Literature DB >> 17353242

In vitro bactericidal activity of the antiprotozoal drug miltefosine against Streptococcus pneumoniae and other pathogenic streptococci.

Daniel Llull1, Luis Rivas, Ernesto García.   

Abstract

Miltefosine (hexadecylphosphocholine), the first oral drug against visceral leishmaniasis, triggered pneumococcal autolysis at concentrations higher than 2.5 microM. Bactericidal activity was also observed in cultures of other streptococci, although these failed to undergo lysis. The autolysis elicited by miltefosine can be attributed to triggering of the pneumococcal autolysin LytA.

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Year:  2007        PMID： 17353242      PMCID： PMC1855570          DOI： 10.1128/AAC.01428-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  44 in total

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Journal:  J Infect Dis       Date:  1991-08       Impact factor: 5.226

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Journal:  Arch Microbiol       Date:  1987       Impact factor: 2.552

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Journal:  Antimicrob Agents Chemother       Date:  2004-03       Impact factor: 5.191
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7.  Miltefosine Reduces the Cytolytic Activity and Virulence of Acinetobacter baumannii.

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8.  Bioactivity of miltefosine against aquatic stages of Schistosoma mansoni, Schistosoma haematobium and their snail hosts, supported by scanning electron microscopy.

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