Literature DB >> 17576844

Pneumococcal LytA autolysin, a potent therapeutic agent in experimental peritonitis-sepsis caused by highly beta-lactam-resistant Streptococcus pneumoniae.

Violeta Rodríguez-Cerrato1, Pedro García, Lorena Huelves, Ernesto García, Gema Del Prado, Matilde Gracia, Carmen Ponte, Rubens López, Francisco Soriano.   

Abstract

The in vitro and in vivo antipneumococcal activities of the main pneumococcal autolysin (LytA) and Cpl-1, a lysozyme encoded by phage Cp-1, were studied. Intraperitoneal therapy with LytA or high-dose Cpl-1 remarkably reduced peritoneal bacterial counts (>5 log(10) CFU/ml) compared with those for the controls. After intravenous injection, LytA was the most effective treatment.

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Year:  2007        PMID： 17576844      PMCID： PMC2043201          DOI： 10.1128/AAC.00137-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Immobilization and single-step purification of fusion proteins using DEAE-cellulose.

Authors:  J M Sanchez-Puelles; J M Sanz; J L Garcia; E Garcia
Journal:  Eur J Biochem       Date:  1992-01-15

2.  Autolysins are direct involved in the bactericidal effect caused by penicillin in wild type and in tolerant pneumococci.

Authors:  R López; C Ronda; E García
Journal:  FEMS Microbiol Lett       Date:  1990-01-01       Impact factor: 2.742

3.  Mechanism of action of penicillin: triggering of the pneumococcal autolytic enzyme by inhibitors of cell wall synthesis.

Authors:  A Tomasz; S Waks
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

4.  Cloning, purification, and biochemical characterization of the pneumococcal bacteriophage Cp-1 lysin.

Authors:  J L García; E García; A Arrarás; P García; C Ronda; R López
Journal:  J Virol       Date:  1987-08       Impact factor: 5.103

5.  Choline-containing teichoic acid as a structural component of pneumococcal cell wall and its role in sensitivity to lysis by an autolytic enzyme.

Authors:  J L Mosser; A Tomasz
Journal:  J Biol Chem       Date:  1970-01-25       Impact factor: 5.157

Review 6.  The mechanism of the irreversible antimicrobial effects of penicillins: how the beta-lactam antibiotics kill and lyse bacteria.

Authors:  A Tomasz
Journal:  Annu Rev Microbiol       Date:  1979       Impact factor: 15.500

Review 7.  Bacteriophage lytic enzymes: novel anti-infectives.

Authors:  Vincent A Fischetti
Journal:  Trends Microbiol       Date:  2005-10       Impact factor: 17.079

8.  Correlation of pharmacodynamic parameters of five beta-lactam antibiotics with therapeutic efficacies in an animal model.

Authors:  F Soriano; P García-Corbeira; C Ponte; R Fernández-Roblas; I Gadea
Journal:  Antimicrob Agents Chemother       Date:  1996-12       Impact factor: 5.191

9.  Phage lytic enzyme Cpl-1 as a novel antimicrobial for pneumococcal bacteremia.

Authors:  Jutta M Loeffler; Svetolik Djurkovic; Vincent A Fischetti
Journal:  Infect Immun       Date:  2003-11       Impact factor: 3.441

10.  Specificity of the autolysin of Streptococcus (Diplococcus) pneumoniae.

Authors:  L V Howard; H Gooder
Journal:  J Bacteriol       Date:  1974-02       Impact factor: 3.490
  10 in total
  8 in total

1.  Cpl-7, a lysozyme encoded by a pneumococcal bacteriophage with a novel cell wall-binding motif.

Authors:  Noemí Bustamante; Nuria E Campillo; Ernesto García; Cristina Gallego; Benet Pera; Gregory P Diakun; José Luis Sáiz; Pedro García; J Fernando Díaz; Margarita Menéndez
Journal:  J Biol Chem       Date:  2010-08-18       Impact factor: 5.157

2.  In vitro destruction of Streptococcus pneumoniae biofilms with bacterial and phage peptidoglycan hydrolases.

Authors:  Mirian Domenech; Ernesto García; Miriam Moscoso
Journal:  Antimicrob Agents Chemother       Date:  2011-07-11       Impact factor: 5.191

3.  Improving the lethal effect of cpl-7, a pneumococcal phage lysozyme with broad bactericidal activity, by inverting the net charge of its cell wall-binding module.

Authors:  Roberto Díez-Martínez; Héctor D de Paz; Héctor de Paz; Noemí Bustamante; Ernesto García; Margarita Menéndez; Pedro García
Journal:  Antimicrob Agents Chemother       Date:  2013-08-19       Impact factor: 5.191

4.  Deciphering how Cpl-7 cell wall-binding repeats recognize the bacterial peptidoglycan.

Authors:  Noemí Bustamante; Manuel Iglesias-Bexiga; Noelia Bernardo-García; Noella Silva-Martín; Guadalupe García; María A Campanero-Rhodes; Esther García; Isabel Usón; Rubén M Buey; Pedro García; Juan A Hermoso; Marta Bruix; Margarita Menéndez
Journal:  Sci Rep       Date:  2017-11-28       Impact factor: 4.379

5.  Molecular Characterization of a Novel Lytic Enzyme LysC from Clostridium intestinale URNW and Its Antibacterial Activity Mediated by Positively Charged N-Terminal Extension.

Authors:  Magdalena Plotka; Monika Szadkowska; Maria Håkansson; Rebeka Kovačič; Salam Al-Karadaghi; Björn Walse; Olesia Werbowy; Anna-Karina Kaczorowska; Tadeusz Kaczorowski
Journal:  Int J Mol Sci       Date:  2020-07-11       Impact factor: 5.923

6.  Prediction of peptidoglycan hydrolases- a new class of antibacterial proteins.

Authors:  Ashok K Sharma; Sanjiv Kumar; Harish K; Darshan B Dhakan; Vineet K Sharma
Journal:  BMC Genomics       Date:  2016-05-27       Impact factor: 3.969

7.  PL3 Amidase, a Tailor-made Lysin Constructed by Domain Shuffling with Potent Killing Activity against Pneumococci and Related Species.

Authors:  Blas Blázquez; Alba Fresco-Taboada; Manuel Iglesias-Bexiga; Margarita Menéndez; Pedro García
Journal:  Front Microbiol       Date:  2016-07-28       Impact factor: 5.640

Review 8.  Choline Binding Proteins from Streptococcus pneumoniae: A Dual Role as Enzybiotics and Targets for the Design of New Antimicrobials.

Authors:  Beatriz Maestro; Jesús M Sanz
Journal:  Antibiotics (Basel)       Date:  2016-06-14
  8 in total

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