Literature DB >> 19713959

APT drug R&D: the right active ingredient in the right presentation for the right therapeutic use.

David Cavalla1.   

Abstract

Drug repurposing, in which an established active pharmaceutical ingredient is applied in a new way - for example, for a new indication, and often combined with an alternative method of presentation, such as a novel delivery route - is an evolving strategy for pharmaceutical R&D. This article discusses examples of the success of this strategy, and presents an analysis of sales of US pharmaceutical products that suggests that this low-risk approach to new product development retains substantial commercial value.

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Year:  2009        PMID: 19713959     DOI: 10.1038/nrd2981

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


  9 in total

1.  Returns on research and development for 1990s new drug introductions.

Authors:  Henry Grabowski; John Vernon; Joseph A DiMasi
Journal:  Pharmacoeconomics       Date:  2002       Impact factor: 4.981

2.  Therapeutic switching: a new strategic approach to enhance R&D productivity.

Authors:  David Cavalla
Journal:  IDrugs       Date:  2005-11

Review 3.  Pharmaceutical R&D in the spotlight: why is there still unmet medical need?

Authors:  Esther F Schmid; Dennis A Smith
Journal:  Drug Discov Today       Date:  2007-10-23       Impact factor: 7.851

4.  Tapping the potential of fixed-dose combinations.

Authors:  Tara M Herrick; Ryan P Million
Journal:  Nat Rev Drug Discov       Date:  2007-07       Impact factor: 84.694

5.  Drug target identification using side-effect similarity.

Authors:  Monica Campillos; Michael Kuhn; Anne-Claude Gavin; Lars Juhl Jensen; Peer Bork
Journal:  Science       Date:  2008-07-11       Impact factor: 47.728

Review 6.  What drives success for specialty pharmaceuticals?

Authors:  Mark Gudiksen; Edd Fleming; Laura Furstenthal; Philip Ma
Journal:  Nat Rev Drug Discov       Date:  2008-06-06       Impact factor: 84.694

7.  Big interest in heavy drugs.

Authors:  Katharine Sanderson
Journal:  Nature       Date:  2009-03-19       Impact factor: 49.962

8.  Mixed results for disease-modification strategies for Alzheimer's disease.

Authors:  Alisa Opar
Journal:  Nat Rev Drug Discov       Date:  2008-09       Impact factor: 84.694

Review 9.  Transdermal drug delivery.

Authors:  Mark R Prausnitz; Robert Langer
Journal:  Nat Biotechnol       Date:  2008-11       Impact factor: 54.908

  9 in total
  4 in total

Review 1.  Using human experience to identify drug repurposing opportunities: theory and practice.

Authors:  D Cavalla
Journal:  Br J Clin Pharmacol       Date:  2019-02-03       Impact factor: 4.335

2.  Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans.

Authors:  Nisha Singh; Ann L Sharpley; Uzay E Emir; Charles Masaki; Mohammad M Herzallah; Mark A Gluck; Trevor Sharp; Catherine J Harmer; Sridhar R Vasudevan; Philip J Cowen; Grant C Churchill
Journal:  Neuropsychopharmacology       Date:  2015-11-23       Impact factor: 7.853

3.  A safe lithium mimetic for bipolar disorder.

Authors:  Nisha Singh; Amy C Halliday; Justyn M Thomas; Olga V Kuznetsova; Rhiannon Baldwin; Esther C Y Woon; Parvinder K Aley; Ivi Antoniadou; Trevor Sharp; Sridhar R Vasudevan; Grant C Churchill
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

4.  Repositioning: the fast track to new anti-malarial medicines?

Authors:  Julie Lotharius; Francisco Javier Gamo-Benito; Iñigo Angulo-Barturen; Julie Clark; Michele Connelly; Santiago Ferrer-Bazaga; Tanya Parkinson; Pavithra Viswanath; Balachandra Bandodkar; Nikhil Rautela; Sowmya Bharath; Sandra Duffy; Vicky M Avery; Jörg J Möhrle; R Kiplin Guy; Timothy Wells
Journal:  Malar J       Date:  2014-04-14       Impact factor: 2.979

  4 in total

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