Literature DB >> 1969829

Autolysins are direct involved in the bactericidal effect caused by penicillin in wild type and in tolerant pneumococci.

R López1, C Ronda, E García.   

Abstract

The two pneumococcal autolytic enzymes (an N-acetylmuramoyl-L-alanine amidase and an endo-beta-1,4-N-acetylglucosaminidase) are directly involved in the penicillin-induced killing of Streptococcus pneumoniae. The activity of these lytic enzymes was efficiently controlled in tolerant mutants under physiological conditions.

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Year:  1990        PMID： 1969829     DOI： 10.1016/0378-1097(90)90305-a

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  7 in total

1.  Pneumococcal LytA autolysin, a potent therapeutic agent in experimental peritonitis-sepsis caused by highly beta-lactam-resistant Streptococcus pneumoniae.

Authors:  Violeta Rodríguez-Cerrato; Pedro García; Lorena Huelves; Ernesto García; Gema Del Prado; Matilde Gracia; Carmen Ponte; Rubens López; Francisco Soriano
Journal:  Antimicrob Agents Chemother       Date:  2007-06-18       Impact factor: 5.191

2.  In vitro bactericidal activity of the antiprotozoal drug miltefosine against Streptococcus pneumoniae and other pathogenic streptococci.

Authors:  Daniel Llull; Luis Rivas; Ernesto García
Journal:  Antimicrob Agents Chemother       Date:  2007-03-12       Impact factor: 5.191

3.  Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.

Authors:  Apoorva Bhatt; Laurent Kremer; Annie Z Dai; James C Sacchettini; William R Jacobs
Journal:  J Bacteriol       Date:  2005-11       Impact factor: 3.490

4.  Efficacies of cefotaxime and ceftriaxone in a mouse model of pneumonia induced by two penicillin- and cephalosporin-resistant strains of Streptococcus pneumoniae.

Authors:  C Sauve; E Azoulay-Dupuis; P Moine; C Darras-Joly; V Rieux; C Carbon; J P Bédos
Journal:  Antimicrob Agents Chemother       Date:  1996-12       Impact factor: 5.191

5.  A Staphylococcus aureus autolysin that has an N-acetylmuramoyl-L-alanine amidase domain and an endo-beta-N-acetylglucosaminidase domain: cloning, sequence analysis, and characterization.

Authors:  T Oshida; M Sugai; H Komatsuzawa; Y M Hong; H Suginaka; A Tomasz
Journal:  Proc Natl Acad Sci U S A       Date:  1995-01-03       Impact factor: 11.205

6.  Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium.

Authors:  Colin C Kietzman; Geli Gao; Beth Mann; Lance Myers; Elaine I Tuomanen
Journal:  Nat Commun       Date:  2016-02-29       Impact factor: 14.919

7.  In vitro bactericidal and bacteriolytic activity of ceragenin CSA-13 against planktonic cultures and biofilms of Streptococcus pneumoniae and other pathogenic streptococci.

Authors:  Miriam Moscoso; María Esteban-Torres; Margarita Menéndez; Ernesto García
Journal:  PLoS One       Date:  2014-07-09       Impact factor: 3.240
  7 in total

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