Morgan A Gingerich1, Joshua D Smith2, Nicole L Michmerhuizen2,3, Megan Ludwig2,1, Samantha Devenport2,1, Chloe Matovina2, Chad Brenner2,1,4, Steven B Chinn2,4. 1. Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, Michigan. 2. Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan. 3. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan. 4. Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan.
Abstract
BACKGROUND: The past 2 decades have seen an increased incidence of head and neck squamous cell carcinoma (HNSCC) in a nontraditional, low-risk patient population (ie, ≤45 years of age, no substance use history), owing to a combination of human papillomavirus (HPV) infection and individual genetic variation. METHODS: Articles positing genetic variants as contributing factors in HNSCC incidence in low-risk, nontraditional patients were identified using a PubMed search, reviewed in detail, and concisely summarized herein. RESULTS: Recent data suggest that common polymorphisms in DNA repair enzymes, cell-cycle control proteins, apoptotic pathway members, and Fanconi anemia-associated genes likely modulate susceptibility to HNSCC development in low-risk, nontraditional patients. CONCLUSION: At present, there is a lack of robust, comprehensive data on genetic drivers of oncogenesis in low-risk patients and a clear need for further research on genetic alterations underlying the rising incidence of HNSCC in low-risk, nontraditional patients.
BACKGROUND: The past 2 decades have seen an increased incidence of head and neck squamous cell carcinoma (HNSCC) in a nontraditional, low-risk patient population (ie, ≤45 years of age, no substance use history), owing to a combination of humanpapillomavirus (HPV) infection and individual genetic variation. METHODS: Articles positing genetic variants as contributing factors in HNSCC incidence in low-risk, nontraditional patients were identified using a PubMed search, reviewed in detail, and concisely summarized herein. RESULTS: Recent data suggest that common polymorphisms in DNA repair enzymes, cell-cycle control proteins, apoptotic pathway members, and Fanconi anemia-associated genes likely modulate susceptibility to HNSCC development in low-risk, nontraditional patients. CONCLUSION: At present, there is a lack of robust, comprehensive data on genetic drivers of oncogenesis in low-risk patients and a clear need for further research on genetic alterations underlying the rising incidence of HNSCC in low-risk, nontraditional patients.
Authors: Xiaoxiang Guan; Erich M Sturgis; Dapeng Lei; Zhensheng Liu; Kristina R Dahlstrom; Qingyi Wei; Guojun Li Journal: Clin Cancer Res Date: 2010-02-23 Impact factor: 12.531
Authors: Virginia G Kaklamani; Lisa Baddi; Junjian Liu; Diana Rosman; Sharbani Phukan; Ciarán Bradley; Chris Hegarty; Bree McDaniel; Alfred Rademaker; Carole Oddoux; Harry Ostrer; Loren S Michel; Helen Huang; Yu Chen; Habibul Ahsan; Kenneth Offit; Boris Pasche Journal: Cancer Res Date: 2005-04-15 Impact factor: 12.701
Authors: Chantal Stoepker; Najim Ameziane; Petra van der Lelij; Irsan E Kooi; Anneke B Oostra; Martin A Rooimans; Saskia E van Mil; Arjen Brink; Ralf Dietrich; Jesper A Balk; Bauke Ylstra; Hans Joenje; Stephan M Feller; Ruud H Brakenhoff Journal: Cancer Res Date: 2015-06-29 Impact factor: 12.701
Authors: Steve Tremblay; Patricia Pintor Dos Reis; Grace Bradley; Natalie Naranjo Galloni; Bayardo Perez-Ordonez; Jeremy Freeman; Dale Brown; Ralph Gilbert; Patrick Gullane; Jonathan Irish; Suzanne Kamel-Reid Journal: Arch Otolaryngol Head Neck Surg Date: 2006-09
Authors: Rubén Cabanillas; Aurora Astudillo; Miguel Valle; Jorge de la Rosa; Rebeca Álvarez; Noelia S Durán; Juan Cadiñanos Journal: Head Neck Date: 2011-11-15 Impact factor: 3.147
Authors: Tatiana Natasha Toporcov; Ariana Znaor; Zuo-Feng Zhang; Guo-Pei Yu; Deborah M Winn; Qingyi Wei; Marta Vilensky; Thomas Vaughan; Peter Thomson; Renato Talamini; Neonila Szeszenia-Dabrowska; Erich M Sturgis; Elaine Smith; Oxana Shangina; Stephen M Schwartz; Stimson Schantz; Peter Rudnai; Lorenzo Richiardi; Heribert Ramroth; Mark P Purdue; Andrew F Olshan; José Eluf-Neto; Joshua Muscat; Raquel Ajub Moyses; Hal Morgenstern; Ana Menezes; Michael McClean; Keitaro Matsuo; Dana Mates; Tatiana V Macfarlane; Jolanta Lissowska; Fabio Levi; Philip Lazarus; Carlo La Vecchia; Pagona Lagiou; Sergio Koifman; Kristina Kjaerheim; Karl Kelsey; Ivana Holcatova; Rolando Herrero; Claire Healy; Richard B Hayes; Silvia Franceschi; Leticia Fernandez; Eleonora Fabianova; Alexander W Daudt; Otávio Alberto Curioni; Luigino Dal Maso; Maria Paula Curado; David I Conway; Chu Chen; Xavier Castellsague; Cristina Canova; Gabriella Cadoni; Paul Brennan; Stefania Boccia; José Leopoldo Ferreira Antunes; Wolfgang Ahrens; Antonio Agudo; Paolo Boffetta; Mia Hashibe; Yuan-Chin Amy Lee; Victor Wünsch Filho Journal: Int J Epidemiol Date: 2015-01-22 Impact factor: 7.196
Authors: Xicheng Song; Erich M Sturgis; Jun Liu; Lei Jin; Zhongqiu Wang; Caiyun Zhang; Qingyi Wei; Guojun Li Journal: PLoS One Date: 2013-02-15 Impact factor: 3.240