Literature DB >> 18395859

The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function.

Ethan M Shevach1, Dat Q Tran, Todd S Davidson, John Andersson.   

Abstract

Stimulation of mouse CD4+ T cells in the presence of TGF-beta results in the expression of Foxp3 and induction of Treg function. Stimulation of human CD4+ T cells under similar conditions results in the expression of Foxp3, but the cells lack regulatory cell function. TGF-beta expressed on the surface of Treg also induces Foxp3 expression and Treg function in responder cells. Both of these mechanisms may play a role in vivo in the induction of antigen-specific extra-thymic Treg.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18395859      PMCID： PMC2662375          DOI： 10.1002/eji.200738111

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  15 in total

1.  Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7.

Authors:  Massimo C Fantini; Christoph Becker; Giovanni Monteleone; Francesco Pallone; Peter R Galle; Markus F Neurath
Journal:  J Immunol       Date:  2004-05-01       Impact factor: 5.422

2.  TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling.

Authors:  Takatoku Oida; Lili Xu; Howard L Weiner; Atsushi Kitani; Warren Strober
Journal:  J Immunol       Date:  2006-08-15       Impact factor: 5.422

3.  Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells.

Authors:  Todd S Davidson; Richard J DiPaolo; John Andersson; Ethan M Shevach
Journal:  J Immunol       Date:  2007-04-01       Impact factor: 5.422

4.  TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation.

Authors:  Marika C Kullberg; Valerie Hay; Allen W Cheever; Mizuko Mamura; Alan Sher; John J Letterio; Ethan M Shevach; Ciriaco A Piccirillo
Journal:  Eur J Immunol       Date:  2005-10       Impact factor: 5.532

5.  Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells.

Authors:  Mindi R Walker; Deborah J Kasprowicz; Vivian H Gersuk; Angele Benard; Megan Van Landeghen; Jane H Buckner; Steven F Ziegler
Journal:  J Clin Invest       Date:  2003-11       Impact factor: 14.808

6.  T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation.

Authors:  Ming O Li; Yisong Y Wan; Richard A Flavell
Journal:  Immunity       Date:  2007-05-03       Impact factor: 31.745

7.  CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome.

Authors:  Song Guo Zheng; Ju Hua Wang; Michael N Koss; Francisco Quismorio; J Dixon Gray; David Allen Horwitz
Journal:  J Immunol       Date:  2004-02-01       Impact factor: 5.422

8.  Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta.

Authors:  K Nakamura; A Kitani; W Strober
Journal:  J Exp Med       Date:  2001-09-03       Impact factor: 14.307

9.  CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness.

Authors:  Ciriaco A Piccirillo; John J Letterio; Angela M Thornton; Rebecca S McHugh; Mizuko Mamura; Hidekazu Mizuhara; Ethan M Shevach
Journal:  J Exp Med       Date:  2002-07-15       Impact factor: 14.307

10.  Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.

Authors:  WanJun Chen; Wenwen Jin; Neil Hardegen; Ke-Jian Lei; Li Li; Nancy Marinos; George McGrady; Sharon M Wahl
Journal:  J Exp Med       Date:  2003-12-15       Impact factor: 14.307
View more
  41 in total

1.  T regulatory cells participate in the control of germinal centre reactions.

Authors:  Carla-Maria Alexander; Lorraine T Tygrett; Alexander W Boyden; Kristy L Wolniak; Kevin L Legge; Thomas J Waldschmidt
Journal:  Immunology       Date:  2011-06-03       Impact factor: 7.397

2.  Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion.

Authors:  Yong Chan Kim; Ravikiran Bhairavabhotla; Jeongheon Yoon; Amit Golding; Angela M Thornton; Dat Q Tran; Ethan M Shevach
Journal:  Blood       Date:  2012-01-31       Impact factor: 22.113

Review 3.  The biology of FoxP3: a key player in immune suppression during infections, autoimmune diseases and cancer.

Authors:  Frances Mercer; Derya Unutmaz
Journal:  Adv Exp Med Biol       Date:  2009       Impact factor: 2.622

4.  An Immunosuppressive Dendritic Cell Subset Accumulates at Secondary Sites and Promotes Metastasis in Pancreatic Cancer.

Authors:  Justin A Kenkel; William W Tseng; Matthew G Davidson; Lorna L Tolentino; Okmi Choi; Nupur Bhattacharya; E Scott Seeley; Daniel A Winer; Nathan E Reticker-Flynn; Edgar G Engleman
Journal:  Cancer Res       Date:  2017-06-13       Impact factor: 12.701

5.  Regulatory T cells that become autoaggressive.

Authors:  Daniel Hawiger; Richard A Flavell
Journal:  Nat Immunol       Date:  2009-09       Impact factor: 25.606

6.  Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors.

Authors:  Frances Mercer; Alka Khaitan; Lina Kozhaya; Judith A Aberg; Derya Unutmaz
Journal:  J Immunol       Date:  2014-06-23       Impact factor: 5.422

7.  Immunization against TGF-β1 reduces collagen deposition but increases sustained inflammation in a murine asthma model.

Authors:  Yanbing Ma; Weiwei Huang; Cunbao Liu; Yang Li; Ye Xia; Xu Yang; Wenjia Sun; Hongmei Bai; Qihan Li; Zhikang Peng
Journal:  Hum Vaccin Immunother       Date:  2016-02-22       Impact factor: 3.452

8.  CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4(+) regulatory T cells.

Authors:  Jian Zheng; Yinping Liu; Yu-Lung Lau; Wenwei Tu
Journal:  Cell Mol Immunol       Date:  2010-01       Impact factor: 11.530

9.  Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites.

Authors:  Lilian Lacerda Bueno; Cristiane Guimarães Morais; Fernanda Fortes Araújo; Juliana Assis Silva Gomes; Rodrigo Corrêa-Oliveira; Irene Silva Soares; Marcus Vinícius Lacerda; Ricardo Toshio Fujiwara; Erika Martins Braga
Journal:  PLoS One       Date:  2010-03-10       Impact factor: 3.240

10.  Plasmodium falciparum-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta.

Authors:  Anja Scholzen; Diana Mittag; Stephen J Rogerson; Brian M Cooke; Magdalena Plebanski
Journal:  PLoS Pathog       Date:  2009-08-14       Impact factor: 6.823
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.