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Literature DB >> 19710715

An uphill battle toward pluripotency.

Abstract

The discovery that a cocktail of transcription factors can reprogram somatic cells into induced pluripotent stem (iPS) cells keeps revealing new secrets of cell fate specification. A new study with hematopoietic cells shows that progenitor cells are far more susceptible than differentiated cells to reprogramming.

Mesh：

Substances：
Transcription Factors

Year: 2009 PMID： 19710715 DOI： 10.1038/ng0909-960

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

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References

13 in total

1. Stepwise reprogramming of B cells into macrophages.

Authors: Huafeng Xie; Min Ye; Ru Feng; Thomas Graf
Journal: Cell Date: 2004-05-28 Impact factor: 41.582

2. Transplantation of Living Nuclei From Blastula Cells into Enucleated Frogs' Eggs.

Authors: R Briggs; T J King
Journal: Proc Natl Acad Sci U S A Date: 1952-05 Impact factor: 11.205

3. On the cloning of animals from terminally differentiated cells.

Authors: Konrad Hochedlinger; Rudolf Jaenisch
Journal: Nat Genet Date: 2007-02 Impact factor: 38.330

4. Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer.

Authors: Li-Ying Sung; Shaorong Gao; Hongmei Shen; Hui Yu; Yifang Song; Sadie L Smith; Ching-Chien Chang; Kimiko Inoue; Lynn Kuo; Jin Lian; Ao Li; X Cindy Tian; David P Tuck; Sherman M Weissman; Xiangzhong Yang; Tao Cheng
Journal: Nat Genet Date: 2006-10-01 Impact factor: 38.330

An uphill battle toward pluripotency.

1. Stepwise reprogramming of B cells into macrophages.

2. Transplantation of Living Nuclei From Blastula Cells into Enucleated Frogs' Eggs.

3. On the cloning of animals from terminally differentiated cells.

4. Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer.

Review 5. Stem cell states, fates, and the rules of attraction.

Review 6. Epigenetic reprogramming and induced pluripotency.

7. Dissecting direct reprogramming through integrative genomic analysis.

8. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

9. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors.

10. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds.