Literature DB >> 19692989

From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development.

Anne O'Garra1, Kenneth M Murphy.   

Abstract

The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19692989     DOI： 10.1038/ni0909-929

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  38 in total

Review 1.  TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.

Authors:  T R Mosmann; R L Coffman
Journal:  Annu Rev Immunol       Date:  1989       Impact factor: 28.527

Review 2.  Interleukin-10 and the interleukin-10 receptor.

Authors:  K W Moore; R de Waal Malefyt; R L Coffman; A O'Garra
Journal:  Annu Rev Immunol       Date:  2001       Impact factor: 28.527

3.  Regulation of interleukin 12 p40 expression through an NF-kappa B half-site.

Authors:  T L Murphy; M G Cleveland; P Kulesza; J Magram; K M Murphy
Journal:  Mol Cell Biol       Date:  1995-10       Impact factor: 4.272

4.  Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from alpha beta TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-gamma production is IFN-gamma-dependent.

Authors:  S E Macatonia; C S Hsieh; K M Murphy; A O'Garra
Journal:  Int Immunol       Date:  1993-09       Impact factor: 4.823

5.  Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo.

Authors:  K M Murphy; A B Heimberger; D Y Loh
Journal:  Science       Date:  1990-12-21       Impact factor: 47.728

6.  Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI.

Authors:  K W Moore; P Vieira; D F Fiorentino; M L Trounstine; T A Khan; T R Mosmann
Journal:  Science       Date:  1990-06-08       Impact factor: 47.728

Review 7.  Further checkpoints in Th1 development.

Authors:  Douglas S Robinson; Anne O'Garra
Journal:  Immunity       Date:  2002-06       Impact factor: 31.745

8.  Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.

Authors:  C S Hsieh; S E Macatonia; C S Tripp; S F Wolf; A O'Garra; K M Murphy
Journal:  Science       Date:  1993-04-23       Impact factor: 47.728

9.  Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

Authors:  A Poltorak; X He; I Smirnova; M Y Liu; C Van Huffel; X Du; D Birdwell; E Alejos; M Silva; C Galanos; M Freudenberg; P Ricciardi-Castagnoli; B Layton; B Beutler
Journal:  Science       Date:  1998-12-11       Impact factor: 47.728

10.  Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

Authors:  D F Fiorentino; M W Bond; T R Mosmann
Journal:  J Exp Med       Date:  1989-12-01       Impact factor: 14.307
View more
  71 in total

1.  Interleukin-10 ablation promotes tumor development, growth, and metastasis.

Authors:  Takashi Tanikawa; Cailin Moira Wilke; Ilona Kryczek; Grace Y Chen; John Kao; Gabriel Núñez; Weiping Zou
Journal:  Cancer Res       Date:  2011-11-28       Impact factor: 12.701

2.  Interleukin-12 (IL-12)/IL-10 ratio as a marker of disease severity in Crimean-Congo hemorrhagic fever.

Authors:  Dionysios C Watson; Maria Sargianou; George Panos
Journal:  Clin Vaccine Immunol       Date:  2012-05

3.  Curcumin induces maturation-arrested dendritic cells that expand regulatory T cells in vitro and in vivo.

Authors:  N M Rogers; S Kireta; P T H Coates
Journal:  Clin Exp Immunol       Date:  2010-12       Impact factor: 4.330

4.  Structure-activity relationships in toll-like receptor 2-agonists leading to simplified monoacyl lipopeptides.

Authors:  Geetanjali Agnihotri; Breanna M Crall; Tyler C Lewis; Timothy P Day; Rajalakshmi Balakrishna; Hemamali J Warshakoon; Subbalakshmi S Malladi; Sunil A David
Journal:  J Med Chem       Date:  2011-11-04       Impact factor: 7.446

5.  Quantitative events determine the differentiation and function of helper T cells.

Authors:  Anne O'Garra; Leona Gabryšová; Hergen Spits
Journal:  Nat Immunol       Date:  2011-04       Impact factor: 25.606

6.  Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi.

Authors:  Braulia C Caetano; Bianca B Carmo; Mariane B Melo; Anna Cerny; Sara L dos Santos; Daniella C Bartholomeu; Douglas T Golenbock; Ricardo T Gazzinelli
Journal:  J Immunol       Date:  2011-07-13       Impact factor: 5.422

7.  Effect of IL12A and IL12B polymorphisms on the risk of Chlamydia trachomatis-induced tubal factor infertility and disease severity.

Authors:  H Ohman; R Bailey; A Natividad; J Ragoussis; L-L Johnson; A Tiitinen; M Halttunen; J Paavonen; H-M Surcel
Journal:  Hum Reprod       Date:  2012-05-11       Impact factor: 6.918

8.  High macrophage PD-L1 expression not responsible for T cell suppression.

Authors:  Naomi Goldman; Yelizavet D Lomakova; Jennifer Londregan; Amanda Bucknum; Kelley DePierri; John Somerville; James E Riggs
Journal:  Cell Immunol       Date:  2017-12-30       Impact factor: 4.868

9.  mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo.

Authors:  Dàlia Raïch-Regué; Brian R Rosborough; Alicia R Watson; Mandy J McGeachy; Hēth R Turnquist; Angus W Thomson
Journal:  J Immunol       Date:  2015-04-03       Impact factor: 5.422

10.  Characterisation of the protective immune response following subcutaneous vaccination of susceptible mice against Trichuris muris.

Authors:  Helen Dixon; Matthew C Little; Kathryn J Else
Journal:  Int J Parasitol       Date:  2009-12-05       Impact factor: 3.981
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.