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Literature DB >> 19721884

The Elmo family forms an ancient group of actin-regulating proteins.

Joseph A Brzostowski¹, Petra Fey, Jianshe Yan, Nilgun Isik, Tian Jin.

Abstract

The Elmo protein family members are important mediators of small G protein activity, regulating actin-mediated processes such as chemotaxis and engulfment. Until recently,1 Elmo function has not been explored in professional phagocytes such as Dictyostelium discoideum. We discuss the significance of this family with respect to pathways that regulate Rac signaling, we present a comparison of Elmo proteins between representative taxa, and discuss our findings on ElmoA, one of six Elmo proteins found in D. discoideum.

Entities: Species

Keywords: Dictyostelium; Elmo; TIRFM; actin; chemotaxis; myosin; small G-protein

Year: 2009 PMID： 19721884 PMCID： PMC2734041 DOI： 10.4161/cib.2.4.8549

Source DB: PubMed Journal: Commun Integr Biol ISSN： 1942-0889

24 in total

1. Visualizing large hierarchical clusters in hyperbolic space.

Authors: J Bingham; S Sudarsanam
Journal: Bioinformatics Date: 2000-07 Impact factor: 6.937

2. Cell motility and SCAR localisation in axenically growing Dictyostelium cells.

Authors: Alice Y Pollitt; Simone L Blagg; Neysi Ibarra; Robert H Insall
Journal: Eur J Cell Biol Date: 2006-07-05 Impact factor: 4.492

3. Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions.

Authors: Natalie Andrew; Robert H Insall
Journal: Nat Cell Biol Date: 2007-01-14 Impact factor: 28.824

Review 4. Chemotaxis in Dictyostelium: how to walk straight using parallel pathways.

Authors: Robert Insall; Natalie Andrew
Journal: Curr Opin Microbiol Date: 2007-11-26 Impact factor: 7.934

Review 5. GEF what? Dock180 and related proteins help Rac to polarize cells in new ways.

Authors: Jean-François Côté; Kristiina Vuori
Journal: Trends Cell Biol Date: 2007-08-31 Impact factor: 20.808

Review 6. How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum.

Authors: Tian Jin; Xuehua Xu; Jun Fang; Nilgun Isik; Jianshe Yan; Joseph A Brzostowski; Dale Hereld
Journal: Immunol Res Date: 2009 Impact factor: 2.829

Review 7. The engulfment process of programmed cell death in caenorhabditis elegans.

Authors: Peter W Reddien; H Robert Horvitz
Journal: Annu Rev Cell Dev Biol Date: 2004 Impact factor: 13.827

8. PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium.

Authors: Simone L Blagg; Michael Stewart; Christine Sambles; Robert H Insall
Journal: Curr Biol Date: 2003-09-02 Impact factor: 10.834

9. Abi1 is essential for the formation and activation of a WAVE2 signalling complex.

Authors: Metello Innocenti; Adriana Zucconi; Andrea Disanza; Emanuela Frittoli; Liliana B Areces; Anika Steffen; Theresia E B Stradal; Pier Paolo Di Fiore; Marie-France Carlier; Giorgio Scita
Journal: Nat Cell Biol Date: 2004-03-28 Impact factor: 28.824

10. An actin-based wave generator organizes cell motility.

Authors: Orion D Weiner; William A Marganski; Lani F Wu; Steven J Altschuler; Marc W Kirschner
Journal: PLoS Biol Date: 2007-09 Impact factor: 8.029

12 in total

1. Opening up on ELMO regulation: New insights into the control of Rac signaling by the DOCK180/ELMO complex.

Authors: Manishha Patel; Ariane Pelletier; Jean-François Côté
Journal: Small GTPases Date: 2011-09-01

2. ELMO domains, evolutionary and functional characterization of a novel GTPase-activating protein (GAP) domain for Arf protein family GTPases.

Authors: Michael P East; J Bradford Bowzard; Joel B Dacks; Richard A Kahn
Journal: J Biol Chem Date: 2012-09-26 Impact factor: 5.157

3. A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis.

Authors: Jianshe Yan; Vassil Mihaylov; Xuehua Xu; Joseph A Brzostowski; Hongyan Li; Lunhua Liu; Timothy D Veenstra; Carole A Parent; Tian Jin
Journal: Dev Cell Date: 2012-01-17 Impact factor: 12.270

4. A proteomics analysis of the ovarian development in females of Haemaphysalis longicornis.

Authors: Minjing Wang; Yuhong Hu; Mengxue Li; Qianqian Xu; Xiaoli Zhang; Xiaoshuang Wang; Xiaomin Xue; Qi Xiao; Jingze Liu; Hui Wang
Journal: Exp Appl Acarol Date: 2020-01-09 Impact factor: 2.132

5. A barley Engulfment and Motility domain containing protein modulates Rho GTPase activating protein HvMAGAP1 function in the barley powdery mildew interaction.

Authors: Caroline Hoefle; Ralph Hückelhoven
Journal: Plant Mol Biol Date: 2013-10-20 Impact factor: 4.076

6. Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia.

Authors: Kenneth R Johnson; Chantal M Longo-Guess; Leona H Gagnon
Journal: PLoS One Date: 2012-04-27 Impact factor: 3.240

10. Diaphanous homolog 3 (Diap3) overexpression causes progressive hearing loss and inner hair cell defects in a transgenic mouse model of human deafness.

Authors: Cynthia J Schoen; Margit Burmeister; Marci M Lesperance
Journal: PLoS One Date: 2013-02-18 Impact factor: 3.240