| Literature DB >> 23673149 |
Abstract
The excellent biocompatibility and unique inclusion capability as well as powerful functionalization capacity of cyclodextrins and their derivatives make them especially attractive for engineering novel functional materials for biomedical applications. There has been increasing interest recently to fabricate supramolecular systems for drug and gene delivery based on cyclodextrin materials. This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery. First, we introduce cyclodextrin materials utilized for self-assembly. The fabrication technologies of supramolecular systems including nanoplatforms and hydrogels as well as their applications in nanomedicine and pharmaceutical sciences are then highlighted. At the end, the future directions of this field are discussed.Entities:
Keywords: Amphiphile; Cyclodextrin; Drug delivery; Gene therapy; Hydrogel; Nanomedicine; Nanoparticle; Self-assembly; Supramolecular system
Mesh：
Substances：
Year: 2013 PMID： 23673149 PMCID： PMC3885994 DOI： 10.1016/j.addr.2013.05.001
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470