BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in type 2 diabetes mellitus (T2DM) patients. We examined the relationship between CVD in different vascular territories. METHODS: T2DM patients without known or suspected CVD (n = 305) referred consecutively to a diabetes clinic for the first time and age-matched nondiabetic reference subjects (n = 40) were screened for myocardial ischemia, carotid, and peripheral arterial disease by means of myocardial perfusion scintigraphy, carotid artery ultrasonography, and peripheral ankle and toe systolic blood pressure measurements. RESULTS: In the T2DM patients, the prevalence of myocardial ischemia, carotid, and peripheral arterial disease was 30%, 42%, and 15%, respectively, almost three times higher than in the reference subjects (P = 0.007, P = 0.001, and P = 0.09, respectively). T2DM patients with myocardial ischemia, carotid, or peripheral arterial disease had a significantly increased risk of CVD in other vascular territories as well (OR: 1.99, 2.09, and 3.09, respectively). However, 40%, 52%, and 22% of the T2DM patients with myocardial ischemia, carotid, or peripheral arterial disease demonstrated exclusively this particular type of CVD manifestation. CONCLUSIONS: In T2DM patients, signs of CVD in one vascular territory carry a significantly increased risk of CVD in other territories, although many patients only presented one manifestation.
BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in type 2 diabetes mellitus (T2DM) patients. We examined the relationship between CVD in different vascular territories. METHODS: T2DM patients without known or suspected CVD (n = 305) referred consecutively to a diabetes clinic for the first time and age-matched nondiabetic reference subjects (n = 40) were screened for myocardial ischemia, carotid, and peripheral arterial disease by means of myocardial perfusion scintigraphy, carotid artery ultrasonography, and peripheral ankle and toe systolic blood pressure measurements. RESULTS: In the T2DM patients, the prevalence of myocardial ischemia, carotid, and peripheral arterial disease was 30%, 42%, and 15%, respectively, almost three times higher than in the reference subjects (P = 0.007, P = 0.001, and P = 0.09, respectively). T2DM patients with myocardial ischemia, carotid, or peripheral arterial disease had a significantly increased risk of CVD in other vascular territories as well (OR: 1.99, 2.09, and 3.09, respectively). However, 40%, 52%, and 22% of the T2DM patients with myocardial ischemia, carotid, or peripheral arterial disease demonstrated exclusively this particular type of CVD manifestation. CONCLUSIONS: In T2DM patients, signs of CVD in one vascular territory carry a significantly increased risk of CVD in other territories, although many patients only presented one manifestation.
Authors: S M Haffner; R D Agostino; M F Saad; D H O'Leary; P J Savage; M Rewers; J Selby; R N Bergman; L Mykkänen Journal: Am J Cardiol Date: 2000-06-15 Impact factor: 2.778
Authors: A T Hirsch; M H Criqui; D Treat-Jacobson; J G Regensteiner; M A Creager; J W Olin; S H Krook; D B Hunninghake; A J Comerota; M E Walsh; M M McDermott; W R Hiatt Journal: JAMA Date: 2001-09-19 Impact factor: 56.272
Authors: A R Folsom; J H Eckfeldt; S Weitzman; J Ma; L E Chambless; R W Barnes; K B Cram; R G Hutchinson Journal: Stroke Date: 1994-01 Impact factor: 7.914
Authors: M K Poulsen; J E Henriksen; W Vach; J Dahl; J E Møller; A Johansen; O Gerke; T Haghfelt; P F Høilund-Carlsen; H Beck-Nielsen Journal: Diabetologia Date: 2010-01-14 Impact factor: 10.122
Authors: Mikael K Poulsen; Mads Nybo; Jordi Dahl; Susanne Hosbond; Tina S Poulsen; Allan Johansen; Poul F Høilund-Carlsen; Henning Beck-Nielsen; Lars M Rasmussen; Jan E Henriksen Journal: Cardiovasc Diabetol Date: 2011-08-12 Impact factor: 9.951
Authors: Henrik Reinhard; Niels Wiinberg; Peter R Hansen; Andreas Kjær; Claus L Petersen; Kaj Winther; Hans-Henrik Parving; Peter Rossing; Peter K Jacobsen Journal: Cardiovasc Diabetol Date: 2011-08-03 Impact factor: 9.951
Authors: Lise Pedersen; Mads Nybo; Mikael Kjær Poulsen; Jan Erik Henriksen; Jordi Dahl; Lars Melholt Rasmussen Journal: BMC Cardiovasc Disord Date: 2014-12-19 Impact factor: 2.298
Authors: Antonino De Lorenzo; Santo Gratteri; Paola Gualtieri; Andrea Cammarano; Pierfrancesco Bertucci; Laura Di Renzo Journal: J Transl Med Date: 2019-05-22 Impact factor: 5.531