UNLABELLED: In 1996, a committee on renal clearance recommended a mean sojourn time-based methodology for single-sample determination of plasma clearance of 99mTc-diethylenetriamine pentaacetic acid (DTPA) to be used on adults if the patient's glomerular filtration rate (GFR) is suspected to be >30 ml/min. The main purpose of this study was to derive a mean sojourn time-based formula for calculation of 51Cr-ethylenediamine tetraacetic acid (EDTA) clearance in adults. METHODS: Two groups of patients with 51Cr-EDTA clearance (Cl) between 16 and 172 ml/min were studied. In Group I (n = 46), reference Cl was determined as a multiplasma sample, single-injection method (ClSM). Sixteen blood samples were drawn from 0 until 5 hr after a single intravenous injection of 51Cr-EDTA. In Group II (n = 1046), reference Cl was determined by the Brøchner-Mortensen four-sample clearance method (ClBM). The plasma time-activity curves of Group I were used to derive two mean sojourn time-based formulas (Formulas 1 and 2) for calculation of a single-sample clearance. Formula 1 was derived from the entire time-activity curve, whereas the derivation of Formula 2 used only the final slope of the time-activity curve. The accuracy of the two formulas and the Christensen and Groth 99mTc-DTPA formula was tested on Group II. RESULTS: Chromium-51-EDTA Cl calculated by Formula 1 was almost identical to the Cl calculated by the reference Cl method (r = 0.982; SDdiff = 5.82 ml/min). Both 51Cr-EDTA Cl calculated by Formula 2 and by the 99mTc-DTPA formula showed close correlation with the reference method (r = 0.976, r = 0.985, respectively) but systematically overestimated GFR for the whole range of clearance values by 3.5 and 3.2 ml/min (p<0.001), respectively. CONCLUSION: It is possible to get an accurate determination of 51Cr-EDTA Cl from a single-plasma sample in adults by the mean sojourn time methodology. The determination is marginally more accurate (p<0.001) if using a formula derived from the entire plasma time-activity curve than from only the final slope. The single-sample formula derived for determination of 99mTc-DTPA Cl tends slightly to overestimate GFR if used to calculate 51Cr-EDTA Cl.
UNLABELLED: In 1996, a committee on renal clearance recommended a mean sojourn time-based methodology for single-sample determination of plasma clearance of 99mTc-diethylenetriamine pentaacetic acid (DTPA) to be used on adults if the patient's glomerular filtration rate (GFR) is suspected to be >30 ml/min. The main purpose of this study was to derive a mean sojourn time-based formula for calculation of 51Cr-ethylenediamine tetraacetic acid (EDTA) clearance in adults. METHODS: Two groups of patients with 51Cr-EDTA clearance (Cl) between 16 and 172 ml/min were studied. In Group I (n = 46), reference Cl was determined as a multiplasma sample, single-injection method (ClSM). Sixteen blood samples were drawn from 0 until 5 hr after a single intravenous injection of 51Cr-EDTA. In Group II (n = 1046), reference Cl was determined by the Brøchner-Mortensen four-sample clearance method (ClBM). The plasma time-activity curves of Group I were used to derive two mean sojourn time-based formulas (Formulas 1 and 2) for calculation of a single-sample clearance. Formula 1 was derived from the entire time-activity curve, whereas the derivation of Formula 2 used only the final slope of the time-activity curve. The accuracy of the two formulas and the Christensen and Groth 99mTc-DTPA formula was tested on Group II. RESULTS:Chromium-51-EDTA Cl calculated by Formula 1 was almost identical to the Cl calculated by the reference Cl method (r = 0.982; SDdiff = 5.82 ml/min). Both 51Cr-EDTA Cl calculated by Formula 2 and by the 99mTc-DTPA formula showed close correlation with the reference method (r = 0.976, r = 0.985, respectively) but systematically overestimated GFR for the whole range of clearance values by 3.5 and 3.2 ml/min (p<0.001), respectively. CONCLUSION: It is possible to get an accurate determination of 51Cr-EDTA Cl from a single-plasma sample in adults by the mean sojourn time methodology. The determination is marginally more accurate (p<0.001) if using a formula derived from the entire plasma time-activity curve than from only the final slope. The single-sample formula derived for determination of 99mTc-DTPA Cl tends slightly to overestimate GFR if used to calculate 51Cr-EDTA Cl.
Authors: Mikael K Poulsen; Jan Erik Henriksen; Jordi Dahl; Allan Johansen; Jacob E Møller; Oke Gerke; Werner Vach; Torben Haghfelt; Henning Beck-Nielsen; Poul Flemming Høilund-Carlsen Journal: J Nucl Cardiol Date: 2009-08-14 Impact factor: 5.952
Authors: William E Moody; Charles J Ferro; Nicola C Edwards; Colin D Chue; Erica Lai Sze Lin; Robin J Taylor; Paul Cockwell; Richard P Steeds; Jonathan N Townend Journal: Hypertension Date: 2016-02 Impact factor: 10.190
Authors: Anna M Price; William E Moody; Victoria M Stoll; Ravi Vijapurapu; Manvir K Hayer; Luca Biasiolli; Chris J Weston; Rachel Webster; Roman Wesolowski; Kirsty C McGee; Boyang Liu; Shanat Baig; Luke C Pickup; Ashwin Radhakrishnan; Jonathan P Law; Nicola C Edwards; Richard P Steeds; Charles J Ferro; Jonathan N Townend Journal: Hypertension Date: 2021-02-08 Impact factor: 10.190
Authors: Anna M Price; George H B Greenhall; William E Moody; Richard P Steeds; Patrick B Mark; Nicola C Edwards; Manvir K Hayer; Luke C Pickup; Ashwin Radhakrishnan; Jonathan P Law; Debasish Banerjee; Tunde Campbell; Charles R V Tomson; John R Cockcroft; Badri Shrestha; Ian B Wilkinson; Laurie A Tomlinson; Charles J Ferro; Jonathan N Townend Journal: Clin J Am Soc Nephrol Date: 2020-08-25 Impact factor: 8.237
Authors: William E Moody; Laurie A Tomlinson; Charles J Ferro; Richard P Steeds; Patrick B Mark; Daniel Zehnder; Charles R Tomson; John R Cockcroft; Ian B Wilkinson; Jonathan N Townend Journal: Am Heart J Date: 2013-11-06 Impact factor: 4.749