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Literature DB >> 28130363

TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function.

Abstract

Signaling by the transforming growth factor β (TGF-β) family is necessary for proper neural development and function throughout life. Sequential waves of activation, inhibition, and reactivation of TGF-β family members regulate numerous elements of the nervous system from the earliest stages of embryogenesis through adulthood. This review discusses the expression, regulation, and function of TGF-β family members in the central nervous system at various developmental stages, beginning with induction and patterning of the nervous system to their importance in the adult as modulators of inflammatory response and involvement in degenerative diseases.

Entities: Disease Gene

Mesh：

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Year: 2017 PMID： 28130363 PMCID： PMC5538418 DOI： 10.1101/cshperspect.a022244

Source DB: PubMed Journal: Cold Spring Harb Perspect Biol ISSN： 1943-0264 Impact factor: 10.005

296 in total

1. Generation of cerebellar granule neurons in vivo by transplantation of BMP-treated neural progenitor cells.

Authors: J Alder; K J Lee; T M Jessell; M E Hatten
Journal: Nat Neurosci Date: 1999-06 Impact factor: 24.884

2. Multiple roles of bone morphogenetic protein signaling in the regulation of cortical cell number and phenotype.

Authors: P C Mabie; M F Mehler; J A Kessler
Journal: J Neurosci Date: 1999-08-15 Impact factor: 6.167

3. The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice.

Authors: J Song; S P Oh; H Schrewe; M Nomura; H Lei; M Okano; T Gridley; E Li
Journal: Dev Biol Date: 1999-09-01 Impact factor: 3.582

4. BMPs inhibit neurogenesis by a mechanism involving degradation of a transcription factor.

Authors: J Shou; P C Rim; A L Calof
Journal: Nat Neurosci Date: 1999-04 Impact factor: 24.884

5. Transforming growth factor beta1 (TGFbeta1) mRNA level correlates with magnetic resonance imaging disease activity in multiple sclerosis patients.

Authors: A Bertolotto; M Capobianco; S Malucchi; E Manzardo; L Audano; M Bergui; G B Bradac; R Mutani
Journal: Neurosci Lett Date: 1999-03-19 Impact factor: 3.046

6. Bone morphogenetic protein-2 promotes survival and differentiation of striatal GABAergic neurons in the absence of glial cell proliferation.

Authors: A Hattori; M Katayama; S Iwasaki; K Ishii; M Tsujimoto; M Kohno
Journal: J Neurochem Date: 1999-06 Impact factor: 5.372

7. Expression of growth/differentiation factor 11, a new member of the BMP/TGFbeta superfamily during mouse embryogenesis.

Authors: M Nakashima; T Toyono; A Akamine; A Joyner
Journal: Mech Dev Date: 1999-02 Impact factor: 1.882

8. Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup.

Authors: M J Solloway; E J Robertson
Journal: Development Date: 1999-04 Impact factor: 6.868

9. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals.

Authors: S Piccolo; E Agius; L Leyns; S Bhattacharyya; H Grunz; T Bouwmeester; E M De Robertis
Journal: Nature Date: 1999-02-25 Impact factor: 49.962

10. Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord.

Authors: F Müller; B Chang; S Albert; N Fischer; L Tora; U Strähle
Journal: Development Date: 1999-05 Impact factor: 6.868

38 in total

1. Homozygous stop-gain variant in LRRC32, encoding a TGFβ receptor, associated with cleft palate, proliferative retinopathy, and developmental delay.

Authors: Tamar Harel; Ephrat Levy-Lahad; Muhannad Daana; Hadas Mechoulam; Smadar Horowitz-Cederboim; Michal Gur; Vardiella Meiner; Orly Elpeleg
Journal: Eur J Hum Genet Date: 2019-04-11 Impact factor: 4.246

Review 2. The role of TGF-β superfamily signaling in neurological disorders.

Authors: Risa Kashima; Akiko Hata
Journal: Acta Biochim Biophys Sin (Shanghai) Date: 2018-01-01 Impact factor: 3.848

3. [Inhibition of TGF-β promotes functional recovery of spinal cord injury in mice by reducing fibronectin deposition].

Authors: X Li; D Pan
Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2021-11-20

Review 4. Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential.

Authors: Ying Cao
Journal: Stem Cell Rev Rep Date: 2021-10-29 Impact factor: 5.739

Review 5. TGF-β as a Key Modulator of Astrocyte Reactivity: Disease Relevance and Therapeutic Implications.

Authors: Jian Luo
Journal: Biomedicines Date: 2022-05-23

6. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds.

Authors: Shayna T J Bradford; Egon J Ranghini; Edward Grimley; Pil H Lee; Gregory R Dressler
Journal: J Biol Chem Date: 2019-01-02 Impact factor: 5.157

7. Nanofountain Probe Electroporation Enables Versatile Single-Cell Intracellular Delivery and Investigation of Postpulse Electropore Dynamics.

Authors: Samba Shiva Prasad Nathamgari; Nibir Pathak; Vincent Lemaitre; Prithvijit Mukherjee; Joseph J Muldoon; Chian-Yu Peng; Tammy McGuire; Joshua N Leonard; John A Kessler; Horacio Dante Espinosa
Journal: Small Date: 2020-10-02 Impact factor: 13.281

8. TGFβ and Wnt Signaling Pathways Cooperatively Enhance Early Dopaminergic Differentiation of the Unrestricted Somatic Stem Cells.

Authors: Azimeh Akhlaghpour; Azita Parvaneh Tafreshi; Eleni Roussa; Claude Bernard; Bahman Zeynali
Journal: J Mol Neurosci Date: 2020-02-10 Impact factor: 3.444

Review 9. Tissue mechanics, an important regulator of development and disease.

Authors: Nadia M E Ayad; Shelly Kaushik; Valerie M Weaver
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2019-07-01 Impact factor: 6.237

10. A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation.

Authors: Noah Goshi; Rhianna K Morgan; Pamela J Lein; Erkin Seker
Journal: J Neuroinflammation Date: 2020-05-11 Impact factor: 8.322