 2.700

Review 4.  Taking toll: lipid A mimetics as adjuvants and immunomodulators.

Authors:  David H Persing; Rhea N Coler; Michael J Lacy; David A Johnson; Jory R Baldridge; Robert M Hershberg; Steven G Reed
Journal:  Trends Microbiol       Date:  2002       Impact factor: 17.079

5.  Synthesis of lipid A derivatives and their interactions with polymyxin B and polymyxin B nonapeptide.

Authors:  Ning Yin; Ryan L Marshall; Sannali Matheson; Paul B Savage
Journal:  J Am Chem Soc       Date:  2003-03-05       Impact factor: 15.419

Review 6.  Lipid A diversity and the innate host response to bacterial infection.

Authors:  R P Darveau
Journal:  Curr Opin Microbiol       Date:  1998-02       Impact factor: 7.934

Review 7.  Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant.

Authors:  C R Casella; T C Mitchell
Journal:  Cell Mol Life Sci       Date:  2008-10       Impact factor: 9.261

8.  Synthesis and biological evaluation of Rhizobium sin-1 lipid A derivatives.

Authors:  Alexei V Demchenko; Margreet A Wolfert; Balaji Santhanam; James N Moore; Geert-Jan Boons
Journal:  J Am Chem Soc       Date:  2003-05-21       Impact factor: 15.419

9.  Synthesis of Kdo-alpha-glycosides of lipid A derivatives.

Authors:  H Rembold; R R Schmidt
Journal:  Carbohydr Res       Date:  1993-08-17       Impact factor: 2.104

Review 10.  Bacterial endotoxin: molecular relationships of structure to activity and function.

Authors:  E T Rietschel; T Kirikae; F U Schade; U Mamat; G Schmidt; H Loppnow; A J Ulmer; U Zähringer; U Seydel; F Di Padova
Journal:  FASEB J       Date:  1994-02       Impact factor: 5.191
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  9 in total

1.  Combining synthetic carbohydrate vaccines with cancer cell glycoengineering for effective cancer immunotherapy.

Authors:  Lei Qiu; Xi Gong; Qianli Wang; Jie Li; Honggang Hu; Qiuye Wu; Junping Zhang; Zhongwu Guo
Journal:  Cancer Immunol Immunother       Date:  2012-04-27       Impact factor: 6.968

2.  Carbohydrate-monophosphoryl lipid a conjugates are fully synthetic self-adjuvanting cancer vaccines eliciting robust immune responses in the mouse.

Authors:  Qianli Wang; Zhifang Zhou; Shouchu Tang; Zhongwu Guo
Journal:  ACS Chem Biol       Date:  2011-11-01       Impact factor: 5.100

Review 3.  Progress in the synthesis and biological evaluation of lipid A and its derivatives.

Authors:  Jian Gao; Zhongwu Guo
Journal:  Med Res Rev       Date:  2017-06-16       Impact factor: 12.944

4.  Synthesis and evaluation of monophosphoryl lipid A derivatives as fully synthetic self-adjuvanting glycoconjugate cancer vaccine carriers.

Authors:  Zhifang Zhou; Mohabul Mondal; Guochao Liao; Zhongwu Guo
Journal:  Org Biomol Chem       Date:  2014-04-14       Impact factor: 3.876

5.  Fully Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines against Group C Meningitis.

Authors:  Guochao Liao; Zhifang Zhou; Sharad Suryawanshi; Mohabul A Mondal; Zhongwu Guo
Journal:  ACS Cent Sci       Date:  2016-04-04       Impact factor: 14.553

6.  A Fully Synthetic Self-Adjuvanting Globo H-Based Vaccine Elicited Strong T Cell-Mediated Antitumor Immunity.

Authors:  Zhifang Zhou; Guochao Liao; Satadru S Mandal; Sharad Suryawanshi; Zhongwu Guo
Journal:  Chem Sci       Date:  2015-09-22       Impact factor: 9.825

Review 7.  Aminosugar-based immunomodulator lipid A: synthetic approaches.

Authors:  Alla Zamyatina
Journal:  Beilstein J Org Chem       Date:  2018-01-04       Impact factor: 2.883

Review 8.  Recent Advances in Toll Like Receptor-Targeting Glycoconjugate Vaccines.

Authors:  Qingjiang Li; Zhongwu Guo
Journal:  Molecules       Date:  2018-06-29       Impact factor: 4.411

9.  Synthesis of monophosphorylated lipid A precursors using 2-naphthylmethyl ether as a protecting group.

Authors:  Jundi Xue; Ziyi Han; Gen Li; Khalisha A Emmanuel; Cynthia L McManus; Qiang Sui; Dongmian Ge; Qi Gao; Li Cai
Journal:  Beilstein J Org Chem       Date:  2020-08-10       Impact factor: 2.883
  9 in total

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