Literature DB >> 10525445

Monophosphoryl lipid A (MPL) formulations for the next generation of vaccines.

J R Baldridge1, R T Crane.   

Abstract

Many of the latest trends in vaccine development are dependent on immunological adjuvants that mediate and promote a wide variety of immune responses. One promising adjuvant candidate, monophosphoryl lipid A (MPL) immunostimulant, is being investigated with many of these new vaccine approaches in either preclinical or clinical trials. This is possible because different vehicle formulations can significantly influence the type of immunological response MPL promotes. Procedures are provided for formulating MPL in an aqueous vehicle or an oil-in-water emulsion. These two MPL formulations can be beneficial for most vaccine approaches being investigated today. Copyright 1999 Academic Press.

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Year:  1999        PMID： 10525445     DOI： 10.1006/meth.1999.0834

Source DB:  PubMed          Journal:  Methods        ISSN： 1046-2023            Impact factor:   3.608


  51 in total

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