BACKGROUND: Young patients represent an increasing subgroup with head and neck cancer. METHODS: Patients between 18 and 39 years of age with newly diagnosed and previously untreated squamous cell cancers were identified. RESULTS: Seventy-eight patients met the selection criteria: 28 patients were never-smokers/never-drinkers (NSNDs), and 50 patients reported tobacco or alcohol abuse (smokers and/or drinkers [SD]). NSND patients were diagnosed at a younger median age (31.5 years vs 35.5 years, p = .007), were more likely to be female (75% vs 30%, p < .001) and white (89% vs 60%, p = .006), and were more likely to have tumors of the oral tongue (57% vs 24%, p = .003) and T1 disease (47% vs 20%, p = .01). There was no difference in 10-year relapse-free survival, but a suggestion of improved 10-year overall survival for NSND patients (71% vs 46%, p = .10). CONCLUSIONS: Young patients with head and neck squamous cell carcinoma (HNSCC) appear to have unique clinical profiles based on history of alcohol and tobacco abuse.
BACKGROUND: Young patients represent an increasing subgroup with head and neck cancer. METHODS:Patients between 18 and 39 years of age with newly diagnosed and previously untreated squamous cell cancers were identified. RESULTS: Seventy-eight patients met the selection criteria: 28 patients were never-smokers/never-drinkers (NSNDs), and 50 patients reported tobacco or alcohol abuse (smokers and/or drinkers [SD]). NSND patients were diagnosed at a younger median age (31.5 years vs 35.5 years, p = .007), were more likely to be female (75% vs 30%, p < .001) and white (89% vs 60%, p = .006), and were more likely to have tumors of the oral tongue (57% vs 24%, p = .003) and T1 disease (47% vs 20%, p = .01). There was no difference in 10-year relapse-free survival, but a suggestion of improved 10-year overall survival for NSND patients (71% vs 46%, p = .10). CONCLUSIONS: Young patients with head and neck squamous cell carcinoma (HNSCC) appear to have unique clinical profiles based on history of alcohol and tobacco abuse.
Authors: Ryan Li; Daniel L Faden; Carole Fakhry; Chaz Langelier; Yuchen Jiao; Yuxuan Wang; Matthew D Wilkerson; Chandra Sekhar Pedamallu; Matthew Old; James Lang; Myriam Loyo; Sun Mi Ahn; Marietta Tan; Zhen Gooi; Jason Chan; Jeremy Richmon; Laura D Wood; Ralph H Hruban; Justin Bishop; William H Westra; Christine H Chung; Joseph Califano; Christine G Gourin; Chetan Bettegowda; Matthew Meyerson; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Joseph L DeRisi; Wayne M Koch; Nishant Agrawal Journal: Head Neck Date: 2014-08-23 Impact factor: 3.147
Authors: Morgan A Gingerich; Joshua D Smith; Nicole L Michmerhuizen; Megan Ludwig; Samantha Devenport; Chloe Matovina; Chad Brenner; Steven B Chinn Journal: Head Neck Date: 2018-02-10 Impact factor: 3.147
Authors: Ekaterina G Shatalova; Andres J P Klein-Szanto; Karthik Devarajan; Edna Cukierman; Margie L Clapper Journal: Cancer Prev Res (Phila) Date: 2012-12-31
Authors: Ian-James Malm; Lisa M Rooper; Justin A Bishop; Selmin Karatayli Ozgursoy; Alexander T Hillel; Lee M Akst; Simon R Best Journal: Am J Otolaryngol Date: 2018-11-22 Impact factor: 1.808
Authors: Benjamin R Campbell; James L Netterville; Robert J Sinard; Kyle Mannion; Sarah L Rohde; Alexander Langerman; Young J Kim; James S Lewis; Krystle A Lang Kuhs Journal: Oral Oncol Date: 2018-10-14 Impact factor: 5.337