Literature DB >> 12121657

Further checkpoints in Th1 development.

Douglas S Robinson1, Anne O'Garra.   

Abstract

Tight control of Th1 immunity is essential to prevent immunopathology. Central to control of the IFN-gamma gene is the transcription factor T-bet, whose induction is Stat-1 dependent. IL-12 is dominant in directing Th1 development, while synergizing with IL-18 for IFNgamma production from differentiated Th1 cells. In this issue of Immunity, IL-27 is described, which acts in synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-1. We review the coordination of these checkpoints in Th1 development and function.

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Year:  2002        PMID： 12121657     DOI： 10.1016/s1074-7613(02)00331-x

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  52 in total

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2.  Adenylate cyclase toxin from Bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of Th2 and regulatory T cells.

Authors:  Pádraig J Ross; Ed C Lavelle; Kingston H G Mills; Aoife P Boyd
Journal:  Infect Immun       Date:  2004-03       Impact factor: 3.441

3.  Differential expression of the cytokine receptors for human interleukin (IL)-12 and IL-18 on lymphocytes of both CD45RA and CD45RO phenotype from tonsils, cord and adult peripheral blood.

Authors:  M Bofill; E Almirall; A McQuaid; R Peña; R Ruiz-Hernandez; M Naranjo; L Ruiz; B Clotet; F E Borràs
Journal:  Clin Exp Immunol       Date:  2004-12       Impact factor: 4.330

4.  Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis.

Authors:  Frank Leithäuser; Tamara Meinhardt-Krajina; Kerstin Fink; Beate Wotschke; Peter Möller; Jörg Reimann
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Review 5.  Neonatal innate immunity to infectious agents.

Authors:  László Maródi
Journal:  Infect Immun       Date:  2006-04       Impact factor: 3.441

6.  Helminth-primed dendritic cells alter the host response to enteric bacterial infection.

Authors:  Chien-Chang Chen; Steve Louie; Beth A McCormick; W Allan Walker; Hai Ning Shi
Journal:  J Immunol       Date:  2006-01-01       Impact factor: 5.422

Review 7.  Statins--treatment option for central nervous system autoimmune disease?

Authors:  Martin S Weber; Lawrence Steinman; Scott S Zamvil
Journal:  Neurotherapeutics       Date:  2007-10       Impact factor: 7.620

8.  Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow.

Authors:  Rosalba Salcedo; Julie A Hixon; Jimmy K Stauffer; Rashmi Jalah; Alan D Brooks; Tahira Khan; Ren-Ming Dai; Loretta Scheetz; Erin Lincoln; Timothy C Back; Douglas Powell; Arthur A Hurwitz; Thomas J Sayers; Robert Kastelein; George N Pavlakis; Barbara K Felber; Giorgio Trinchieri; Jon M Wigginton
Journal:  J Immunol       Date:  2009-04-01       Impact factor: 5.422

9.  Ultrathin polymeric coatings based on hydrogen-bonded polyphenol for protection of pancreatic islet cells.

Authors:  Veronika Kozlovskaya; Oleksandra Zavgorodnya; Yi Chen; Kristin Ellis; Hubert M Tse; Wanxing Cui; J Anthony Thompson; Eugenia Kharlampieva
Journal:  Adv Funct Mater       Date:  2012-04-30       Impact factor: 18.808

10.  Dendritic cells induce immunity and long-lasting protection against blood-stage malaria despite an in vitro parasite-induced maturation defect.

Authors:  Dodie S Pouniotis; Owen Proudfoot; Violeta Bogdanoska; Vasso Apostolopoulos; Theodora Fifis; Magdalena Plebanski
Journal:  Infect Immun       Date:  2004-09       Impact factor: 3.441
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