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Literature DB >> 19736912

A magnetically triggered composite membrane for on-demand drug delivery.

Todd Hoare¹, Jesus Santamaria, Gerardo F Goya, Silvia Irusta, Debora Lin, Samantha Lau, Robert Padera, Robert Langer, Daniel S Kohane.

Abstract

Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve "on-demand" drug delivery upon the application of an oscillating magnetic field. On-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices. The total drug dose delivered was directly proportional to the duration of the "on" pulse. The membranes were noncytotoxic, were biocompatible, and retained their switchable flux properties after 45 days of subcutaneous implantation.

Entities: Chemical Disease Species

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Year: 2009 PMID： 19736912 PMCID： PMC2761986 DOI： 10.1021/nl9018935

Source DB: PubMed Journal: Nano Lett ISSN： 1530-6984 Impact factor: 11.189

21 in total

Review 1. Environment-sensitive hydrogels for drug delivery.

Authors: Y Qiu; K Park
Journal: Adv Drug Deliv Rev Date: 2001-12-31 Impact factor: 15.470

Review 2. Pulsatile drug release control using hydrogels.

Authors: Akihiko Kikuchi; Teruo Okano
Journal: Adv Drug Deliv Rev Date: 2002-01-17 Impact factor: 15.470

3. Multifunctionalized polymer microcapsules: novel tools for biological and pharmacological applications.

Authors: Gleb B Sukhorukov; Andrey L Rogach; Malgorzata Garstka; Sebastian Springer; Wolfgang J Parak; Almudena Muñoz-Javier; Oliver Kreft; Andre G Skirtach; Andrei S Susha; Yannic Ramaye; Raghavendra Palankar; Mathias Winterhalter
Journal: Small Date: 2007-06 Impact factor: 13.281

4. Controlled rupture of magnetic polyelectrolyte microcapsules for drug delivery.

Authors: Shang-Hsiu Hu; Chia-Hui Tsai; Chen-Fu Liao; Dean-Mo Liu; San-Yuan Chen
Journal: Langmuir Date: 2008-09-23 Impact factor: 3.882

5. Tensile testing of connective tissues.

Authors: P D Soden; I Kershaw
Journal: Med Biol Eng Date: 1974-07

6. Optimization of release from magnetically controlled polymeric drug release devices.

Authors: E R Edelman; R Langer
Journal: Biomaterials Date: 1993-07 Impact factor: 12.479

7. Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery.

Authors: S R Sershen; S L Westcott; N J Halas; J L West
Journal: J Biomed Mater Res Date: 2000-09-05

8. Drug-sensing hydrogels for the inducible release of biopharmaceuticals.

Authors: Martin Ehrbar; Ronald Schoenmakers; Erik H Christen; Martin Fussenegger; Wilfried Weber
Journal: Nat Mater Date: 2008-08-10 Impact factor: 43.841

9. Multi-pulse drug delivery from a resorbable polymeric microchip device.

Authors: Amy C Richards Grayson; Insung S Choi; Betty M Tyler; Paul P Wang; Henry Brem; Michael J Cima; Robert Langer
Journal: Nat Mater Date: 2003-11 Impact factor: 43.841

10. Swelling controlled zero order and sigmoidal drug release from thermo-responsive poly(N-isopropylacrylamide-co-butyl methacrylate) hydrogel.

Authors: Y Okuyama; R Yoshida; K Sakai; T Okano; Y Sakurai
Journal: J Biomater Sci Polym Ed Date: 1993 Impact factor: 3.517

63 in total

1. Polysaccharide-Based Nanoparticles for Two-Step Responsive Release of Antitumor Drug.

Authors: Hong-Guang Fu; Yong Chen; Qilin Yu; Yu Liu
Journal: ACS Med Chem Lett Date: 2020-05-18 Impact factor: 4.345

Review 2. Advances in Biomaterials for Drug Delivery.

Authors: Owen S Fenton; Katy N Olafson; Padmini S Pillai; Michael J Mitchell; Robert Langer
Journal: Adv Mater Date: 2018-05-07 Impact factor: 30.849

Review 3. Enabling individualized therapy through nanotechnology.

Authors: Jason H Sakamoto; Anne L van de Ven; Biana Godin; Elvin Blanco; Rita E Serda; Alessandro Grattoni; Arturas Ziemys; Ali Bouamrani; Tony Hu; Shivakumar I Ranganathan; Enrica De Rosa; Jonathan O Martinez; Christine A Smid; Rachel M Buchanan; Sei-Young Lee; Srimeenakshi Srinivasan; Matthew Landry; Anne Meyn; Ennio Tasciotti; Xuewu Liu; Paolo Decuzzi; Mauro Ferrari
Journal: Pharmacol Res Date: 2010-01-05 Impact factor: 7.658

A magnetically triggered composite membrane for on-demand drug delivery.

Review 1. Environment-sensitive hydrogels for drug delivery.

Review 2. Pulsatile drug release control using hydrogels.

3. Multifunctionalized polymer microcapsules: novel tools for biological and pharmacological applications.

4. Controlled rupture of magnetic polyelectrolyte microcapsules for drug delivery.

5. Tensile testing of connective tissues.

6. Optimization of release from magnetically controlled polymeric drug release devices.

7. Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery.

8. Drug-sensing hydrogels for the inducible release of biopharmaceuticals.

9. Multi-pulse drug delivery from a resorbable polymeric microchip device.

10. Swelling controlled zero order and sigmoidal drug release from thermo-responsive poly(N-isopropylacrylamide-co-butyl methacrylate) hydrogel.

1. Polysaccharide-Based Nanoparticles for Two-Step Responsive Release of Antitumor Drug.

Review 2. Advances in Biomaterials for Drug Delivery.

Review 3. Enabling individualized therapy through nanotechnology.

Review 4. Extracellularly activatable nanocarriers for drug delivery to tumors.

5. Switchable Release of Entrapped Nanoparticles from Alginate Hydrogels.

6. A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery.

7. Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane.

8. Programmable and on-demand drug release using electrical stimulation.

Review 9. Phototriggered Drug Delivery Using Inorganic Nanomaterials.

10. Sequential release of nanoparticle payloads from ultrasonically burstable capsules.