Literature DB >> 19733480

Stem cells, stress, metabolism and cancer: a drama in two Octs.

Jinsuk Kang1, Arvind Shakya, Dean Tantin.   

Abstract

It is a classic story of two related transcription factors. Oct4 is a potent regulator of pluripotency during early mammalian embryonic development, and is notable for its ability to convert adult somatic cells to pluripotency. The widely expressed Oct1 protein shares significant homology with Oct4, binds to the same sequences, regulates common target genes, and shares common modes of upstream regulation, including the ability to respond to cellular stress. Both proteins are also associated with malignancy, yet Oct1 cannot substitute for Oct4 in the generation of pluripotency. The molecular underpinnings of these phenomena are emerging, as are the consequences for adult stem cells and cancer, and thereby hangs a tale.

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Year:  2009        PMID： 19733480     DOI： 10.1016/j.tibs.2009.06.003

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  59 in total

1.  Impact of protein/protein interactions on global intermolecular translocation rates of the transcription factors Sox2 and Oct1 between DNA cognate sites analyzed by z-exchange NMR spectroscopy.

Authors:  Yuki Takayama; G Marius Clore
Journal:  J Biol Chem       Date:  2012-06-20       Impact factor: 5.157

2.  Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states.

Authors:  Arvind Shakya; Jinsuk Kang; Jeffrey Chumley; Matthew A Williams; Dean Tantin
Journal:  J Biol Chem       Date:  2010-11-04       Impact factor: 5.157

3.  Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor.

Authors:  Khairul I Ansari; Daisuke Ogawa; Arun K Rooj; Sean E Lawler; Anna M Krichevsky; Mark D Johnson; E Antonio Chiocca; Agnieszka Bronisz; Jakub Godlewski
Journal:  Cell Rep       Date:  2015-04-30       Impact factor: 9.423

4.  Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer.

Authors:  Zhen Li; Jin Su; Mingming Sun; Jiaqi Song; Huanran Sun; Jun Fan; Guo Chen; Changliang Shan; Qi Qi; Shuai Zhang
Journal:  Mol Cell Biochem       Date:  2021-05-10       Impact factor: 3.396

5.  Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency.

Authors:  Amanda R Robinson; Swee Sen Kwek; Stacy R Hagemeier; Coral K Wille; Shannon C Kenney
Journal:  J Virol       Date:  2011-06-22       Impact factor: 5.103

6.  [Expressions of OCT4, Notch1 and DLL4 and their clinical implications in epithelial ovarian cancer].

Authors:  Lan Yu; Yun-Jie Jiao; Lei Zhou; Wen-Qing Song; Shi-Wu Wu; Dan-Na Wang
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2016-04-20

Review 7.  Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate.

Authors:  Victoria A Rafalski; Elena Mancini; Anne Brunet
Journal:  J Cell Sci       Date:  2012-12-01       Impact factor: 5.285

8.  Involvement of transcription factor Oct-1 in the regulation of JAK-STAT signaling pathway in cells of Burkitt lymphoma.

Authors:  E V Pankratova; A G Stepchenko; I D Krylova; T N Portseva; S G Georgieva
Journal:  Dokl Biochem Biophys       Date:  2016-07-15       Impact factor: 0.788

9.  Pluripotency transcription factor Oct4 mediates stepwise nucleosome demethylation and depletion.

Authors:  Arvind Shakya; Catherine Callister; Alon Goren; Nir Yosef; Neha Garg; Vahid Khoddami; David Nix; Aviv Regev; Dean Tantin
Journal:  Mol Cell Biol       Date:  2015-01-12       Impact factor: 4.272

10.  Regulation of Oct1/Pou2f1 transcription activity by O-GlcNAcylation.

Authors:  Jinsuk Kang; Zuolian Shen; Jae-Min Lim; Hiroshi Handa; Lance Wells; Dean Tantin
Journal:  FASEB J       Date:  2013-04-11       Impact factor: 5.191
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