Literature DB >> 19723760

Regulating the regulator: an RNA decoy acts as an OFF switch for the regulation of an sRNA.

Pierre Mandin1, Susan Gottesman.   

Abstract

Many bacterial small regulatory RNAs (sRNAs) pair with mRNA targets, stimulating or inhibiting mRNA stability and/or translation. Regulation of these sRNAs is usually due to tight transcriptional regulation of synthesis.In this issue of Genes & Development and a related paper in Molecular Microbiology, Figueroa-Bossi and colleagues (pp. 2004-2015) and Overgaard and colleagues report a novel regulatory mechanism in which induction of a competing mRNA acts to titrate away the sRNA, allowing expression of an otherwise strongly inhibited target gene.

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Year:  2009        PMID： 19723760      PMCID： PMC2751972          DOI： 10.1101/gad.1846609

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  21 in total

1.  A conserved small RNA promotes silencing of the outer membrane protein YbfM.

Authors:  Anders Aamann Rasmussen; Jesper Johansen; Jesper S Nielsen; Martin Overgaard; Birgitte Kallipolitis; Poul Valentin-Hansen
Journal:  Mol Microbiol       Date:  2009-05       Impact factor: 3.501

2.  Switching off small RNA regulation with trap-mRNA.

Authors:  Martin Overgaard; Jesper Johansen; Jakob Møller-Jensen; Poul Valentin-Hansen
Journal:  Mol Microbiol       Date:  2009-08-13       Impact factor: 3.501

Review 3.  Origins and Mechanisms of miRNAs and siRNAs.

Authors:  Richard W Carthew; Erik J Sontheimer
Journal:  Cell       Date:  2009-02-20       Impact factor: 41.582

Review 4.  Regulatory RNAs in bacteria.

Authors:  Lauren S Waters; Gisela Storz
Journal:  Cell       Date:  2009-02-20       Impact factor: 41.582

Review 5.  Noncoding RNA control of the making and breaking of sugars.

Authors:  Boris Görke; Jörg Vogel
Journal:  Genes Dev       Date:  2008-11-01       Impact factor: 11.361

6.  Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target.

Authors:  Nara Figueroa-Bossi; Martina Valentini; Laurette Malleret; Francesca Fiorini; Lionello Bossi
Journal:  Genes Dev       Date:  2009-07-28       Impact factor: 11.361

7.  A genetic approach for finding small RNAs regulators of genes of interest identifies RybC as regulating the DpiA/DpiB two-component system.

Authors:  Pierre Mandin; Susan Gottesman
Journal:  Mol Microbiol       Date:  2009-05       Impact factor: 3.501

8.  nhl-2 Modulates microRNA activity in Caenorhabditis elegans.

Authors:  Christopher M Hammell; Isabella Lubin; Peter R Boag; T Keith Blackwell; Victor Ambros
Journal:  Cell       Date:  2009-03-06       Impact factor: 41.582

Review 9.  Many roads to maturity: microRNA biogenesis pathways and their regulation.

Authors:  Julia Winter; Stephanie Jung; Sarina Keller; Richard I Gregory; Sven Diederichs
Journal:  Nat Cell Biol       Date:  2009-03       Impact factor: 28.824

10.  Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli.

Authors:  Eric Massé; Freddy E Escorcia; Susan Gottesman
Journal:  Genes Dev       Date:  2003-09-15       Impact factor: 12.890
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  9 in total

1.  A novel CsrA titration mechanism regulates fimbrial gene expression in Salmonella typhimurium.

Authors:  Torsten Sterzenbach; Kim T Nguyen; Sean-Paul Nuccio; Maria G Winter; Christopher A Vakulskas; Steven Clegg; Tony Romeo; Andreas J Bäumler
Journal:  EMBO J       Date:  2013-09-20       Impact factor: 11.598

Review 2.  Emerging roles for natural microRNA sponges.

Authors:  Margaret S Ebert; Phillip A Sharp
Journal:  Curr Biol       Date:  2010-10-12       Impact factor: 10.834

3.  PhoP induces RyjB expression under acid stress in Escherichia coli.

Authors:  Namra Siddiqui; Amit Kumar Gupta; Tanmay Dutta
Journal:  J Biochem       Date:  2022-03-03       Impact factor: 3.241

4.  C-terminal domain of the RNA chaperone Hfq drives sRNA competition and release of target RNA.

Authors:  Andrew Santiago-Frangos; Kumari Kavita; Daniel J Schu; Susan Gottesman; Sarah A Woodson
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-28       Impact factor: 11.205

5.  Structural insights into the dynamics and function of the C-terminus of the E. coli RNA chaperone Hfq.

Authors:  Mads Beich-Frandsen; Branislav Vecerek; Petr V Konarev; Björn Sjöblom; Karin Kloiber; Hermann Hämmerle; Lukas Rajkowitsch; Andrew J Miles; Georg Kontaxis; B A Wallace; Dimitri I Svergun; Robert Konrat; Udo Bläsi; Kristina Djinovic-Carugo
Journal:  Nucleic Acids Res       Date:  2011-02-17       Impact factor: 16.971

6.  Cross talk between ABC transporter mRNAs via a target mRNA-derived sponge of the GcvB small RNA.

Authors:  Masatoshi Miyakoshi; Yanjie Chao; Jörg Vogel
Journal:  EMBO J       Date:  2015-01-28       Impact factor: 11.598

Review 7.  Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation.

Authors:  Reena V Kartha; Subbaya Subramanian
Journal:  Front Genet       Date:  2014-01-30       Impact factor: 4.599

Review 8.  Small RNA functions in carbon metabolism and virulence of enteric pathogens.

Authors:  Kai Papenfort; Jörg Vogel
Journal:  Front Cell Infect Microbiol       Date:  2014-07-15       Impact factor: 5.293

9.  SpoVG Is a Conserved RNA-Binding Protein That Regulates Listeria monocytogenes Lysozyme Resistance, Virulence, and Swarming Motility.

Authors:  Thomas P Burke; Daniel A Portnoy
Journal:  MBio       Date:  2016-04-05       Impact factor: 7.867
  9 in total

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