Literature DB >> 27417729

Involvement of transcription factor Oct-1 in the regulation of JAK-STAT signaling pathway in cells of Burkitt lymphoma.

E V Pankratova1, A G Stepchenko2, I D Krylova3, T N Portseva2, S G Georgieva2.   

Abstract

We studied the role of transcription factor Oct-1 in the regulation of expression of genes of the JAK-STAT signaling pathway in the Namalwa Burkitt's lymphoma cell line. Overexpression of Oct-1 isoforms (Oct-1A, Oct-1L, and Oct-1X) causes a decrease in the activity of four genes involved in the JAK-STAT signaling pathway-IFNAR2, STAT1, STAT2, and STAT4. As a result of our research, it was found that genes STAT2 and STAT4 are direct targets for Oct-1 protein.

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Year:  2016        PMID： 27417729     DOI： 10.1134/S1607672916030200

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  15 in total

1.  Cloning, genomic organization, expression, and effect on beta-casein promoter activity of a novel isoform of the mouse Oct-1 transcription factor.

Authors:  Feng-Qi Zhao; Yucai Zheng; Bing Dong; Takami Oka
Journal:  Gene       Date:  2004-02-04       Impact factor: 3.688

Review 2.  [Oct-1 transcription factor--plasticity and polyfunctionality].

Authors:  E V Sytina; E V Pankratova
Journal:  Mol Biol (Mosk)       Date:  2003 Sep-Oct

3.  The nucleotide sequence of mouse OCT-1 cDNA.

Authors:  A G Stepchenko
Journal:  Nucleic Acids Res       Date:  1992-03-25       Impact factor: 16.971

4.  New alternative promoter in regulation of the Oct-1 human gene transcription.

Authors:  T N Portseva; I D Krylova; S G Georgieva; A G Stepchenko; E V Pankratova
Journal:  Dokl Biochem Biophys       Date:  2013-05-09       Impact factor: 0.788

5.  [The new isoform of Oct-1 transcription factor is transcribed from alternative promoter].

Authors:  I D Krylova; T N Portseva; S G Georgieva; A G Stepchenko; E V Pankratova
Journal:  Mol Biol (Mosk)       Date:  2013 Jul-Aug

6.  The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

Authors:  W Herr; R A Sturm; R G Clerc; L M Corcoran; D Baltimore; P A Sharp; H A Ingraham; M G Rosenfeld; M Finney; G Ruvkun
Journal:  Genes Dev       Date:  1988-12       Impact factor: 11.361

Review 7.  Targeting the JAK-STAT pathway in lymphoma: a focus on pacritinib.

Authors:  Enrico Derenzini; Anas Younes
Journal:  Expert Opin Investig Drugs       Date:  2013-02-26       Impact factor: 6.206

Review 8.  JAK/STAT signaling in hematological malignancies.

Authors:  W Vainchenker; S N Constantinescu
Journal:  Oncogene       Date:  2012-08-06       Impact factor: 9.867

9.  The alternative protein isoform NK2B, encoded by the vnd/NK-2 proneural gene, directly activates transcription and is expressed following the start of cells differentiation.

Authors:  Alexander G Stepchenko; Elizaveta V Pankratova; Semen A Doronin; Pavel V Gulag; Sofia G Georgieva
Journal:  Nucleic Acids Res       Date:  2011-03-21       Impact factor: 16.971

10.  High expression of octamer transcription factor 1 in cervical cancer.

Authors:  Songshu Xiao; Shan Liao; Yanhong Zhou; Bin Jiang; Yueran Li; Min Xue
Journal:  Oncol Lett       Date:  2014-04-02       Impact factor: 2.967
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  1 in total

1.  Association Between the Methylation Statuses at CpG Sites in the Promoter Region of the SLCO1B3, RNA Expression and Color Change in Blue Eggshells in Lushi Chickens.

Authors:  Zhuanjian Li; Tuanhui Ren; Wenya Li; Yu Zhou; Ruili Han; Hong Li; Ruirui Jiang; Fengbin Yan; Guirong Sun; Xiaojun Liu; Yadong Tian; Xiangtao Kang
Journal:  Front Genet       Date:  2019-02-26       Impact factor: 4.599
  1 in total

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