| Literature DB >> 19731553 |
Eleni Roussa1, Oliver von Bohlen und Halbach, Kerstin Krieglstein.
Abstract
ransforming growth factor betas (TGF-betas) are multifunctional cytokines with widespread distribution.In the nervous system the biological effects of TGF-beta cover regulation of proliferation, migration, differentiation, survival and death. Specifically, the effects of TGF-(3 on mesencephalic DAergic neurons extend from induction and specification of the dopaminergic phenotype via promotion of survival to neuroprotection in animal models of parkinsonism. Experimental in vitro and in vivo models have contributed to a better understanding of the putative mechanisms underlying the effects of TGF-beta on DAergic neurons and unravelled synergisms between members of the TGF-beta superfamily. In this chapter, we will review the literature available with focus on TGF-beta proper and glial cell-line-derived neurotrophic factor (GDNF).Entities:
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Year: 2009 PMID： 19731553 DOI： 10.1007/978-1-4419-0322-8_8
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622