Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Biochemical basis of immunological and retroviral responses to DNA-targeted cytosine deamination by activation-induced cytidine deaminase and APOBEC3G.

Literature DB >> 19684020

Biochemical basis of immunological and retroviral responses to DNA-targeted cytosine deamination by activation-induced cytidine deaminase and APOBEC3G.

Linda Chelico¹, Phuong Pham, John Petruska, Myron F Goodman.

Abstract

Activation-induced cytidine deaminase (AID) and APOBEC3G catalyze deamination of cytosine to uracil on single-stranded DNA, thereby setting in motion a regulated hypermutagenic process essential for human well-being. However, if regulation fails, havoc ensues. AID plays a central role in the synthesis of high affinity antibodies, and APOBEC3G inactivates human immunodeficiency virus-1. This minireview highlights biochemical and structural properties of AID and APOBEC3G, showing how studies using the purified enzymes provide valuable insight into the considerably more complex biology governing antibody generation and human immunodeficiency virus inactivation.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19684020 PMCID： PMC2788826 DOI： 10.1074/jbc.R109.052449

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

50 in total

1. APOBEC3G DNA deaminase acts processively 3' --> 5' on single-stranded DNA.

Authors: Linda Chelico; Phuong Pham; Peter Calabrese; Myron F Goodman
Journal: Nat Struct Mol Biol Date: 2006-04-23 Impact factor: 15.369

Review 2. The current structural and functional understanding of APOBEC deaminases.

Authors: Ronda Bransteitter; Courtney Prochnow; Xiaojiang S Chen
Journal: Cell Mol Life Sci Date: 2009-06-23 Impact factor: 9.261

3. A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase.

Authors: Rahul M Kohli; Shaun R Abrams; Kiran S Gajula; Robert W Maul; Patricia J Gearhart; James T Stivers
Journal: J Biol Chem Date: 2009-06-26 Impact factor: 5.157

4. Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming.

Authors: Hugh D Morgan; Wendy Dean; Heather A Coker; Wolf Reik; Svend K Petersen-Mahrt
Journal: J Biol Chem Date: 2004-09-24 Impact factor: 5.157

5. Two levels of protection for the B cell genome during somatic hypermutation.

Authors: Man Liu; Jamie L Duke; Daniel J Richter; Carola G Vinuesa; Christopher C Goodnow; Steven H Kleinstein; David G Schatz
Journal: Nature Date: 2008-02-14 Impact factor: 49.962

6. Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.

Authors: Phuong Pham; Marcus B Smolka; Peter Calabrese; Alice Landolph; Ke Zhang; Huilin Zhou; Myron F Goodman
Journal: J Biol Chem Date: 2008-04-16 Impact factor: 5.157

7. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).

Authors: P Revy; T Muto; Y Levy; F Geissmann; A Plebani; O Sanal; N Catalan; M Forveille; R Dufourcq-Labelouse; A Gennery; I Tezcan; F Ersoy; H Kayserili; A G Ugazio; N Brousse; M Muramatsu; L D Notarangelo; K Kinoshita; T Honjo; A Fischer; A Durandy
Journal: Cell Date: 2000-09-01 Impact factor: 41.582

8. A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.

Authors: Artem Blagodatski; Vera Batrak; Sabine Schmidl; Ulrike Schoetz; Randolph B Caldwell; Hiroshi Arakawa; Jean-Marie Buerstedde
Journal: PLoS Genet Date: 2009-01-09 Impact factor: 5.917

9. The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription.

Authors: Hong Ming Shen; Michael G Poirier; Michael J Allen; Justin North; Ratnesh Lal; Jonathan Widom; Ursula Storb
Journal: J Exp Med Date: 2009-04-20 Impact factor: 14.307

10. RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1.

Authors: Hendrik Huthoff; Flavia Autore; Sarah Gallois-Montbrun; Franca Fraternali; Michael H Malim
Journal: PLoS Pathog Date: 2009-03-06 Impact factor: 6.823

11 in total

1. Single-stranded DNA scanning and deamination by APOBEC3G cytidine deaminase at single molecule resolution.

Authors: Gayan Senavirathne; Malgorzata Jaszczur; Paul A Auerbach; Thomas G Upton; Linda Chelico; Myron F Goodman; David Rueda
Journal: J Biol Chem Date: 2012-02-23 Impact factor: 5.157

2. Grand challenge commentary: The chemistry of a dynamic genome.

Authors: Rahul M Kohli
Journal: Nat Chem Biol Date: 2010-12 Impact factor: 15.040

3. Targets of somatic hypermutation within immunoglobulin light chain genes in zebrafish.

Authors: Alexis E Marianes; Anastasia M Zimmerman
Journal: Immunology Date: 2010-11-11 Impact factor: 7.397

4. Analysis of a single-stranded DNA-scanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversity.

Authors: Phuong Pham; Peter Calabrese; Soo Jung Park; Myron F Goodman
Journal: J Biol Chem Date: 2011-05-12 Impact factor: 5.157

5. A structural basis for the biochemical behavior of activation-induced deoxycytidine deaminase class-switch recombination-defective hyper-IgM-2 mutants.

Authors: Yunxiang Mu; Courtney Prochnow; Phuong Pham; Xiaojiang S Chen; Myron F Goodman
Journal: J Biol Chem Date: 2012-06-19 Impact factor: 5.157

6. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.

Authors: Uttiya Basu; Fei-Long Meng; Celia Keim; Veronika Grinstein; Evangelos Pefanis; Jennifer Eccleston; Tingting Zhang; Darienne Myers; Caitlyn R Wasserman; Duane R Wesemann; Kurt Januszyk; Richard I Gregory; Haiteng Deng; Christopher D Lima; Frederick W Alt
Journal: Cell Date: 2011-01-20 Impact factor: 41.582

7. Conserved Interaction of Lentiviral Vif Molecules with HIV-1 Gag and Differential Effects of Species-Specific Vif on Virus Production.

Authors: Wenwen Zheng; Limian Ling; Zhaolong Li; Hong Wang; Yajuan Rui; Wenying Gao; Shaohua Wang; Xing Su; Wei Wei; Xiao-Fang Yu
Journal: J Virol Date: 2017-03-13 Impact factor: 5.103