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Literature DB >> 19715272

Intelligent medical diagnostics via molecular logic.

Abstract

In this communication, we describe the integration of microarray sensor technology with logic capability for screening combinations of proteins and DNA in a biological sample. In this system, we have demonstrated the use of a single platform amenable to both protein detection and protein-DNA detection using molecular logic gates. The pattern of protein and DNA inputs results in fluorescence outputs according to a truth table for AND and INHIBIT gates, thereby demonstrating the feasibility of performing medical diagnostics using a logic gate design. One possible application of this technique would be direct screening of various medical conditions that are dependent on combinations of diagnostic markers.

Entities: Chemical Disease Species

Mesh：

Substances：
Proteins
DNA

Year: 2009 PMID： 19715272 PMCID： PMC2750850 DOI： 10.1021/ja905125b

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

35 in total

1. Construction of a genetic toggle switch in Escherichia coli.

Authors: T S Gardner; C R Cantor; J J Collins
Journal: Nature Date: 2000-01-20 Impact factor: 49.962

2. Reprogramming control of an allosteric signaling switch through modular recombination.

Authors: John E Dueber; Brian J Yeh; Kayam Chak; Wendell A Lim
Journal: Science Date: 2003-09-26 Impact factor: 47.728

3. Parallel molecular computations of pairwise exclusive-or (XOR) using DNA "string tile" self-assembly.

Authors: Hao Yan; Liping Feng; Thomas H LaBean; John H Reif
Journal: J Am Chem Soc Date: 2003-11-26 Impact factor: 15.419

4. Boolean logic functions of a synthetic peptide network.

Authors: Gonen Ashkenasy; M Reza Ghadiri
Journal: J Am Chem Soc Date: 2004-09-15 Impact factor: 15.419

5. Semibiological molecular machine with an implemented "AND" logic gate for regulation of protein folding.

Authors: Shinichi Muramatsu; Kazushi Kinbara; Hideki Taguchi; Noriyuki Ishii; Takuzo Aida
Journal: J Am Chem Soc Date: 2006-03-22 Impact factor: 15.419

6. Biocomputing security system: concatenated enzyme-based logic gates operating as a biomolecular keypad lock.

Authors: Guinevere Strack; Maryna Ornatska; Marcos Pita; Evgeny Katz
Journal: J Am Chem Soc Date: 2008-03-06 Impact factor: 15.419

7. DNA solution of the maximal clique problem.

Authors: Q Ouyang; P D Kaplan; S Liu; A Libchaber
Journal: Science Date: 1997-10-17 Impact factor: 47.728

8. Molecular computation of solutions to combinatorial problems.

Authors: L M Adleman
Journal: Science Date: 1994-11-11 Impact factor: 47.728

Review 9. Engineered gene circuits.

Authors: Jeff Hasty; David McMillen; J J Collins
Journal: Nature Date: 2002-11-14 Impact factor: 49.962

10. A visual dual-aptamer logic gate for sensitive discrimination of prion diseases-associated isoform with reusable magnetic microparticles and fluorescence quantum dots.

Authors: Sai Jin Xiao; Ping Ping Hu; Li Qiang Chen; Shu Jun Zhen; Li Peng; Yuan Fang Li; Cheng Zhi Huang
Journal: PLoS One Date: 2013-02-05 Impact factor: 3.240

Intelligent medical diagnostics via molecular logic.

1. Construction of a genetic toggle switch in Escherichia coli.

2. Reprogramming control of an allosteric signaling switch through modular recombination.

3. Parallel molecular computations of pairwise exclusive-or (XOR) using DNA "string tile" self-assembly.

4. Boolean logic functions of a synthetic peptide network.

5. Semibiological molecular machine with an implemented "AND" logic gate for regulation of protein folding.

6. Biocomputing security system: concatenated enzyme-based logic gates operating as a biomolecular keypad lock.

7. DNA solution of the maximal clique problem.

8. Molecular computation of solutions to combinatorial problems.

Review 9. Engineered gene circuits.

10. IgE antibodies to bacteria in patients with bronchial asthma.

1. Biomolecular computing: learning through play.

2. A highly parallel microfluidic droplet method enabling single-molecule counting for digital enzyme detection.

3. Measuring binding of protein to gel-bound ligands using magnetic levitation.

4. Label-free, dual-analyte electrochemical biosensors: a new class of molecular-electronic logic gates.

5. Bridging the Two Worlds: A Universal Interface between Enzymatic and DNA Computing Systems.

6. Particles and microfluidics merged: perspectives of highly sensitive diagnostic detection.

7. All-photonic multifunctional molecular logic device.

8. OFF-ON-OFF fluorescence switch with T-latch function.

9. An all-photonic molecule-based D flip-flop.

10. A visual dual-aptamer logic gate for sensitive discrimination of prion diseases-associated isoform with reusable magnetic microparticles and fluorescence quantum dots.