| Literature DB >> 19711889 |
Frank Versluis1, Itsuro Tomatsu, Seda Kehr, Carlo Fregonese, Armand W J W Tepper, Marc C A Stuart, Bart Jan Ravoo, Roman I Koning, Alexander Kros.
Abstract
A pH sensitive carrier is obtained by coating a cyclodextrin vesicle with an adamantane-terminated octapeptide through the formation of an inclusion complex. Upon lowering the pH from 7.4 to 5.0, the formation of peptide beta-sheets on the vesicle surface induces a transition of the bilayer from a sphere to a fiber. This transition is fully reversible and repeatable. The vesicles release their cargo upon fiber formation.Entities:
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Year: 2009 PMID: 19711889 DOI: 10.1021/ja9026264
Source DB: PubMed Journal: J Am Chem Soc ISSN: 0002-7863 Impact factor: 15.419