Literature DB >> 19692993

Regulatory T cells that become autoaggressive.

Daniel Hawiger, Richard A Flavell.   

Abstract

Foxp3 expression is not stable and may be extinguished both in vitro and in vivo in regulatory T cells that convert into proinflammatory effector T cells. The loss of Foxp3 in regulatory T cells under autoimmune conditions may result in the conversion of suppressor T cells into highly autoaggressive lymphocytes.

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Year:  2009        PMID： 19692993     DOI： 10.1038/ni0909-938

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  11 in total

1.  Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.

Authors:  Luke M Williams; Alexander Y Rudensky
Journal:  Nat Immunol       Date:  2007-01-14       Impact factor: 25.606

2.  Foxp3-dependent programme of regulatory T-cell differentiation.

Authors:  Marc A Gavin; Jeffrey P Rasmussen; Jason D Fontenot; Valeria Vasta; Vincent C Manganiello; Joseph A Beavo; Alexander Y Rudensky
Journal:  Nature       Date:  2007-01-14       Impact factor: 49.962

Review 3.  Plasticity of CD4+ T cell lineage differentiation.

Authors:  Liang Zhou; Mark M W Chong; Dan R Littman
Journal:  Immunity       Date:  2009-05       Impact factor: 31.745

4.  Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches.

Authors:  Masayuki Tsuji; Noriko Komatsu; Shimpei Kawamoto; Keiichiro Suzuki; Osami Kanagawa; Tasuku Honjo; Shohei Hori; Sidonia Fagarasan
Journal:  Science       Date:  2009-03-13       Impact factor: 47.728

Review 5.  Foxp3+ regulatory T cells: differentiation, specification, subphenotypes.

Authors:  Markus Feuerer; Jonathan A Hill; Diane Mathis; Christophe Benoist
Journal:  Nat Immunol       Date:  2009-07       Impact factor: 25.606

6.  The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function.

Authors:  Ethan M Shevach; Dat Q Tran; Todd S Davidson; John Andersson
Journal:  Eur J Immunol       Date:  2008-04       Impact factor: 5.532

7.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.

Authors:  Jason D Fontenot; Marc A Gavin; Alexander Y Rudensky
Journal:  Nat Immunol       Date:  2003-03-03       Impact factor: 25.606

8.  Peripherally induced Treg: mode, stability, and role in specific tolerance.

Authors:  Irina Apostolou; Panos Verginis; Karsten Kretschmer; Julia Polansky; Jochen Hühn; Harald von Boehmer
Journal:  J Clin Immunol       Date:  2008-10-08       Impact factor: 8.317

Review 9.  Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.

Authors:  Shimon Sakaguchi
Journal:  Annu Rev Immunol       Date:  2004       Impact factor: 28.527

10.  Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo.

Authors:  Xuyu Zhou; Samantha L Bailey-Bucktrout; Lukas T Jeker; Cristina Penaranda; Marc Martínez-Llordella; Meredith Ashby; Maki Nakayama; Wendy Rosenthal; Jeffrey A Bluestone
Journal:  Nat Immunol       Date:  2009-07-26       Impact factor: 25.606
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  1 in total

1.  NAD(+) regulates Treg cell fate and promotes allograft survival via a systemic IL-10 production that is CD4(+) CD25(+) Foxp3(+) T cells independent.

Authors:  Abdallah Elkhal; Hector Rodriguez Cetina Biefer; Timm Heinbokel; Hirofumi Uehara; Markus Quante; Midas Seyda; Jeroen M Schuitenmaker; Felix Krenzien; Virginia Camacho; Miguel A de la Fuente; Ionita Ghiran; Stefan G Tullius
Journal:  Sci Rep       Date:  2016-03-01       Impact factor: 4.379
  1 in total

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